pharmo Flashcards
Which of the following statements most accurately describes the action of ACE inhibitors on the glomerular filtration pressure?
vasodilation of the efferent arteriole
normal stroke volume range
55-100
factors affecting stroke volume
Cardiac size
Contractility
Preload
Afterload
how do you calculate stroke volume
It is calculated by subtracting the end systolic volume from the end diastolic volume.
what integers with the absorption of ACEI reducing its therapeutic effect?
Antacids interfere with the absorption of ACE-inhibitors, reducing its therapeutic effect. Low dose aspirin is safe to use in patients on ACE-inhibitors.
what drugs are zero order pharmokinetics
Key examples of zero-order drugs are salicylates (aspirin), phenytoin, ethanol, and fluoxetine.
Amitriptyline, ampicillin, apixaban and atenolol all display first-order kinetics.