Pharmacy Flashcards
Deals with biological, biochemical, and economic features of natural meds?
Pharmacognosy
Preparation, dispensing, and proper use of meds?
Pharmacy
Study of dosages and the criteria that influence it?
Posology
Study of the action or the effects of medications on living organisms?
Pharmacodynamics
Uses of meds in the treatment of disease?
Pharmacotherapeutics
Study of poisons?
Toxicology
Science of treating disease by any method that will relieve pain, treat, or cure infections?
Therapeutics
Therapeutics may use what treatment method other than medications?
Radiological treatment, diathermy, hydrotherapy
What text sets the standards for the quality, purity, strength and provides standards for medication?
United States Pharmacopeia & National Formulary (USP-NF)
What designates the USP-NF as the official reference for medications marketed in the US?
The U.S. Federal Food, Medication, and Cosmetics Act
How is the reference Drug Facts and Comparisons organized?
Therapeutic medications class
What reference contains quick and concise medication info?
Drug Information Handbook
What is known as the “blue bible” of pharmacology for its wide use in American pharmacies?
Remington: The Science and Practice of Pharmacy
The term “dosage range” is applied what?
The minimum and maximum amount to produce the desired effect
What term describes the least amount of medication required to produce therapeutic effect?
Minimum dose
What term describes the largest amount of medication that can be given without reaching the toxic effect?
Maximum dose
What is the least amount of medication that will produce symptoms of poisoning?
Toxic dose
What term is used to describe the normal adult dose?
Therapeutic dose
What is a minimum lethal dose?
Least amount of med that can produce death
What are the two primary factors affecting dosage?
Age (most common), weight
How is Young’s Rule expressed?
Age in years over age in years plus 12 multiplied by normal adult
What has more direct bearing on the dose than any other factor?
Weight
How is Clark’s Rule expressed?
Pt weight in lbs over 150 times adult dose
Injections may require ________ doses than oral meds?
smaller
What two methods of administration are closely associated with oral administration?
Sublingual, Buccal
What are pyrogens?
Products of the growth of microorganisms
Parenteral meds are examined at least what 3 times?
Reception of solution, periodically, immediately before use
Unless stated on the label, parenteral solutions must be free of what?
Turbidity or undissolved material
Inhalation is divided into what three major types?
Vaporization, Gas Inhalation, Nebulization (med converted to fine spray via compressed gas)
Topically applied meds serve what two purposes?
Local effect, systemic effect
What are the 6 “rights” of patient medication administration?
Patient, Medication, Dose, Route, Time, Documentation
What is a MAR?
Medication administration record
Medications normally have what 3 names?
Chemical, Generic, Brand/Trade
Astringents cause ______ of the skin?
Shrinkage
Aluminum Acetate solution (Burrow’s Solution, Domeboro) is used as what?
Wet to dry dressing for the relief of inflammatory conditions of the skin
What is used as a topical astringent and protectant to blistered, raw, or oozing areas of the skin?
Calamine lotion
Bland or fatty substances applied to skin to make it more pliable and soft?
Emollients
What is the generic name for cocoa butter?
Theobroma oil
Zinc Oxide is a white petrolatum emollient containing what percentage of zinc oxide powder?
Approximately 20%
Expectorants are more accurately known as what?
Bronchomucotropic agents
Guaifenesin and codeine phosphate (Robitussin AC) relieve symptoms of what?
Common cold (may cause dependency)
What is used to relieve Eustachian tube congestion?
Nasal decongestants
What is HCL?
Pseudophedrine Hydrochloride
Actifed is the trade name for HCL and Triprolidine Hydrochloride which reduces congestion and?
Swelling of mucous membranes
What is the generic name for Mucinex D?
Pseudophedrine and Guaifenesin
This drug is used for motion sickness, nighttime sleep aid, urticaria, and allergic rhinitis?
Diphenhydramine HCL (Benadryl)
Chlor-Trimeton is used for what?
Symptomatic treatment of urticaria
Dimenhydrinate (Dramamine) may control nausea/vomiting in connection with?
Radiation sickness
What medication is used to treat GERD?
Ranitidine (Zantac)
Histamine H2 Receptor Antagonists are effective in preventing complications of?
Peptic ulcer disease
A low PH may cause the intestinal tract to become?
Excessively acidic
Oral medications normally should not be taken within ______ hours of taking an antacid?
Two
Is used to reduce phosphate absorption in patients with chronic renal failure?
Magnesium Hydroxide (Milk of Magnesia)
Magnesium Hydroxide (Milk of Magnesia) should be taken on an empty stomach with lots of fluid, and therefore should not be given in the presence of what?
Abdominal pain, nausea, vomiting
Magnesium Hydroxide (Milk of Magnesia) may have a laxative effect and prolonged use may cause?
Kidney stones
Although it may cause constipation, the major advantage to Aluminum Hydroxide Gel (Amphojel) is what?
No systemic alkalosis is produced
Alumina (Maalox) coats the stomach lining and is better than Amphojel for what reason?
