Pharmacology Qs Flashcards
Which drug class could be considered for patient with depression who has suicide ideation? [1]
Why? [1]
SSRIs: safe in overdose
Which drug class used to treat depression has the biggest risk of overdose? [1]
Explain why [1]
TCAs: cause delayed repolarisation of QT interval which can lead to ventricular fibrillation
Statins inhibit which enzyme? [1]
Why are statins with short half lifes given at pre-sleep? [1]
HMG Co-A Reductase: most active at night
What is rare, but recognised AE of statin use? [1]
Why is this clinically significant? [1]
Muscle toxicity: patients with risk of rhabdomyolysis should be prescribed statins wit care
What test should be given before prescribing a statin to a patient with renal or liver impairment? [1]
Test creatine kinase levels
State if each of the voltage-dependent ion channel classes (sodium, potassium and calcium) are commonly targeted by drugs. [3]
Calcium channels are targets - for the treatment of hypertension for example.
Sodium channels are targets - for treatment of epilepsy and to provide local anaesthesia for example.
But, voltage-dependent potassium channels are very rarely targeted
State a risk factor that increases the risk of seratonin syndrome [1]
When two or more serotonergic medicines are prescribed concomitantly
E.g. tramadol and sertraline
What is medicines reconciliation? [1]
What does medicine reconciliation ensure? [1]
Clozapine
Which cardiac drug should be stopped in renal impairment? [1]
Digoxin
Which drug class may it not be appropriate to re-start treatment at the dose prescibed given a peroid of cessation? [1]
ACE inhibitors
Why is methadone given as once daily dosing? [1]
Why is methadone dose dependent per patient? [1]
Long half-life (12-18 hrs)
Depends on patient’s tolerance to heroin
What are three key considerations when asking about asthma control? [3]
Which drugs should not be given in monitored dosage systems (MDS)? [3]
Name 5 drugs / classes which will require investigative work to establish when the next dose is due
