Pharmacology of Glucocorticoids

Question 1

Mineralocorticoid:

Answer 1

Aldosterone

Question 2

Synthesis inhibitor drugs:

Answer 2

Aminoglutethimide
Abiraterone
Metyrapone
Ketoconazole

Question 3

What does Aminoglutethimide inhibit?

Answer 3

Pregnenolone synthesis

Question 4

What does Aminoglutethimide inhibit?

Answer 4

Pregnenolone synthesis

Question 5

What does ketoconazole inhibit?

Answer 5

Side chain synthesis

Question 6

What does Metyrapone inhibit?

Answer 6

11-hydroxylation

Question 7

What is mifepristone?

Answer 7

Steroid receptor inhibitor

Question 8

What is mifepristone?

Answer 8

Steroid receptor inhibitor

Question 9

Natural glucocorticoids:

Answer 9

Hydrocortisone

Question 10

Mineralocorticoids:

Answer 10

Deoxycorticosterone

Fludrocortisone

Question 11

Inhaled glucocorticoids:

Answer 11

Fluticasone

Budesonide

Question 12

Inhaled glucocorticoids:

Answer 12

Fluticasone

Budesonide

Question 13

Addison’s disease replacement therapy acute and long term?

Answer 13

Acute:
A.) hydrocortisone
B.) hydrocortisone + fludrocortisone
Chronic therapy:
Hydrocortisone with increase dosage for times of physical stress

Question 14

What is used in therapy for aldosterone deficiency?

Answer 14

Fludrocortisone

Question 15

What does Aminoglutethimide do?

Answer 15

Inhibit formation of Pregnenolone from cholesterol

Question 16

What is Aminoglutethimide used to treat?

Answer 16

Inhibitor therapy for estrogen-sensitive breast cancer

Question 17

What is Abiraterone used to treat?

Answer 17

Refractory prostate cancer

Question 18

What is the only drug for Cushing syndrome pregnancy use?

Answer 18

Metyrapone

Question 19

What is ketoconazole used to treat?

Answer 19

Cushing syndrome

Question 20

Mifepristone uses?

Answer 20

Cushing syndrome
Morning after pill
Anti-androgen