PHCT - Module 1 Flashcards
Maimonides
Moses ben Maimon
a treatise on the treatment of poisonings from insects, snakes, and mad dogs
Poisons and Antidotes (1198)
a treatise on the treatment of poisonings from insects, snakes, and mad dogs
Poisons and Antidotes (1198)
Chinese Arrow Poison
Aconite
Wrote on the subject of bioavailability, noting that milk, butter, and cream could delay intestinal absorption.
Maimonides
Poison/Antidote
Opium
Paracelsus full name
Philippus Aureolus Theophrastus Bombastus von Hohenheim
the dose makes the poison.
Toxicon
Considered to be the modern father of toxicology
Mathieu Orfila
1 of the poisons in use “is arsenic”
Contribution: Treate de poisons
1st attempt at a systematic correlation between chemical and biological information of known poison.
Autopsy
Mathieu Orfila
forced to drink Hemlock
Socrates
took poison hidden in his pen for suicide
Demosthenes
Use of Muscarine and Nicotine
Lithium - Eskalith
biomedical
Half-life of lead
2 months
The project focused on identifying and analyzing alternative transportation measures for Metro Manila that would reduce greenhouse gas (GHG) emissions and improve air quality and public health.
Integrated Environmental Strategies(IES)
Three Main Professional Activities:
Descriptive, Mechanistic, Regulatory Toxicology
Hybrid of analytic chemistry and fundamental toxicological principles
It is concerned with the medico-legal aspects of the harmful effects of chemicals on humans.
Forensic Toxicology
Deals within the realm of medical science concerned with disease caused by, or uniquely associated with toxic substances.
Clinical toxicologists develop antidotes and treatment regimens for ameliorating poisoning and xenobiotic injury.
Clinical Toxicology
focuses on the impacts of chemical pollutants found in the environment on biological organisms.
Studies chemicals that are contaminants of food, water, soil, or the air.
Environmental Toxicology
Deals with the chemicals found in the workplace.
The major emphasis of occupational toxicology is to identify the agents of concern, define the conditions leading to their safe use, and prevent the absorption of harmful amounts.
Occupational Toxicology
an abnormal, undesirable, or harmful effect on the well-being that is indicated by some measurable endpoints such as mortality, food consumption, body and organ weights, enzyme levels or pathologic findings.
Adverse Effects
chromosomal breakage resulting in rearrangement of pieces of chromosomes
The loss, addition, or rearrangement of chromosomes
Can be associated with various chronic inflammatory disorders
Clastogenesis
chemicals with molecular weights of less than 1000 and generally react with endogenous carrier molecules to become antigens before they exhibit immunogenicity
Haptens
process by which the genetic information of an organism is changed, resulting in a mutation and subsequent transmission during cell division Heritable changes in genetic material that are limited to the effects on the nucleic acid.
Mutagenesis
