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Collective Deck > Pharmacology--Toxicities > Flashcards

Pharmacology--Toxicities Flashcards

1
Q

Antidote: acetaminophen

A

N-AC (replenishes glutathione)

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2
Q

Antidote: AChE inhibitors, organophosphates

A

Atropine followed by pralidoxime

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3
Q

Antidote: amphetamines (basic)

A

NH4Cl (acidify urine)

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4
Q

Antidote: antimuscarinic, anticholinergic agents

A

physostigmine salicylate, control hyperthermia

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5
Q

Antidote: benzodiazepines

A

flumazenil

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6
Q

Antidote: b blocker

A

glucagon

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7
Q

Antidote: carbon monoxide

A

100 % Oxygen, hyperbaric O2

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8
Q

Antidote: Cu, As, Au

A

Penicillamine

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9
Q

Antidote: cyanide

A

nitrite + thiosulfate, hydroxocobalamin (forms stable cyanocobalamin)

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10
Q

Antidote: digitalis

A

Anti Dig Fab fragments

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11
Q

Antidote: heparin

A

protamine sulfate

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12
Q

Antidote: iron

A

Deferoxamine, deferasirox

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13
Q

Antidote: lead

A

EDTA, dimercaprol, succimer, penicillamine

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14
Q

Antidote: mercury, arsenic, gold

A

Dimercaprol (BAL), succimer

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15
Q

Antidote: methylene glycol, ethylene glycol

A

Fomepezole > ethanol or dialysis

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16
Q

Antidote: methemoglobin

A

methyline blue, vitC

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17
Q

Antidote: opioids

A

naloxone

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18
Q

Antidote: salicylates

A

NaHCO3 (alkalinize urine), dialysis

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19
Q

Antidote: TCAs

A

NaHCO3 (plasma alkalinization)

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20
Q

Antidote: tPA, streptokinase, urokinase

A

Aminocaproic acid

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21
Q

Antidote: warfarin

A

VitK, plasma (fastest reversal for active bleeding)

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22
Q

Coronary vasopasm

A

cocaine, sumatriptan, ergot alkaloids

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23
Q

cutaneous flushing

A

VANC: vancomycin, adenosine, Niacin, Ca2+ channel blockers

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24
Q

dilated cardiomyopathy

A

danorubicin, doxirubicin

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25
Q

Torsades de points

A

Class 3 antiarrhythmics (sotalol) and class IA (quinidine); macrolid antibiotics, antipsychotics, TCAs

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26
Q

adrenocortical insufficiency

A

HPA suppression 2nd to glucocorticoid withdrawal

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27
Q

hot flashes

A

tamoxifen, clomiphene

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28
Q

hyperglycemia

A

tacrolimus, protease inhibitors, niacin, HCTZ, B blockers, corticosteroids (taking pills necessitates having blood checked)

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29
Q

hypothyroidism

A

lithium, amiodarone, sulfonamides

30
Q

acute cholestatic hepatitis, jaundice

A

erythromycin

31
Q

diarrhea

A

Might Excite Colon On Accident: metformin, erythromycin, colchicine, orlistat, acarbose

32
Q

Focal to massive hepatic necrosis

A

liver HAVAc: halothane, amanita phalloides (mushroom), valproic acid, acetaminophen

33
Q

hepatitis

A

INH

34
Q

pancreatitis

A

Drugs Causing A Violent Abdominal Distress: didanosine, corticosteroids, alcohol, valproic acid, azathioprine, diuretics (furosemide, HCTZ)

35
Q

agranulocytosis

A

Drugs CCCrush Myeloblasts and Promyelocytes: Dapsone, clozapine, carbamezepine, colchicine, methimazole, PTU

36
Q

aplastic anemia

A

Cant Make New Blood Cells Properly: carbamazepine, methimazole, NSAIDs, Benzene, chloramphenicol, PTU

37
Q

direct coombs+ hemolytic anemia

A

methydopa, penicillin

38
Q

gray baby syndrome

A

chloramphenicol

39
Q

hemolysis in G6PD deficiency

A

hemolysis IS D PAIN: INH, sulfonamides, dapsone, primaquine, aspirin, ibuprofen, nitrofurantoin

