Phys 2 Pulmonary Blood Flow Flashcards
extra-alveolar capillaries?
O2/CO2 profile?
blood from where?
return to heart where?
what does that cause?
Blood pressure and pulmonary blood pressure
what is the equation?
difference between values for blood pressure and pulmonary pressure?
Pulmonary vascular resistance
Determined by?
PVR during exercise?
PVR and lung volume?
Why pass out while standing a long time?
how will not locking knees help?
- Here gravity works on the blood in our bodies. with gravity blood pressure in our legs is increased compared to that of the heart or brain
- same can happen in the lungs
Regional blood flow in the lungs
Apex of the lung
Regional blood flow in the lungs
middle region of the lung
Regional blood flow in the lungs
Base of the lung
Chemical modulators of pulmonary blood flow?
Why do we want to keep alveoli “dry”?
- alveoli allow oxygen to move from air to blood. Oxygen is not terribly water soluble.
- If capillaries leaked water into alveoli it would impair ability of oxygen to cross blood
What controls how much fluid moves from capillary to the lung?
Starling forces
What are the two general pressures at work with starling forces?
- Hydrostatic pressure
- Oncotic pressure
Hydrostatic pressure?
where are these
(fluid pushing against the tissue or walls of the capillary)
- The capillary (Pc)
- blood pressure in capillary trying to push fluid into alveoli
- The tissue (Pt)
- in rest of body this pushes fluid into capillary
hydrostatic pressure in the lungs
what happens to Ptissue in the lungs?
what causes this?
Oncotic pressure
where?
(think osmotic pressure of the fluids involved)
- The plasma (capillary oncotic pressure) πc
- tries to pull water into the capillary
- The tissue (tissue oncotic pressure) πTissue
- tries to pull water into the alveolus
Forces moving water from capillary to alveolus?
Forces moving water from alveolus to capillary?
Starling forces equation for the lung?
what is the biggest force?
Pc (hydrostatic pressure in the capillary)is the largest single force
Net result of adding up starling forces is favor net filtration where?
this good or bad?
favors net filtration of fluid into the alveoli
(this is bad)
With a net force into alveoli
fluid is bad for gas exchange so what do we do?
Lymphatics
Metabolic functions of the lung
(Blood pressure)
start with what?
end product?
intermediates?
where are things produced?
Angiotensin can raise blood pressure through aldosterone
What can ACE inhibitors do?
what does ACE stand for?
Metabolic functions of the lung
Lead to production of what?
whats removed
