Buspirone

Question 1

What is Buspirone?

Answer 1

5HT partial receptor agonist

Question 2

What is Buspirone used to treat?

Answer 2

treat generalized anxiety

Question 3

benefits of Buspirone?

Answer 3

does not cause sedation (drowsiness) tolerance or physical dependence. In addition it does not cause anticonvulsant or muscle relaxant effects.

Question 4

mechanism of Buspirone action

Answer 4

that it has high affinity for 5-HT1A receptors. These are present on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus.

Question 5

effect of Buspirone?

Answer 5

to inhibit the firing rate of 5-HT-containing neurons in the dorsal raphe

Question 6

which receptor does Buspirone also bind to?

Answer 6

binds D2 receptors

Question 7

what is the effect of Buspirone binding to D2 receptors?

Answer 7

blocking presynaptic dopamine receptors.

Question 8

what is the net result of buspirone actions

Answer 8

serotonergic activity is suppressed while noradrenergic and dopaminergic cell firing is enhanced.