40
Q

Megaloblastic anemia

A

have a blast with PMS: phenytoin, methotrexate, sulfa drugs

41
Q

thrombocytopenia

A

heparin, cimetidine

42
Q

thrombotic complications

A

OCPs (estrogens)

43
Q

fat redistribution

A

Fat PiG: protease inhibitors, glucocorticoids

44
Q

gingival hyperplasia

A

phenytoin, verapamil, cyclosporine, nifedipine

45
Q

hyperuricemia (gout)

A

Painful Tophi and Feet Need Care; pyrazinamide, thiazides, furosemide, niacin, cyclosporine

46
Q

myopathy

A

fibrates, niacin, colchicine, hydroxychloroquine, IFN alpha, penicillamine, statins, glucocorticoids

47
Q

Osteoporosis

A

corticosteroids, heparin

48
Q

Photosensitivity

A

sulfonamides, amiodarone, tetracyclines, 5 FU (SAT For Photo)

49
Q

Stevens Johnson’s syndrome

A

Steven Johnson has epileptic Allergy to Sulfa drugs and Penicillin: anti epileptic drugs (carbamazepine, ethosuximide, lamotrigine, phenytoin, phenobarbital), allopurinol, sulfa drugs, penicillin

50
Q

SLE like syndrome

A

lupus is “SHIPP-E”: sulfa drugs, hydralazine, INH, procainamide, phenytoin, etanercept

51
Q

teeth discoloration

A

tetracyclines

52
Q

tendonitis, tendon rupture, cartilage damage

A

tetracyclines esp in elderly

53
Q

cinchonism

A

quinidine, quinine

54
Q

parkinson-like snydrome

A

cogwheel rigidity of ARM: antipsychotics, reserpine, metoclopramide

55
Q

seizures

A

I BITE My tongue: INH (B6 deficiency), buproprion, imipenem/cilastatin, tramadol, enflurane, metoclopramide

56
Q

tardive dyskinesia

A

antipsychotics, metoclopramide

57
Q

diabetes insipidus

A

lithium, demclocycline

58
Q

fanconi syndrome

A

Expired tetracycline

59
Q

hemorrhagic cystitis

A

cyclophosphamide, ifosfamide (prevent with mesna)

60
Q

intersitial nephritis

A

methicillin, NSAIDs, furosemide

61
Q

SIADH

A

Can’t Concentrate Serum Sodium: carbamazepine, cyclophosphamide, SSRIs

62
Q

Dry cough

A

ACE inhibitors

63
Q

Pulmonary fibrosis

A

Breathing Air Badly from Meds: bleomycin, amiodarone, busulfan, methotrexate

64
Q

Antimuscarinic

A

atropine, TCAs, H1 blockers, antipsychotics

65
Q

Disulfiram like reaction

A

metronidazole, certain cephalosporins, griseofulvin, procarbazine, 1st gen sulfonyureas

66
Q

nephrotoxicity/ototoxicity

A

aminoglycosides, vancomycin, loop diuretics, cisplatin

67
Q

P450 inducers

A

Chronic alcoholic Mona steals Phen-Phen and Never REfuses Greasy Carbs: chronic alcohol, modafinil, St Johns wort, Phenytoin, phenobarbital, nevirapine, rifampin, griseofulvin, carbamazepine

68
Q

P450 substrates

A

Always (X4) think when starting others: anti epileptics, antidepressants, antipsychotics, anesthetics, theophylline, warfarin, statins, OCPs

69
Q

P450 inhibitors

A

A cute Gentleman “Cipped” Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon Rolls: Acute alcohol abuse, gemfibrozil, ciprofloxacin, INH, grapefruit juice, quinidine, amiodarone, ketoconazole, macolides, sulfonamides, cimetidine, ritonavir

70
Q

Sulfa drugs:

A

probenecid, furosemide, acetazolamide, celecoxib, thiazides, sulfonamide anbx, sulfsalazine, sulfonylureas (Popular FACTSSS)

Collective Deck (17 decks)

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