Oxybutynin Flashcards
1
Q
what is oxybutynin?
A
A muscarinic acetylcholine receptor antagonist.
2
Q
what is oxybutynin used to treat
A
to relieve urinary and bladder difficulties
3
Q
what does oxybutynin competitively antagonize and what are the effects
A
the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor and so reduce detrusor activity
4
Q
which isomer does most if the antimuscarinic activty of oxybutymin occur
A
R isomer
5
Q
what two isomers is oxybutynin made of?
A
R and S
6
Q
what extensively metabolizes oxybutynin?
A
by the cytochrome P450 enzyme systems, particularly CYP3A4, found mostly in the liver and gut wall
7
Q
how much of the adminstered dose of oxybutynin is excreted unchanged in the urine?
A
less than 0.1%