Less constipating
Antiseptics _______ growth of microorganisms?
Suppress
Germicides ______ susceptible organisms?
Kill
Disinfectants are primarily _______ in their action?
Germicidal
What is the standard by which all other antiseptic agents are measured for effectiveness?
Phenol (carbolic acid)
High concentration of Phenol can cause what?
Tissue destruction
Phenol is inactivated by what?
Alcohol
What does Betadine release into the skin?
Free iodine
Isopropyl Alcohol is used in what percentage as a skin antiseptic?
70% solution
Hexachlorophene (pHisoHex) is a neurotoxin agent effective against gram-positive organisms. What decreases its effectiveness?
Presence of pus or serum
pHisoHex should not be used on what?
Premature infants, denuded skin, burns, or mucous membranes
Residual amounts of pHisoHex can be removed with what?
Alcohol
Glutaraldehyde (Cidex) is used to sterilize materials that are not resistant to heat and is effective against what kind of gram positive/negative bacteria?
Vegatative
Hydrogen Peroxide is normally available in ____ % solution and is effective against what dental condition known as trench mouth?
3%, NUG
In a solid form, this is most commonly used to cauterize mucous membranes and to treat aphthous ulcers?
Silver Nitrate
What is the most common side effect of Silver Nitrate?
Causes the skin to turn black
Silver Nitrate in liquid form is used to prevent what in newborns?
Gonorrheal ophthalmia
What happens if a wet dressing of Silver Nitrate dries out?
Turns the skin slate grey, a condition known as argyria
Prior to penicillin, what was the first effective chemotherapeutic agent available in safe dosage ranges?
Sulfonamides
What year were penicillins introduced?
1941
Sulfisoxazole (Gantrisin) is a ______ sulfonamide used to treat UTIs?
Bacteriostatic
Trimethoprim and Sufamethoxazole (Bactrim, Septra) is an ______ sulfonamide used to treat UTIs?
anti-infective
Sulfacetamide Sodium (Sodium Sulamyd, Bleph-10 _______ bacteriostatic used to treat conjunvtivitis?
Ophthalmic
Silver Sulfadiazine (Silvadene Creme) is topical antimicrobial agent used to treat what?
Second and third degree burns
Penicillins are derived from what?
Molds on bread and fruit
What is Penicillin’s mechanism of action?
Inhibit cell wall synthesis during the reproductive phase of bacterial growth
Penicillin G, Aqueous is administered how?
Parenteral IV only
Penicillin G, Benazathine (Bicillin LA) is injected into a large muscle to treat syphilis and upper respiratory infections caused by what group of bacteria?
Streptococcal Group-A
What has a longer duration of action than most other penicillins?
Penicillin G Procaine, Aqueous (Wycillin)
What is usually the drug of choice for uncomplicated group-A beta-hemolytic streptococcal infections?
Penicillin V Potassium (tablets of powder)
Dicloxacillin Sodium (Dynapen) is used to treat what?
Penicillin-G resistant staphylococci
What is used to treat shigella, salmonella, e-coli, gonorrhea?
Ampicillin (Polycillin)
Amoxicillin (Amoxil) is preferred over Ampicillin due to its effectiveness against what?
Shiggella (has more complete absorption)
Amoxicillin and Clavulante potassium (Augmentin) is used to treat many different infections caused by?
Bacteria
Cephalosporin C is an antimicrobial agent of what origin?
Fungal
What percentage of patients allergic to penicillin may also be allergic to cephalosporin?
5-16%
Cephalosporin antibiotics are generally divided into how many generations?
Three
What is unique about third generation cephalosporin agents?
They have a much broader gram-negative spectrum than earlier generations
What is used preoperatively to reduce the chance of certain infections following surgical procedures?
Cefazolin Sodium (Ancef, Kefzol)
What cephalosporin is used to treat infection of the respiratory tract, otitis media, skin and genitourinary system?
Cephalexin (Keflex)
What are mixed infections?
Infections that include both aerobic and anaerobic pathogenic organisms
What was the first truly broad spectrum antibiotics?
Tetracyclines (introduced in 1948)
What is the tetracycline’s most important mechanism of action?
Blocking the formation of polypeptides used in protein synthesis
What is the most common side effect of tetracyclines?
Mild gastrointestinal disturbances (not indicated for children or pregnant women)
Why should children and pregnant women not take tetracyclines?
Discolors teeth and depresses bone marrow growth
Why should tetracyclines not be administered with milk products, antacids and iron preparations?
They combine with metal ions to form non-absorbable compounds
Tetracycline HCL (Achromycin, Sumycin) is indicated for what?
Rocky Mountain spotted fever, typhus fever, and severe acne
When should Tetracycline HCL be given?
1 hr before and 2 hrs after meals
Doxycycline Hyclate (Vibramycin) has a low affinity for binding with calcium, is used for malaria prophylaxis and what else?
Uncomplicated chlamydial and gonococcal infections