Formulation and Administration Flashcards
What is alendronic acid indicated for?
Alendronic acid: bisphosphinate; osteoporosis
Why must you NOT crush alendronic acid? [1]
Name a condition that diclofenac is contraindicated in [1]
Post-Stroke: increases risk of arterial thrombotic events if long term treatment
What is important to note about crushing drugs [2]
If the drug is prescribe as a modified release, then crushing can destroy the modified release mechansim
Give 5 examples of parenteral routes for medication
How do alter vancomycin if it C.diff infection compared to systemic infection?
Hidden excipients:
Name a pathology that below medication is contraindicated in and why [2]
Aspartarme
Hidden excipients:
Name a pathology that below medication is contraindicated in and why [2]
phenobarbitol
Contains alcohol to help dissolve drug; don’t give to child
Hidden excipients:
Name a pathology that below medication is contraindicated in and why [2]
Syrups
Also in diabetic patients
What are the 4 stages of how a body handles a drug? [4]
ADME
Administration
Distrubution
Metabolism
Excretion
Name 4 examples of a drug and a mineral that cause drug not to be absorbed / absorbed less due to chelation [4]
Describe the MoA of colestyramine
binding bile acids, preventing their reabsorption; this promotes hepatic conversion of cholesterol into bile acids; the resultant increased LDL-receptor activity of liver cells increases the clearance of LDL-cholesterol from the plasma.
What is colestyramine indicated for? [3]
Hyperlipidaemias / high cholesterol
Pruritus associated with partial biliary obstruction and primary biliary cirrhosis
Diarrhoea associated with Crohn’s disease, ileal resection, vagotomy, diabetic vagal neuropathy, and radiation
What is important to note about colestyramine prescription? [1]
How do you alter dosing because of this? [1]
Binds to other medications taken at same time
Give other medication 1hr before OR 4-6 hrs after colestyramine