Physiology Review Slides Lec. 19 Flashcards
Calcium is ____ and _____ but it is NOT ______.
- Filtered and Reabsorbed
- Secreted
Addison’s Disease
DEFICIENCY in Aldosterone Secretion
What Stimulates K+ uptake by cells?
3 Things
- Insulin
- Aldosterone
- Catecholamine
(Epinephrine)
“CIA”
Increase Sodium has what effect on Potassium secretions?
- No Net effect
- Aldosterone LOWERS K+ secretions
- INCREASES GFR and Decreasing Proximal Tubule reabsorption leads to an INCREASE in Flow rate
Metabolic Alkalosis effects on K+ concentration?
Leads to a DECREASE in EC [K+]
Where are Principal Cells found?
In the LATE Distal Tubule and CORTICAL CD
Metabolic Acidosis effects on K+ concentration?
Leads to an INCREASE in EC [K+]
Factors that can cause Hyperkalemia?
- Cell Lysis
- Increased EC Fluid Osmolarity
- Strenuous Exercise
“CIS”
Increase Sodium has what effect on Aldosterone secretions?
Increase in Na+ LOWERS Aldosterone secretion
How does metabolic acidosis lead to and Increase in EC [K+]?
- The increase of H+ leads to a decrease in Activity for the Na/K ATPase pump.
Reabsorption of Calcium
- Occurs mainly in the PROXIMAL tubule
- 99% of filtered Ca++ is reabsorbed
- 65% is reabsorbed in the PT by the PARACELLULAR route
- 20% reabsorbed in the PT by the TRANSCELLULAR route
Hyperkalemia
- Deficiency in Aldosterone secretion
- Too Much K+ in the blood
- Addison’s Disease
PTH
- Stimulates bone RESORPTION
- Stimulates activation of Vitamin D
- Indirectly Increases Tubular Ca++ reabsorption
Where is Aldosterone produced?
In the Adrenal cortex
Fxn of Principal cells?
- Secrete POTASSIUM
- Control of K+ secretion
- Uses Na+/K+ Pump
(Sodium is Reabsorbed)
