Pharmacology of reward Flashcards
The nucleus accumbens (the major component of the ventral striatum), the amygdala, hippocampus, lateral hypothalamus, and prefrontal cortex, all receiving dopaminergic innervation from cell bodies in midbrain
_____________.
ventral tegmental area.
Final common pathway of reinforcement and reward is hypothesized to be the mesolimbic dopamine pathway ie. ________
ventral tegmental area to nucleus accumbens.
Drugs that reliably produce intense feelings of _______ or relief of a negative effect are more likely to be abused due to these reinforcing properties
pleasure (euphoria)
All drugs with significant dependence liability share the pharmacologic property of enhancing dopamine activity in the ________
nucleus accumbens:
The abuse liability of a drug is increased with an increase in the rapidity of the ________
onset of effect
Delivery of drugs by _________ is preferred by users of cocaine, nicotine, and cannabis. Because discernible CNS effects can be obtained within as few as 7 seconds
Inhalation
Most dangerous route with greatest potential for exaggerated reactions, introduction of infectious agents or contaminants, and overdose toxicity is _____
Intravenous
The _______ & _______routes are associated with the most rapid rise in brain levels of the drug and a greater likelihood to produce addiction.
intravenous,
inhalational
drugs with the _______ half-lives tend to have higher abuse liabilities
shortest
Orbitofrontal nucleus in prefrontal cortex projects to nucleus accumbens, plays role in ___________
regulating impulses
Dorsolateral nucleus in prefrontal cortex projects to nucleus accumbens, plays role in _______
analysis of situation
Ventromedial nucleus in prefrontal cortex projects to nucleus accumbens, plays role in _______
integration with emotions
