Pharmacology of anti-inflammatories and immune suppression Flashcards
Rubor=
redness
calor=
heat
tumor=
swelling
dolor=
pain
cardinal signs of inflammation (4)
redness
heat
swelling
pain
NSAID stands for
non steroidal anti-inflammatory
made side effects of NSAIDs related to
GI
COX1 inhibitors—>
stop formation of platelets
COX2 inhibitors—>
anti-inflammatory
2nd generation NSAID called
Coxibs
what is different about second generation NSAIDs
selective COX-2 inhibitors
what are NO-SAIDs
nitric oxide donating NSAID
what is different about NO-SAIDs
have GI protective effect and increased anti-inflammation
SAID=
Glucocorticoids
e.g of SAIDs (2)
Hydrocortisone
prednisolone
what do glucocorticoids do
decrease IL-2, IL-3, IL-4, TNF alpha
side effect of glucocorticoids
cushing’s syndrome
name 2 immunosuppresant drugs
cyclosporine
tacrolimus
what is the most important effect of immunosuppression drugs
IL-2 gene reduction
