Physiology Flashcards
Intercalated discs contain what 2 things + function?
Desmosomes (tension) and gap junctions (electrical spread of signal)
AVN has …. cells, is …. conducting and is the only point …..?
Smaller, slow and of electrical activity between atria and ventricles
What does sympathetic vs parasympathetic innervation do to HR and AVN delay?
Speeds up and decreases vs slows down and increases
What dominates the HR under resting conditions?
Vagal tone
What area of the heart does the vagus nerve not supply that the sympathetic does?
Myocardium
Which neurotransmitter acts on which receptor in parasympathetic vs sympathetic control of the heart?
ACh on M2 receptors vs NA on beta 1 receptor
Name a competitive inhibitor (muscarinic antagonist) of ACh that is used in bradycardia?
Atropine
Effect of sympathetic and parasympathetic innervation on the pacemaker potential slope?
Parsympathetic decreases and sympathetic increases
Which blood vessel supplies the SAN?
Right coronary artery
What creates the striated appearance of cardiac muscle?
Myofibrils of actin and myosin in sarcomeres
Shape and colour of actin + myosin filaments?
Actin (thin and pale) + myosin (thick and dark)
Which way does actin and myosin slide?
Actin slides over myosin
What 2 things is required to allow cross bridge formation?
ATP
Calcium
What is the role of calcium in sliding of filaments?
Forms cross bridge by binding to troponin and shifting tropomyosin out of the actin cleft
What is meant by the refractory period?
Period following action potential where it is not possible to generate another action potential
What are the 2 phases where a new action potential cannot be generated?
Phase 2 and 3
What is the clinical benefit of the refractory period?
Prevents tetanic contractions of the heart
Define stroke volume + normal value + how to calculate?
Volume of blood ejected by each ventricle per heart beat + 70 ml + EDV-ESV
EDV/pre-load is determined by ….. which is determined by which 3 things?
Venous return + skeletal, respiratory pump and venoconstriction
Describe the Frank-Starling Law of the Heart + sympathetic effect?
Greater EDV the greater the SV + shift curve left
Other effect of stretching the heart fibers to increase SV?
Stretch increases affinity of troponin C for Ca
ESV/afterload is determined by?
The resistance against which the heart has to pump into
How does the Frank-Starling law compensate partially for decreased stroke volume?
EDV increases (due to failure to pump full SV) so force of contraction increases
What does chronotropic mean + can this be affected by sympathetic or parasympathetic innervation?
Speed of the heart + both
What does ionotropic mean + can this be affected by sympathetic or parasympathetic innervation?
Force of contraction + only sympathetic (para does not supply myocardium)
What is meant by cardiac output + how to calculate?
Volume of blood pumped out by each ventricle per minute + SV x HR
How much blood fills the ventricles in passive filling?
80%
Pressure in the atria and ventricles + aorta is normally?
Close to zero + 80 mm Hg
Duration of diastole and systole?
0.5 seconds and 0.3 seconds
Are the ventricles filled in isovolumetic contraction and relaxation + explain the state of the ventricles?
Filled in contraction and empty in relaxation + in a closed box (all valves shut)
What produces the dicrotic notch in the aortic pressure curve?
Aortic valve closing
Cause of S1, S2, S3 and S4?
Systole, diastole, pathologic in younger people but CHF in older, stiff ventricles e.g. LVH
Splitting of S2 is heard on … and is caused by + why?
Inspiration and pulmonary valve closing later than aortic + intrapulmonary pressure decreases so venous return increases
Cp needs to be around …. to stop blood flow and below …. to allow blood flow?
120 and 80 mm Hg