Diazepam Flashcards
what is Diazepam
A Benzodiazepine
which agents do Benzodiazepines have the same active metabolite as?
chlordiazepoxide and clorazepate
what does Benzodiazepine bind nonspecifically to?
to benzodiazepine receptors (BR)
what do the benzodiazepine receptors (BR) mediate
These receptors mediate sleep, affects muscle relaxation, anticonvulsant activity, motor coordination, and memory
what are the BRs thought to be linked to
GABA-A receptors
What is activation of BRs thought to do?
activation of the BRs lead to increasing the affinity of GABA for its receptor, enhancing its effects
what does binding of GABA to its receptor do?
opens the chloride channel, causing hyperpolarization and preventing further cell excitation.
what is diazepam used for
selectively for anxiety and as a muscle relaxant
