Hypersensitivity

Question 1

hemolysis, anemia

Answer 1

Type II

Erythrocyte membrane proteins = Ag

Question 2

Bleeding

Answer 2

Type II

platelet membrane proteins = Ag

Question 3

nephritis, lung hemorrhage

Answer 3

Type II

Goodpasture’s syndrome

non-collagenous protein in basement membranes = Ag

Question 4

hyperthyroidism

Answer 4

Type II

Thyroid stimulating hormone cells = Ag

Grave’s disease

Question 5

muscle weakness/paralysis

Answer 5

Type II

acetylcholine using receptors

Myasthenia gravis

Question 6

skin vesicles (bullae)

Answer 6

Type II

proteins in intracellular junctions of epidermal cells (cadherins) = Ag

Pemphigus vulgaris

Question 7

Myocarditis, arthritis

Answer 7

Type II

Rheumatic fever

Streptococcal cell wall-Ab complex reacts with myocardial antigen

Question 8

nephritis, arthritis, vasculitis

Answer 8

Type III

systemic lupus erythematosus

DNA, nucleoproteins, others

Question 9

vasculitis

Answer 9

Type III

Polyarteritis nodos

microbial Ags

Question 10

nephritis

Answer 10

Type III

post-streptococcal glomerulonephoritis

Question 11

systemic vasculitis, nephritis, arthritis

Answer 11

Type III

serum sickness

Question 12

cutaneous vasculitis

Answer 12

Type III

arthus reaction

Question 13

What is seen in all Type III disorders?

Answer 13

injury is caused by complement mediated Fc receptor mediated inflammation, but the major mechanism of damage is classical activation of complement

Question 14

Type IV hypersensitivity: major causes

Answer 14

autoimmunity, exaggerated/persistent response to environmental Ags

Question 15

what cell mediates Type IV hypersensitivity?

Answer 15

T cells

Question 16

what cell mechanism mediates type II hypersensitivity?

Answer 16

Ab mediated disease

Question 17

what cell mechansism mediates type III hypersensitivity?

Answer 17

immune-complex disease

Question 18

type IV sensitivity is caused by recruitment of what cells?

Answer 18

Th1

Question 19

T IV HS is also called

Answer 19

Delayed Type Hypersensitivity

Question 20

macrophage dependent tissue damage

Answer 20

T IV HS

brought on by Th1 memory

Question 21

What HS rxns can be transferred, and what do they contain?

Answer 21

Type I, II, III can be transferred by serum containing Abs.

Type IV requires transfer of antigen specific Th1 clones that orchestrate MO response

Question 22

Demyelination of the central nervous system, snensory motor dysfunction

Answer 22

T IV HS

Multiple sclerosis

myelin proteins = Ag

Question 23

Inflammation of synovium, erosion of cartilage and bone joints

Answer 23

Rheumatoid arthritis

T IV HS

unknown antigens

Question 24

Impaired glucose metabolism

Answer 24

T IV HS

Type I diabetes mellitus

Question 25

inflammation of bowel wall, abdominal pain, diarrhea hemorrhage

Answer 25

T IV HS

Crohn’s disease

Question 26

DTH reaction in skin

Answer 26

contact sensitivity

T IV HS

Question 27

Chronic inflammation

Answer 27

chronic infections

T IV HS

Question 28

DTH results from

Answer 28

activation of T cells, particularly CD4 cells

typically develops 24/48s hrs after Ag challenge

Question 29

PPD

Answer 29

purified protein derivative of mycobacterium tuberculosis

elicits DTH rxn called tuberculin rxn

Question 30

what 3 ways can humans be sensitized to DTH rxns?

Answer 30

microbial infection, contact sensitization, immunization

Question 31

how many days do we expect primary DTH contact to produce outward symptoms?

Answer 31

none. takes 7-10 days, then requires re-exposure