PHCP - ENDOCRINE

Question 1

responsible for normalized growth

Answer 1

Thyroid

Question 2

Main component of Thyroid

Answer 2

Iodine

Question 3

responsible for bone regulation - calcium

Answer 3

Calcitonin

Question 4

Ratio of T4:T3

Answer 4

13:1

Question 5

is an effective means of rejecting the large quantities of iodide and therefore preventing the thyroid from synthesizing large quantities of thyroid hormones.

Answer 5

Wolff-Chaikoff effect

Question 6

Thioamides example

Answer 6

PTU, methimazole

Question 7

MIT + DIT =

Answer 7

T3

Question 8

DIT + DIT

Answer 8

T4

Question 9

process where T4 is converted to T3

Answer 9

DEIONIZATION

Question 10

Enzyme involved in DEIONIZATION

Answer 10

5’ deiodinase

Question 11

Oncogene fam Includes

Answer 11

steroid hormones receptor

Question 12

T_ resp for metabolism

Answer 12

T3

Question 13

Disease associated with Hyperthyroidism

Answer 13

Grave’s disease

Question 14

Disease associated with Hypothyroidism

Answer 14

Hashimoto Disease

Question 15

Hypothyroidism
Adult Disease

Answer 15

Mixed edema

Question 16

Hypothyroidism
Infant Disease

Answer 16

Cretinism

Question 17

Used for Thyrotoxicosis

Answer 17

Propylthiouracil (PTU)
Methimazole

Question 18

Methimazole is __x more potent than Propylthiouracil

Answer 18

10x

Question 19

DOC for Thyrotoxicosis in Adult and Children

Answer 19

Methimazole

Question 20

ADR of Methimazole

Answer 20

cholestatic jaundice

Question 21

PTU black box warning:

Answer 21

severe hepatitis

Question 22

Fetal ADR for thionamides

Answer 22

agranulocytosis

Question 23

INH of organification and hormone release * used in surgical thyrodectony

Answer 23

Iodide

Question 24

Adrenergeric Blockers - w/o _________

Answer 24

(ESA)
EXTRINSIC SYMPATHOMIMETIC ACTIVITY

Question 25

release beta-rays

Answer 25

RAI

Question 26

Liothyronine HALF LIFE

Answer 26

24h t1/2

Question 27

Hypersensitivity Type 1

Answer 27

Allergic Reaction / Immediate Hypersensitivity

Question 28

Hypersensitivity Type 2

Answer 28

CYTOTOXIC RXN

Question 29

Hypersensitivity Type 3

Answer 29

IMMUNE COMPLEX RXN

Question 30

Hypersensitivity Type 4

Answer 30

DELAYED HYPERSENSITIVITY

Question 31

IGE, mast cell, basophil; within 1hr

Answer 31

Type 1

Question 32

Examples: bee sting, latex allergy, medications (penicillin), urticaria, anaphylaxis, atopy (allergic rhinitis, asthma, atopic dermatitis or eczema)

Answer 32

Type 1

Question 33

IgB, IgM; Hours to Days

Answer 33

Type 2

Question 34

Igb, IgM; 1-3 weeks

Answer 34

Type 3

Question 35

Examples: Hemolytic rxn w/meds, graft rejections

Answer 35

Type 2

Question 36

Examples: SLE, serum sickness

Answer 36

Type 3

Question 37

Examples: Mantoux test (PDD) (10-15MM) AKA MENDEL MANTOUX TEST -Nickel Allergy, SJS, Poison Ivy (Uroshiol)

Answer 37

Type 4

Question 38

serves as scaffold for thyroid hormone synthesis

Answer 38

Thyroglobulin

Question 39

- formation of MIT (monoiodotyrosine) and DIT (diiodotyrosine)

Answer 39

Iodine organification

Question 40

of thyroglobulin liberates the T3 and T4 in the blood

Answer 40

Proteolysis

Question 41

Most thyroid hormone is transported by ______ . Prealbumin and albumin also serves as carriers.

Answer 41

THYROXINEBINDING GLOBULIN (TBG)

Question 42

Heat intolerant Pale edema, exopthalmos Palpitation, tachycardia

Answer 42

Hyperthyroidism

Question 43

Difficulty in breathing Inc appetite, loss weight, diarrhea Tremor, Nervousness, menstrual irregularity Extreme muscle weakness

Answer 43

Hyperthyroidism

Question 44

Polyuria Anemia Dysmenorrhea, amenorrhea Inc basal metabolic rate, hyperglycemia

Answer 44

Hyperthyroidism

Question 45

Cold intolerant Drooping eyelid Bradycardia Hypoventilation and CO2 retention

Answer 45

Hypothyroidism

Question 46

Dec appetite, weight gain, constipation Lethargy, stiffness, infertility Excessive muscle contraction

Answer 46

Hypothyroidism

Question 47

Urinary retention Anemia (most common) menorrhagia Dec basal metabolic rate, hyperlipidemia

Answer 47

Hypothyroidism

Question 48

It is the clinical syndrome that results when tissues are exposed to high levels of thyroid hormone

Answer 48

Hyperthyroidism

Question 49

– AKA thyrotoxic crisis

Answer 49

– Thyroid Storm

Question 50

– this test can see if your thyroid gland has any nodules.

Answer 50

* Thyroid ultrasound –

Question 51

– this test uses a radioactive substance to make an image of the thyroid.

Answer 51

Thyroid scan –

Question 52

measure the amount of thyroid hormone and thyroid stimulating hormone in your blood.

Answer 52

Blood tests –

Question 53

Block thyroid hormone synthesis by inhibition of peroxidase enzyme

Answer 53

Thioureas (Thionamides)