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Pharmacology Sympathetic Antagonists MOA Flashcards

1
Q

Irreversiblyblocks a1 and a2 indirect baroreflex activation

A

Phenoxybenzamine

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2
Q

Reversibly blocks a1 and a2

A

Phentolamine

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3
Q

Blocks a1, not a2

A

Prazosin, doxazosin, terazosin

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4
Q

Slightly selective for a1A

A

Tamsulosin

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5
Q

Blocks a2
Elicits inc central sympathetic activity
Inc norepinephrine release

A

Yohimbine

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6
Q

Blocks B and a1

B>a1 block

A

Labetalol

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7
Q

Block B1 and B2

A

Propranolol
Nadolol
Timolol

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8
Q

Block B1> B2

A 
Metroprolol
Atenolol
Alprenolol
Betaxolol
Nebivolol
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9
Q

Lower HR and BP
Reduce renin
Safer in asthma

A

Block B1> B2

MAABN
Metoprolol
Atenolol
Alprenolol
Betaxolol
Nebivolol
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10
Q

Lower HR and BP
Reduce renin
Maybe CI in asthma

A

Propranolol
Nadolol
Timolol

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11
Q

Lowers BP

HR rises due to baroreflex activation

A

Phenoxybenzamine

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12
Q 
Blocks a-mediated vasoconstriction
Lowers BP
Inc HR (baroreflex)
A

Phentolamine

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13
Q

Alpha 1 selective used to lower BP

A

Prazosin
Doxazosin
Terazosin

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14
Q

Blockade may relax prostatic SM more than vascular SM

A

Tamsulosin

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15
Q

Lowers BP with limited HR inc

A

Labetalol

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16
Q

Used for pheochromocytoma and high catecholamine states

A

Phenoxybenzamine

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17
Q

Used for htn and BPH

A

Prazosin
Doxazosin
Terazosin

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18
Q

Used for BPH

A

Tamsulosin
Prazosin
Doxazosin
Terazosin

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19
Q

Used for male erectile dysfunction

20
Q

Propranolol
Nadolol
Timolol used for

A 
Htn
Angina pectoris
Arrhythmias
Migraine
Hyperthyroidism
21
Q 
Metoprolol
Atenolol
Alprenolol
Betaxolol
Nevivolol used for
A

Angina pectoris
Hypertension
Arrhythmias

22
Q

Irreversible blocker of alpha receptors

A

Phenoxybenzamine

23
Q

Duration of effect of phenoxybenzamine

24
Q

Adv of bradycardia
Fatigue
Vivid dreams
Cold Hands

A 
Metoprolol
Atenolol
Alprenolol
Betaxolol
Nevivolol
25
Q

Toxicity of propranolol
Nadolol
Timolol

A 
Bradycardia
Worsened asthma
Fatigue
Vivid dreams
Cold hands
26
Q

Blocks B2> B1

A

Butoxamine

27
Q

Blocks B1B2 with intrinsic sympathomimetic (partial agonist) effect

A 
Pindolol
Acebutolol
Carteolol
Bopindolol
Oxprenolol
Celiprolol
28
Q

B > a1 block

A

Bucindolol

29
Q

B1>B2

30
Q

Blocks tyrosine hydrolase

Reduces synthesis of dopamine, norepinephrine, epineprhine

A

Metyrosinase

31
Q

Inc peripheral resistance

A

butoxamine

32
Q

Very brief cardiac blockade

33
Q

Lowers BP, modestly lowers HR

A 
Pindolol
Acebutolol
Carteolol
Bopindolol
Oxprenolol
Celiprolol
Penbutolol
34
Q

Lowers BP

Central nervous system may elicit extrapyramidal effects (due to low dopamine)

A

Metyrosine

35
Q

No clinical indication

A

Butoxamine

36
Q 
Pindolol
Acebutolol
Carteolol
Bopindolol
Oxprenolol
Celiprolol
Penbutolol
A

Hypertension
Arrhythmias
Migraiine
May avoid worsening of bradycardia

37
Q

Used for heart failure

A

Carvedilol
Medroxalol
Bucindolol

38
Q

Rapid contorl of BP, arrythmias, thyrotoxicosis, myocardial ischemia intraoperatively

39
Q

Used for pheochromocytoma

A

Phenoxybenzamine (block a1 and a2)
Phentolamine (block a vasoconstriction)
Metyrosine (tyrosine hydroxylase inhibitor)

40
Q

Tyrosine hydroxylase inhibitor

A

Metyrosine

41
Q

Toxicity of butoxamine

A

Asthma provocation

42
Q 
Toxicity of 
Pindolol
Acebutolol
Carteolol
Bopindolol
Oxprenolol
Celiprolol
Penbutolol
A

Fatigue
Vivid dreams
Cold hands

43
Q

Toxicity of
Carvedilol
Medoxalol
Bucindolol

44
Q

Toxicity of esmolol

A

Bradycardia, hypotension

45
Q

Metyrosine toxicity

A

EPS, orthostatic hypotension, crystalluria

Medicine (29 decks)

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