Juvenile Idiopathic Arthritis (JIA) Flashcards
Define Innate Immune defences
prevent foreign substances from entering the body
Define Adaptive Immune Defences
T and B lymphocytes become tolerant to self, and react to non self by targeting and destroying antigens
define autoimmune disease
breakdown in the ability of adaptive defences to distinguish from self and non self
describe what happens in cell mediated cytotoxicity
Cytotoxic T cells lyse target cells and phagocytes kill cells by releasing digestive enzyme
how are symptoms of autoimmune diseases relieved
NSAID’s
what treatment is used to replace vital symptoms of autoimmune diseases
hormone replacement e.g. insulin
what treatments are used for autoimmune diseases for the suppressed immune system
corticosteroids to control disease and preserve organs
role of fibroblasts
lubricating compounds
role of macrophages
remove debris
role of chondrocytes
turn over cartilage matrix
role of osteoclasts
break down bone
symptoms of JIA
- joint pain and swelling
- joint stiffness
- flexion contracture
- gait issues
- sleep disturbance
- periods of remission and flare ups
list the extra articular manifestations of JIA
- acute phase response e.g. fever, malaise
- serositis
- uveitis
- growth failure
Serositis
damage to the heart and lung structures = pain
- dry eyes and mouth
- nerve pain
Uveitis
inflammation of the uvea (eye)
- long term = blindness
- treated by topical corticosteroids
