Phenelzine Flashcards
What is phenelzine?
Monoamine oxidase inhibitor. Phenelzine is an antidepressant
mechanism of action
not fully determined, but it is believed to irreversibly inhibit monoamine oxidase (MAO).
two forms of MAO
MAO, (A+B)
where is MAO A found
in cells in the periphery
where is MAO B found
found extracellularly and predominately in the brain
true or false, the two subtypes are different substrates
true
what does MAO A catalyse?
the breakdown of serotonin, norepinephrine, epinephrine, dopamine and tyramine
what does MAO B catalyse?
acts on phenylethylamine, norepinephrine, epinephrine, dopamine and tyramine
why does the concentration of free amines esp serotonin and NA increase?
As Phenelzine inhibits MAO
why is MAO A inhibition is thought to be more relevant to antidepressant activity
as selective MAO B inhibitors (selegiline), have no antidepressant effects.
true or false Phenelzine is the first choice ant-depressant therapy available.
false
how long for the full clinical benefits to be realised?
several weeks of therapy may be required
