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(First Aid) + Pharm + (Secrets) > Pharmacology--Toxicities > Flashcards

Pharmacology--Toxicities Flashcards

1
Q

Antidote: acetaminophen

A

N-AC (replenishes glutathione)

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2
Q

Antidote: AChE inhibitors, organophosphates

A

Atropine followed by pralidoxime

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3
Q

Antidote: amphetamines (basic)

A

NH4Cl (acidify urine)

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4
Q

Antidote: antimuscarinic, anticholinergic agents

A

physostigmine salicylate, control hyperthermia

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5
Q

Antidote: benzodiazepines

A

flumazenil

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6
Q

Antidote: b blocker

A

glucagon

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7
Q

Antidote: carbon monoxide

A

100 % Oxygen, hyperbaric O2

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8
Q

Antidote: Cu, As, Au

A

Penicillamine

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9
Q

Antidote: cyanide

A

nitrite + thiosulfate, hydroxocobalamin (forms stable cyanocobalamin)

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10
Q

Antidote: digitalis

A

Anti Dig Fab fragments

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11
Q

Antidote: heparin

A

protamine sulfate

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12
Q

Antidote: iron

A

Deferoxamine, deferasirox

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13
Q

Antidote: lead

A

EDTA, dimercaprol, succimer, penicillamine

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14
Q

Antidote: mercury, arsenic, gold

A

Dimercaprol (BAL), succimer

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15
Q

Antidote: methylene glycol, ethylene glycol

A

Fomepezole > ethanol or dialysis

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16
Q

Antidote: methemoglobin

A

methyline blue, vitC

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17
Q

Antidote: opioids

A

naloxone

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18
Q

Antidote: salicylates

A

NaHCO3 (alkalinize urine), dialysis

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19
Q

Antidote: TCAs

A

NaHCO3 (plasma alkalinization)

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20
Q

Antidote: tPA, streptokinase, urokinase

A

Aminocaproic acid

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21
Q

Antidote: warfarin

A

VitK, plasma (fastest reversal for active bleeding)

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22
Q

Coronary vasopasm

A

cocaine, sumatriptan, ergot alkaloids

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23
Q

cutaneous flushing

A

VANC: vancomycin, adenosine, Niacin, Ca2+ channel blockers

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24
Q

dilated cardiomyopathy

A

danorubicin, doxirubicin

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25
Torsades de points
Class 3 antiarrhythmics (sotalol) and class IA (quinidine); macrolid antibiotics, antipsychotics, TCAs
26
adrenocortical insufficiency
HPA suppression 2nd to glucocorticoid withdrawal
27
hot flashes
tamoxifen, clomiphene
28
hyperglycemia
tacrolimus, protease inhibitors, niacin, HCTZ, B blockers, corticosteroids (taking pills necessitates having blood checked)
29
hypothyroidism
lithium, amiodarone, sulfonamides
30
acute cholestatic hepatitis, jaundice
erythromycin
31
diarrhea
Might Excite Colon On Accident: metformin, erythromycin, colchicine, orlistat, acarbose
32
Focal to massive hepatic necrosis
liver HAVAc: halothane, amanita phalloides (mushroom), valproic acid, acetaminophen
33
hepatitis
INH
34
pancreatitis
Drugs Causing A Violent Abdominal Distress: didanosine, corticosteroids, alcohol, valproic acid, azathioprine, diuretics (furosemide, HCTZ)
35
agranulocytosis
Drugs CCCrush Myeloblasts and Promyelocytes: Dapsone, clozapine, carbamezepine, colchicine, methimazole, PTU
36
aplastic anemia
Cant Make New Blood Cells Properly: carbamazepine, methimazole, NSAIDs, Benzene, chloramphenicol, PTU
37
direct coombs+ hemolytic anemia
methydopa, penicillin
38
gray baby syndrome
chloramphenicol
39
hemolysis in G6PD deficiency
hemolysis IS D PAIN: INH, sulfonamides, dapsone, primaquine, aspirin, ibuprofen, nitrofurantoin
40
Megaloblastic anemia
have a blast with PMS: phenytoin, methotrexate, sulfa drugs
41
thrombocytopenia
heparin, cimetidine
42
thrombotic complications
OCPs (estrogens)
43
fat redistribution
Fat PiG: protease inhibitors, glucocorticoids
44
gingival hyperplasia
phenytoin, verapamil, cyclosporine, nifedipine
45
hyperuricemia (gout)
Painful Tophi and Feet Need Care; pyrazinamide, thiazides, furosemide, niacin, cyclosporine
46
myopathy
fibrates, niacin, colchicine, hydroxychloroquine, IFN alpha, penicillamine, statins, glucocorticoids
47
Osteoporosis
corticosteroids, heparin
48
Photosensitivity
sulfonamides, amiodarone, tetracyclines, 5 FU (SAT For Photo)
49
Stevens Johnson's syndrome
Steven Johnson has epileptic Allergy to Sulfa drugs and Penicillin: anti epileptic drugs (carbamazepine, ethosuximide, lamotrigine, phenytoin, phenobarbital), allopurinol, sulfa drugs, penicillin
50
SLE like syndrome
lupus is "SHIPP-E": sulfa drugs, hydralazine, INH, procainamide, phenytoin, etanercept
51
teeth discoloration
tetracyclines
52
tendonitis, tendon rupture, cartilage damage
tetracyclines esp in elderly
53
cinchonism
quinidine, quinine
54
parkinson-like snydrome
cogwheel rigidity of ARM: antipsychotics, reserpine, metoclopramide
55
seizures
I BITE My tongue: INH (B6 deficiency), buproprion, imipenem/cilastatin, tramadol, enflurane, metoclopramide
56
tardive dyskinesia
antipsychotics, metoclopramide
57
diabetes insipidus
lithium, demclocycline
58
fanconi syndrome
Expired tetracycline
59
hemorrhagic cystitis
cyclophosphamide, ifosfamide (prevent with mesna)
60
intersitial nephritis
methicillin, NSAIDs, furosemide
61
SIADH
Can't Concentrate Serum Sodium: carbamazepine, cyclophosphamide, SSRIs
62
Dry cough
ACE inhibitors
63
Pulmonary fibrosis
Breathing Air Badly from Meds: bleomycin, amiodarone, busulfan, methotrexate
64
Antimuscarinic
atropine, TCAs, H1 blockers, antipsychotics
65
Disulfiram like reaction
metronidazole, certain cephalosporins, griseofulvin, procarbazine, 1st gen sulfonyureas
66
nephrotoxicity/ototoxicity
aminoglycosides, vancomycin, loop diuretics, cisplatin
67
P450 inducers
Chronic alcoholic Mona steals Phen-Phen and Never REfuses Greasy Carbs: chronic alcohol, modafinil, St Johns wort, Phenytoin, phenobarbital, nevirapine, rifampin, griseofulvin, carbamazepine
68
P450 substrates
Always (X4) think when starting others: anti epileptics, antidepressants, antipsychotics, anesthetics, theophylline, warfarin, statins, OCPs
69
P450 inhibitors
A cute Gentleman "Cipped" Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon Rolls: Acute alcohol abuse, gemfibrozil, ciprofloxacin, INH, grapefruit juice, quinidine, amiodarone, ketoconazole, macolides, sulfonamides, cimetidine, ritonavir
70
Sulfa drugs:
probenecid, furosemide, acetazolamide, celecoxib, thiazides, sulfonamide anbx, sulfsalazine, sulfonylureas (Popular FACTSSS)

(First Aid) + Pharm + (Secrets) (36 decks)

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