Phyiology Review Slides Lec. 20

Question 1

Compensatory response of Metabolic Alkalosis?

Answer 1

• Decrease VENTILATION

- Increased Renal Bicarbonate EXCRETION

Question 2

Metabolic Alkalosis

Answer 2

Caused by a Rise in the EC Fluid [Bicarbonate]

Question 3

PCO2 is mainly controlled by what?

Answer 3

Rate of RESPIRATION

Question 4

Bicarbonate [ ] is Controlled mainly by what?

Answer 4

The Kidneys

Question 5

Alkalosis

Answer 5

Occurs when there is an INCREASE in the Ratio of BICARBONATE to H+

• Excess will be EXCRETED in Urine
• Effect is to add H+ to EC

Question 6

What is the MOST Important EC Buffer System?

Answer 6

BICARBONATE Buffer System

Question 7

What causes Respiratory Alkalosis?

Answer 7

HYPER-ventilation

Question 8

Importance of the buffer system in the Kidney Tubule

Answer 8

• Becomes [ ] in the tubules

- Lower pH in tubular fluid brings the operating range of the buffer system closer to pK of the system

Question 9

Compensatory response of Respiratory Alkalosis?

Answer 9

Reduction in plasma Bicarbonate by Renal EXCRETION

Question 10

Carbonic Anhydrase

Answer 10

Enzyme necessary for the formation of CARBONIC ACID from CO2 and Water

Question 11

Respiratory Alkalosis

Answer 11

There is a DECREASE of [CO2]

Question 12

Bicarbonate Ion Reabsorption process

Answer 12

• Filtered bicarbonate must react with SECRETED H+
• Forms Carbonic Acid (H2CO3)
• Dissociates to CO2 + Water
• Diffuses in Tubular cells
• Form Carbonic acid, which then dissociates to Bicarbonate
• Bicarbonate diffuses into the BLOOD

Question 13

Phosphate Buffer System

Answer 13

Plays a role in Buffering RENAL Tubular Fluid

Question 14

Lower limit of pH that can be achieved in normal Kidneys

Answer 14

4.5