Pharmacology of pain 3 ; NSAIDS/DMARDS Flashcards
paracetemol, aspirin, naproxen are examples of which type of drug?
a. NSAIDS
b. DMARDS
c. opiods
a.NSAIDS
High doses of NSAIDS can be toxic to what organ?
a. kidney
b. liver
c. heart
d. lungs
b.liver
signs of inflammation
a. pain,redness, heat, swollen, loss of function
b. pain, deformity, bruising
c. pain,heat,redness
a.pain,redness, heat, swollen, loss of function
what are NSAIDS used to treat?
a. inflammation,fever,pain,muscle injury,sprains,fractures
b. fever, pain, muscle injury, sprains , fractures
c. inflammation,fever,pain,muscle injury,sprains,fractures, infection
inflammation, fever,pain, muscle injury, sprains ,factures
which drug has this mechanism of action?
inhibition of the COX 1 and 2 , lowers levels of prostoglandins (cox converts arachadonic acid to prostoglandins)
aNSAIDS
b. DMARDS
c. Opiods
a. NSAIDS
what enzymes are inhibited by NSAIDS
a. COX1
b. COX 1 and 2
c. COX 2 and COX 3
b.COX 1 and COX 2
What is the role of cox 1 and 2 that NSAIDS inhibit?
a. convert prostoglandins to arachadonic acid
b. convert arachadonic acid to prostoglandins
b.convert arachadonic acid to prostoglandins
which drugs lower arachdonic acid level by inhibiting lipocortin? (higher up chain)
a.NSAIDS
bAnalgesics
c.corticosteroids
d.paracetemol
c.corticosteroids
what do prostaglandins do?
a. cause swelling, pain , vasodilation
b. cause swelling, pain and vasoconstriction
c. cause swelling pain and bleeding
a. swelling, pain (bradykinin mediated nociception), vasodilation
which enzyme is purposely inhibited to reduce inflammation
a. cox 1
b. lipocortin
c. cox 2
cox 2
what is the role of cox 1
a. platelet aggregation, regulation of kidney blood flow, protection of the gastric mucosa
b. expressed in inflammatory cells to activate them
a. platelet aggregation
regulation of kidney blood flow
protection of gastric mucosa
what does cox 2 do ?
a. platelet aggregation, regulation of kidney blood flow, protection of the gastric mucosa
b. expressed in inflammatory cells to activate them
b. in response to mediators it activates inflammatory cells, expressed in inflammatory cells
which cox enzyme is found all over the body
a. 1
b. 2
a.1
blocking which enzyme gives side effects of NSAIDS
a. cox 1
b. cox 2
c. cox 1 and 2
a.cox 1
which cells have high cox 2
a. eiosinophils and baso
b. neutor and baso
c. eiosin and neutro
a.eiosinophils and baso
which of these are the correct set of properties for NSAIDS?
a. antibiotic, anti pyretic
b. anti inflammatory, analgesic, anti pyretic
c. anti inflammatory, analgesic
d. analgesic, anti pyretic
b.anti inflammatory , analgesic and anti pyretic (fever)
main side effects of what drug include gastric irritation
- compromised renal blood flow
- increased bleeding
- increase risk of MI
a. opiods
b. DMARDS
c. corticosteroids
d. NSAIDS
d. NSAIDS
Why are NSAIDS anti inflam?
a. inhibition of COX 1
b. inhibition of COX2
c. inhibition of dihydrooroate dehydrogenase
d. inhibition of dihydrofolate reductase
a.inhibition of cox 2
decreased prostoglandins
decreased blood flow
decreased pain
decreased swelling
patient with inflam arthiritis which drug most useful?
a. NSAID
b. opiod
c. corticosteroid
a. NSAIDS
NSAIDS do not affect…
a. pain
b. cause of inflammation
c. inflammation
d. fever
b.cause of inflammation
drug used for ora facial pain
post op pain
bone metasteses in cancer
inflam arthiritis
a. DMARDS
b. NSAIDS
c. corticosteroids
d. simple analgesics
b.NSAIDS
how do NSAIDS reduce pain?
a. Decreased prostaglandins, reduced bradykinin nociception
b. decreased prostaglandins, decreased blood flow, decreased swelling
c. decreased prostaglandin production in the hypothalamus, vasodilation and sweating decreased temp
a. decreased prostaglandins, reduced bradykinin nociception
in what conditions are NSAIDS used to reduce pain?
arthiritis, muscle pain, toothace, postpartum pain, cancer metastasus in bone pain and headaches
how do NSAIDS reduce fever?
a. Decreased prostaglandins, reduced bradykinin nociception
b. decreased prostaglandins, decreased blood flow, decreased swelling
c. decreased prostaglandin production in the hypothalamus, vasodilation and sweating decreased temp
c. decreased prostaglandin production in the hypothalamus, vasodilation and sweating to decrease temp
how do NSAIDS have their anti pyretic effect?
a. Decreased prostaglandins, reduced bradykinin nociception
b. decreased prostaglandins, decreased blood flow, decreased swelling
c. decreased prostaglandin production in the hypothalamus, vasodilation and sweating (COX 3)decreased temp
d. .release of endotoxins , increased IL-1 from macrophages , increased prostaglandins in hypothalamus via COX
decreased PG production in hypothalamus, vasodilation and sweating (COX3) decreased temp
*no effect on normal body temp
which enzyme is indicated in sweating
a. cox 1
b. cox 2
c. cox 3
c.cox 3
how does aspirin have anti platelet effect?
a. Decreased prostaglandins, reduced bradykinin nociception
b. decreased prostaglandins, decreased blood flow, decreased swelling
c. decreased prostaglandin production in the hypothalamus, vasodilation and sweating decreased temp
d. inhibition of cox 1
d, COX 1 inhibition
what is aspirin used for?
a.stroke prevention, MI prevention, unstable angina ,DVT prevention
b. reducing pain in arthritis, muscle pain, toothache, dysmenorrhea
postpartum pain, cancer metastasis in bone pain
c.reducing fever
a. stroke prevention
MI prevention
unstable angina
DVT prevention
why are there a lot of side effects of NSAIDS?
a. inhibit cox 2
b. inhibit cox 1
c. reduce prostaglandin levels
b.inhibit housekeeping cox 1
3 main side effects of nsaids
GI disturbances, adverse renal effects, liver toxicity
GI effects of NSAIDS?
perforations, ulcers, bleeds , diarrhoea, nausea, constipation, vomiting
who are most affected by GI effects of NSAIDS
a. young people
b. pregnant women
c. elderly taking long term NSAIDS for arthiritis
d. people with chronic hypertension
c.elderly taking long term NSAIDS for arthiritis