Key Associations Part 2 Flashcards
Holosystolic murmur
VSD, tricuspid regurgitation, mitral regurgitation
Hypercoagulability, endothelial damage, blood stasis
Virchow triad (results in venous thrombosis)
Hypertension, secondary
Renal disease
Hypoparathyroidism
Accidental excision during thyroidectomy
Hypopituitarism
Pituitary adenoma (usually benign tumor)
Infection secondary to blood transfusion
Hep C
Infectionsin chronic granulomatous disease
Staphylococcus aureus, E coli, Aspergillus (catalase +)
Intellectual disability
Down syndrome, fragile X syndrome
Kidney stone
Calcium: radiopaque
Struvite (ammonium): radiopaque (formed by urease + organisms such as Proteus vulgaris or Staphylococcus)
Uric acid: radiolucent
Late cyanotic shunt (uncorrected left to right becomes right to left)
Eisenmeger syndrome (caused by ASD, VSD, PDA: results in pulmonary HTN/polycythemia)
Liver disease
Alcoholic cirrhosis
Lysosomal storage disease
Gaucher disease
Male cancer
Prostatic carcinoma
Malignancy associated with noninfectious fever
Hodgkin lymphoma
Malignancy (kids)
ALL, neuroblastoma (cerebellum)
Metastases to bone
Prostate, breast > lung > thyroid
Metastasis to brain
Lung > breast > genitourinary > melanoma > GI
Metastasis to liver
Colon»_space; stomach, pancreas
Mitochondrial inheritance
Disease occurs in both males and females, inherited through females only
Mitral valve stenosis
Rheumatic heart disease
Mixed (UMN and LMN) motor neuron disease
Amyotrophic lateral sclerosis
Myocarditis
coxsackie B virus
Nephrotic syndrome (adults)
Focal segmental glomerulosclerosis
Nephrotic syndrome (kids)
Minimal change disease
Neuron migration failure
Kallman syndrome (hypogonadotropic, hypogonadism and anosmia)
Nosocomial pneumonia
Klebsiella, E coli, Pseudomonas aeruginosa
Obstruction of male urinary tract
BPH
Opening snap
mitral stenosis
Opportunistic infection in AIDs
PCP pneumonia
Osteomyelitis
S aureus
Osteomyelitis in sickle cell disease
Salmonella
Osteomyelitis with IV drug use
Pseudomonas, S aureus
Ovarian metastases from gastric carcinoma or breast cancer
Krukenberg tumor (mucin secreting signet ring cells)
Ovarian tumor (benign, bilateral)
Serous cystadenoma
Ovarian tumor (malignant)
Serous cystadenocarcinoma
Pancreatitis (acute)
Gallstones, alcohol
Pancreatitis (chronic)
Alcohol (adults), cystic fibrosis (kids)
Patient with ALL/CLL/AML/CML
ALL: child, CLL: adult > 60, AML: adult ~65, CML: adult 30-60
Pelvic inflammatory disease
Chlamydia trachomatis, Neisseria gonorrhoeae
Philadelphia chromosome t(9:22) (bcr-abl)
CML (may sometimes be associated with ALL/AML)
Pituitary tumor
Prolactinoma, somatotropic “acidophilic” adenoma
Primary amenorrhea
Turner syndrome (45, XO)
Primary bone tumor (adults)
Multiple myeloma
Primary hyperaldosteronism
Adenoma of adrenal cortex
Primary hyperPTH
Adenomas, hyperplasia, carcinoma
Primary liver cancer
Hepatocellular carcinoma (chronic hepatitis, cirrhosis, hemochromatosis, alpha1-antitrypsin deficiency)
Pulmonary HTN
COPD
Recurrent inflammation/thrombosis of small/medium vessels in extremeties
Buerger disease (strongly associated with tobacco)
Renal tumor
Renal cell carcinoma: associated with von Hippel-Landau and cigarette smoking; paraneoplastic syndromes (EPO, renin, PTH, ACTH)
Right heart failure due to a pulmonary cause
Cor pulmonale
S3 (protodiastolic gallop)
Increased ventricular filling (left to right shunt, mitral regurg, LV failure [CHF])
S4 (presystolic gallop)
Stiff/hypertrophic ventricle (aortic stenosis, restrictive cardiomyopathy)
Secondary hyperPTH
Hypocalcemia of chronic kidney disease
Sexually transmitted disease
Chlamydia (usually coninfected with gonorrhea)
SIADH
Small cell carcinoma of the lung
Site of diverticula
Sigmoid colon
Sites of atherosclerosis
Abdominal aorta > coronary artery > popliteal artery > carotid artery
Stomach cancer
Adenocarcinoma
Stomach ulcerations and high gastrin levels
Zollinger-Elson syndrome (gastrinoma of the duodenum or pancreas)
t(14,18)
Follicular lymphomas (bcl2 activation, IgH translocation)
t(8;14)
Burkitt Lymphoma (c-myc activation, IgH)
t(9;22)
Philadelphia chromosome, CML (bcr-abl fusion)
Temporal arteritis
Risk of ipsilateral blindness due to thrombosis of ophthalmic artery; polymyalgia rheumatica
Testicular tumor
Seminoma (malignant, radiosensitive)
Thyroid cancer
Papillary carcinoma
Tumor in women
Leiomyoma (estrogen dependent, not precancerous)
Tumor of infancy
Hemangioma (usually regresses spontaneously by childhood)
Tumor of the adrenal medulla (adults)
Pheochromocytoma (usually benign)
Tumor of the adrenal medulla (kids)
Neuroblastoma (malignant)
Type of Hodgkin
Nodular sclerosis (vs mixed cellularity, lymphocytic predominance, lymphocytic depletion)
Type of non-Hodgkin
Diffuse large cell
UTI
E coli, Staphylococcus saprophyticus (young women)
Viral encephalitis affecting temporal lobe
HSV-1
Vitamin deficiency (US)
Folate (pregnant women are at high risk; body stores only 3-4 mo supply; prevents neural tube defects)