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CANN > Pharmacology of Migraine Medicaiton > Flashcards

Pharmacology of Migraine Medicaiton Flashcards

1
Q

What is the MOA of ergot alkaloid migraine medications?

A

Bind 5-HT1 and alpha receptors and cause major vasoconstriction

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2
Q

What is the first line Triptan for migraine treatment?

A

Sumatriptan

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3
Q

True/False. Patients may have different responses to different Triptans. Failure of one does not indicate failure of another.

A

True

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4
Q

What is an absolute contraindication for use of ergot alkaloids?

A

Pregnancy

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5
Q

What is the only Triptan that may be used for preventative treatment of migraine?

A

Frovatriptan

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6
Q

These drugs may be used for acute treatment of migraines when triptans fail or are contraindicated.

A

Small-molecule CBRP receptor antagonists - Ubrogepant, Atogepant, Rimegepant

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7
Q

What are the ergot alkaloid migraine medications?

A

Ergotamine, dihydroergotamine

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8
Q

What class of drugs is the first line for migraine acute treatment?

A

Triptans

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9
Q

Triptans are contraindicated in what patients?

A

Patients with coronary artery disease or peripheral vascular diseases

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10
Q

What ADRs are associated with CBRP antagonists?

A

Drowsiness, pain at injection site, constipation

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11
Q

What are the pathophysiologic changes associated with the headache phase of migraine?

A

Vasodilation and neurogenic inflammation

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12
Q

True/False. CBRP antagonists should be avoided in pregnant women and patients with heart conditions

A

False - CBRP antagonists are indicated in pregnant women and patients with heart conditions that cannot take 5HT-1 agonists

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13
Q

What is the most important neuropeptide involved in migraine disorders?

A

Calcitonin-Gene Related Peptide (vasodilator)

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14
Q

What drugs are most commonly used for preventative migraine treatment?

A

Anticonvulsants, beta blockers

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15
Q

What is the MOA of CBRP antagonists for migraine treatment?

A

Blocks pain transmission and neurogenic inflammation

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16
Q

What is the use of monoclonal antibodies in migraine treatment?

A

Last-effort preventative treatment that blocks the CBRP receptor site

17
Q

Dizziness and drowsiness are associated with which anti-migraine medication?

A

Lasmiditan

18
Q

What small-molecule CBRP receptor antagonists may be used for preventative migraine treatment?

A

Atogepant, Rimegepant - longer half lives

19
Q

This class of serotonin receptors promotes vasoconstriction and prevents neuropeptide release.

A

5-HT1

20
Q

What characteristic distinguishes Lasmiditan from other 5-HT1 agonists?

A

Only blocks neuropeptide release, does not have vasoconstriction properties

21
Q

Chest-related symptoms are most associated with what migraine medication?

A

Triptans - due to vasoconstriction

22
Q

What beta blocker is most commonly used for preventative migraine treatment?

A

Propanolol

CANN (42 decks)

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