Clinical Kinetics Flashcards
1
Q
Which three parameters define the characteristics of PK? [3]
A
Vol of distribution
Half life
Clearance
2
Q
A
3
Q
Which factors influence the bioavailbility of a drug? [5]
A
4
Q
What is the 1/2 life of this drug?
A
5
Q
A
6
Q
A
7
Q
How do you calculat volume of distribution? [1]
A
8
Q
Describe how drugs that are highly water soluble and highly lipid soluble have different Vd [2]
A
9
Q
Describe how Vd is differnet in children, older and dehydrated and pregant/ oedema patients [3]
A
10
Q
When does protein binding become important?
A
11
Q
How do you calculate Vd; Elimination rate constant (K); & 1/2 life [3]
A
12
Q
Give four examples that routine therapeutic drug monitoring occurs in [4]
Why? [1]
A
Digoxin
Gentamicin
Lithium salts
Vancomycin
Have narrow therapetuic windows
13
Q
A
14
Q
A
