Mechanisms of Host Defense continued

Question 1

Membrane attack: component, groups of pathogens

Answer 1

defensins, complement

G-

Question 2

Opsonophagocytosis: component, groups of pathogens

Answer 2

neutrophils, MOs, CR1 (C3b), FcER

extracellular bacteria/yeasts

Question 3

Intracellular killingcomponent, groups of pathogens

Answer 3

phagolysosomes : ROS, nitric acid

Extracellular bacteria, yeasts

Question 4

Toxin neutralization: component, groups of pathogens

Answer 4

IgM, IgG, IgA, immune complexes

exotoxin producing microbes

Question 5

virus neutralization

Answer 5

IgM, IgG, IgA, phagocytic cells, mucus

respiratory and GI viruses

Question 6

Extracellular killing: component, groups of pathogens

Answer 6

neutrophils/mac

filamentous fungi, parasites

Question 7

MO mediated intracellular killing: component, groups of pathogens

Answer 7

Th1 cells, NK cells, IFN-gamma, nitric acid

obligate or facultative intracellular pathogens

Question 8

cytotoxic T killing: component, groups of pathogens

Answer 8

CD8s, MHC class I, CD4s, IL-2

viruses and many intracellular bacteria and fungi

Question 9

Eosinophil mediated cytotoxicity

Answer 9

Eosinophils, IgE, FcER

intestinal parasites (helminths)

Question 10

Inhibitors of intracellular replication

Answer 10

Type I interferons

most viruses

Question 11

NK cell mediated cytotoxicity

Answer 11

NK cells MHC class I