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Msk > Microbiology > Flashcards

Microbiology Flashcards

1
Q

Other genetic cause of SLE?

A

Genetic complement deficiency in 50% of SLE

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2
Q

What uv light can cause to SLE ?

A

Induce apoptosis of keratinocytes

2- expression of auto nuclear antigens (e.g. Ro & La)

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3
Q

What microbes can cause SLE?

A

Retrovirus

EBV

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4
Q

How microbes can cause SLE?

A
  1. Molecular mimicry
  2. Polyclonal activation
  3. Cytokines production
  4. Release of sequesterd Ag
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5
Q

Relation to cytokines production?

A 
Those with active disease have higher tighter of IFN-gamma
= increase expression of class II Mhc
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6
Q

Molecular mimicry in SLE?

A

Cross reactivity of Ro and Sm with viral Ag

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7
Q

What happens in polyclonal activation?

A

IgM (anti nuclear)

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8
Q

How drug induced SLE occur?

A

By forming conjugated with self antigen resulting in altered structures causing auto reactivity

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9
Q

Immunological abnormalities seen in SLE?

A
  1. Decrease number and function of CD-8 T and Nk cells
  2. Decrease T suppressor TgF-beta
  3. Dysregulated cytokines
    • high IL- 3,4,5,6,10 + IFN gamma
    • low IL-2
  4. Autoantibodies to complement ( C1 q)
  5. Defective immune complex clearance
  6. Polyclonal B cell activation
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10
Q

Other antibodies seen in SLE ?

A

RF
C1 q
HSP

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11
Q

What genes mostly predispose to SLE?

A

HLA-DR2/3

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12
Q

Etiological agents in septic

A 
S. Aeurs 
Strepto agalectica in diabetics
Other strepto
Aneaerobes
H. Influenza in 3m to 2yrs
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13
Q

Characteristic of h influenza

A

Pleomotphic bacillli

Factors needing like hemin and bad

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14
Q

Most infective arthris are by hemtegonous route why?

A

Highly vascular synovial membrane

With no limiting basement plate like

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15
Q

Patho physiology of s.aures infection?

A

Release proteoglycans from cartilage leading to its degradation

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16
Q

Predilection to axial skeleton is seen in iv drug users by?

A

Gnb and pseudomonas

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17
Q

Disseminated gonococcal infection is seen in

A

Inherited complement deficiencies

18
Q

Which cultural is more positive in gonococcal infection?

A

Blood better than synovial!

Even better is geniturinary

19
Q

Characteristics of salmonella

A

Gram negative non lactose fermenting bacilli
Present with salmonella
Synovial fliudvia sterile!!

20
Q

Bacteria after no pasteurized milk causing sarcoillitis with negative synovial fluid?

A

Bruxelles

21
Q

Hiv patient with low grade inflammation of a single joint?

A

Mycobacterium or fungal !

22
Q

RF for infective arthritis ?

A 
Bacterima
Phagocytic defect
Liver disease
Chronic steroid use
Prexesting connective tissue disorder
Hemophilia
Recurrent hemarthrosis
I. Drugs
23
Q

One of the commonest symptoms of influenza is

A

Myalgia

24
Q

Immunity to influenza is

A

Type specific

25
Q

Recurrent influenza is by

A

Antigentically different strains

26
Q

Fever, rash and joint pain think of

A

Ortho borne viruse

27
Q

Jaundice and severe paint of muscle and joint with malaise indicates

A

Hep B

28
Q

How parvovirus presents

A

Rash (slapped check) and athralgia = erythema infectiosim or fifth disease

29
Q

Erythema infectiosim by

A

Immune complex deposition

30
Q

Characteristic of osteomyelitis

A

Bone infection causing progressive bone destruction and formation is sequestra

31
Q

Chronic osteomyelitis

A

Bone necrosis and vascular damage

Presence of foreign materials predisposing to nidus formation

32
Q

In traumatic osteomyelitis think of

A

S auerus and Gnb!

33
Q

C perefregis can also cause

A

Osteomyelitis

34
Q

In diabetic foot think of

A

Bones of foot osteomyelitis

35
Q

In severe otits external think of osteomyelitis affecting the

A

Skull!!

36
Q

Important osteomyelitis causative agents are ?

A

Anaerobes
Bacteroids
Mycobacterium

37
Q

What causes osteomyelitis in IV drug users

A

Pseudomonas in spine or pelvis

38
Q

Spine involved in osteomyelitis usually seen in

A

Adults

39
Q

Severe otitis externa then fever and tenderness in skull ?

A

Chronic osteomyelitis

40
Q

Features is chronic osteomyelitis

A 
Sinuses
Swelling 
Deformity
Defective healing
Loosening of prosthesis
41
Q

Pus from infected bone can show

A

AFB and s. Auerus

Msk (10 decks)

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