Antibody Mediated Response II Flashcards
Plasma cell travel itinerary
travels from LN to spleen or back to bone marrow
life span of plasma cell
around 5 days
how much Ab is produced?
enough to keep up with invaders
What interaction is CRITICAL for production of memory cells?
CD40L–CD40
How good is immunological memory produced without T cell help?
not at all
TD vs TI antibody features
TD = all isotypes and isotype switching possible TI = LITTLE OR NO, may be SOME IgG from IgM
TD = possesses affinity maturation TI = Little or no affinity maturation
TD = Secondary response TI = Only some antigens
TI Ags: Properties
1) Polymeric structure
2) resistance to degradation, stimulates system for a long time
3) polyclonal activation of B cells
TI Ag properties which MHC complex?
MHC II cant bind non-peptides
TI-2 Ag how they effect
through cross linking many BCRs
TI-1 Ags
polycloncal activators of B cells
TI-2 Ags
(non polyclonal)
there are Ags with repeating epitopes for cross linking BCRs
B cell activation via TI-1 Ags
1st signal: Ag stimulation of BCR
2nd signal: Ag stimulation of TLRs
note: mitogen on TI-1 does not have to be specific, can bind non-specifically
NO CD4 help of course
B cell activation via TI-2 Ags
First signal: Ag stimulation of the BCR
Second signal: cross linking/clustering of BCRs
TI-2 Ags are generated against what kind of Ags?
repetitive Ags
TI-2 ags produce
no memory
