Important Cancer Markers Flashcards by joie Evans | Brainscape

Q

What is the normal function of BRCA1/2

A

DNA repair genes

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Q

What is the normal function of APC/beta-catenin

A

Want signaling pathway

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Q

What is the normal function of TP53

A

Genomic stability

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Q

What is the normal function of RB

A

Gi/S transition inhibitor

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Q

What is the normal function of WT1

A

Urogenital differentiation

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Q

What is the normal function of VHL

A

Ubiquitin ligase component

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Q

What is the normal function of RAS

A

GTP-binding protein

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Q

What is the normal function of MYC

A

Transcription factor

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Q

What is the normal function of ERBB1 (EGFR)

A

Receptor tyrosine kinase

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Q

What is the normal function of ERBB2 (HER2)

A

Receptor tyrosine kinase

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Q

What is the normal function of ABL

A

Nonreceptor tyrosine kinase

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Q

What is the normal function of BRAF

A

Ras signal transduction

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Q

What can mutations of RAS cause

A

Cholangiocarcinoma, pancreatic adenocarcinoma

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Q

What can mutations of MYC cause

A

Burkitt lymphoma

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Q

What can mutations of ERBB1 (EGFR) cause

A

Lung adenocarcinoma

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Q

What can mutations of ERBB2 (HER2) cause

A

Breast cancer

Q

What can mutations of ABL cause

A

Chronic myelogenous leukemia

Q

What can mutations of BRAF cause

A

Hairy cell leukemia, melanoma

Q

What can mutations of VHL cause

A

Renal cell carcinoma, von-hippel-Lindau syndrome

Q

What can mutations of WT1 cause

A

Wilms tumor

Q

What can mutations of Rb cause

A

Retinoblastoma, osteosarcoma

Q

What can mutations of TP53 cause

A

Most cancers, Li-fraumeni syndrome

Q

What can mutations of APC/beta-catenin cause

A

Colon, gastric and pancreatic cancer; familial adenomatous polyposis

Q

What can mutations of BRCA1/2 cause

A

Breast and ovaria cancer