Pharmacology of Pain Flashcards
what pain do C neurones stimulate
- sharp and prickling
what pain do A neurones stimulate
- sore, dull, aching and heavy
what is the function of analgesia
the suppression of the sensation of pain from - spinal cord - thalamus - cerebral cortex and reaction to pain - cerebral cortex - other limbic areas
what are the main effects of an opioid analgesic
CNS
- depression of cough reflex
- depression of respiratory centres, vasomotor centre
- stimulates vomiting
PNS
- decreased mobility
- increased tone of GI tract and closure of sphincters
list the opiod receptors
- mu
- kappa
- sigma
- delta
- epsilon
what is the therapeutic use of an analgesic
relief of visceral and traumatic pain
what is the therapeutic use of anxiolytic
allay anxiety in dying
what is the therapeutic use of antitussive
surpasses cough
what is the therapeutic or relief dyspnoea
stabilise breathing
what are the 2 classifications of opioid drugs and give an example
- Morphine Analogues e.g. morphine, heroine
2. Synthetic Derivitus e.g. fentanyl
what is a morphine-like opioid agonist
acts primarily on U receptors to decrease activity of neurones in
- slowing gut
- respiratory
- perception of pain
what is the use of an opioid antagonist
- treatment in opioid overdose
- restores respiration
what is a prostaglandin
inflammatory mediators and pain receptor stimulates
what is the function of an anti-pyretic analgesic
reduce the synthesis of prostaglandins
list 2 examples of nocioceptive and inflammatory pain
- osteoarthritis
- cancer
