Physiology

Question 1

What are the steps at neuromuscular junction

Answer 1

1 Ap arrival
2 voltage gated ca channel activatation
3 exocytosis of ach
4 ach released into synaptic cleft
5 ach opens post synaptic ach receptors in sarcolemma
6 depolarization Na inflow K outflow
7 Ach inactivation (enzymatically by acherase)

Question 2

AchR antagonist?

Answer 2

D- tuborcaine( temporary)

Bangarotoxin( permemnat)

Question 3

Synaptic toxin?? And its effect?

Answer 3

Botulinum from clostridium

Prevents prevents presynaptic docking proteins

Question 4

Why do muscle develop fatigue?

Answer 4

Depletion of tap and glycogen

Depletion of transmitter

Question 5

Why slow muscles are resistant to muscle fatigue?

Answer 5

Use fat for energy!

Question 6

What kind of contraction used I’d holding an object?

Answer 6

Isometric

Question 7

What contraction used in walking?

Answer 7

Isotonic !!

Question 8

Contraction for posture?

Answer 8

Isometric

Question 9

Load lifting contraction?

Answer 9

Isotonic !