Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

SCRIPT: Pharmacology > Formulation and Administration > Flashcards

Formulation and Administration Flashcards

1
Q

What is alendronic acid indicated for?

A

Alendronic acid: bisphosphinate; osteoporosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Why must you NOT crush alendronic acid? [1]

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Name a condition that diclofenac is contraindicated in [1]

A

Post-Stroke: increases risk of arterial thrombotic events if long term treatment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is important to note about crushing drugs [2]

A

If the drug is prescribe as a modified release, then crushing can destroy the modified release mechansim

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Give 5 examples of parenteral routes for medication

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How do alter vancomycin if it C.diff infection compared to systemic infection?

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Hidden excipients:
Name a pathology that below medication is contraindicated in and why [2]

Aspartarme

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Hidden excipients:
Name a pathology that below medication is contraindicated in and why [2]

phenobarbitol

A

Contains alcohol to help dissolve drug; don’t give to child

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Hidden excipients:
Name a pathology that below medication is contraindicated in and why [2]

Syrups

A

Also in diabetic patients

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the 4 stages of how a body handles a drug? [4]

A

ADME
Administration
Distrubution
Metabolism
Excretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Name 4 examples of a drug and a mineral that cause drug not to be absorbed / absorbed less due to chelation [4]

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Describe the MoA of colestyramine

A

binding bile acids, preventing their reabsorption; this promotes hepatic conversion of cholesterol into bile acids; the resultant increased LDL-receptor activity of liver cells increases the clearance of LDL-cholesterol from the plasma.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is colestyramine indicated for? [3]

A

Hyperlipidaemias / high cholesterol

Pruritus associated with partial biliary obstruction and primary biliary cirrhosis

Diarrhoea associated with Crohn’s disease, ileal resection, vagotomy, diabetic vagal neuropathy, and radiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is important to note about colestyramine prescription? [1]

How do you alter dosing because of this? [1]

A

Binds to other medications taken at same time

Give other medication 1hr before OR 4-6 hrs after colestyramine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which patient population are MR preperations contra-indicated in? [1]

A

Ptxs with bowel resections (e.g. ileostomy)

17
Q

Which patient population do enteric coated preperations need careful consideration with ? [1]

A
18
Q

Name a factor that influences IM drug absorption [1]

A

Blood flow to the muscle: very well perfused muscle has high ab.

19
Q

Name two drugs that have dramatically different oral and IV dosing [2]

Describe why this is the case

A
20
Q

Describe the half-life of morphine and how this influences dosing

A

Short half life (2-4hrs)
Need to prescribe every 4hrs to so not making pain

21
Q

Name a drink that ciprofloxin

A

Milk: Calcium ions form insoluable chelates with ciprofloxacin, making it because sub-therapeutic

22
Q
A
23
Q
A
24
Q
A
25
Q
A
26
Q

When should levothyroxine be adminstered? [1]

A

Before breakfast

27
Q

When should simvastatin be administered? [1]

A

At night

28
Q

What advice should you give when prescribing alendronic acid about taking the drug? [1]

A

Take on an empty stomach: food alters the therapeutic effect

29
Q

State and explain 3 medicines where administering is important at specific times [3]

A

Antimicrobials:
- Need to achieve therapetuic concentration to tx infection. If not evenly distributed may fall and become sub-therapeutic

Insulin

Nitrates: should be prescribed that there is a nitrate free period of at least 8hrs. Prevents tolerance

Modified release morphine: due to short half-life need to top up doses

Timolol eye drops: short 1/2 life. Failure may cause glaucoma being too dificult to treat

30
Q

Enteral feeds are given over a lengthy period of time (20-24hrs). Most medicines are fine to administer via the feed.

But how do you alter this if the feed does reduce the absoprtion of the medicine?

A
31
Q

Enteral feeds are given over a lengthy period of time (20-24hrs). Most medicines are fine to administer via the feed.

But what if the feed requires the absorption of the medicine, and the medicine is needed to be given frequently? [1]

A
32
Q

Why are some medications given subcut? [1]

A

Little blood flow; means that get slow absorption

33
Q

Name two conditions where IM injections are contraindicated [1]

A

Thrombocytopenia
Clotting disorders

SCRIPT: Pharmacology (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions