Clozapine Flashcards
1
Q
what is clozapine
A
A psychotropic agent .selective monoaminergic antagonist with high affinity for 5HT2, and D2 receptors
2
Q
what is clozapine used to treat?
A
treatment of schizophrenia
3
Q
what does D2 antagonism relieve
A
positive symptoms
4
Q
what does 5-HT2A antagonism relieve
A
negative symptoms
5
Q
what is clozapine also shown to bind to and what might this explain?
A
1 and 2 adrenergic, muscarinic M1-5 receptors and H1 histaminergic receptors, which may explain its therapeutic and side effect profile
