Phenotypes of T helper cells

Question 1

Th1 —> signature cytokine, immune action, hose defense, roles in disease, transcription factor

Answer 1

IFN-gamma 
mac activation, IgG production
intracellular microbes 
autoimmune disease
tissue damage associated with chronic infections

T-BET

Question 2

Th2 —> signature cytokine, immune action, hose defense, roles in disease, transcription factor

Answer 2

IL-4, IL-5, IL-13

mast cell, eosinophil activation, IgE production, alternative macrophage activation

helminthic parasites

allergic diseases

GATA-3

Question 3

Th17 —> signature cytokine, immune action, hose defense, roles in disease, transcription factor

Answer 3

IL-17A, IL17F, IL-22

neutrophilic, monocytic inflammation

extracellular bacteria, fungi

autoimmune and inflammatory disease

RORyT