Pharmacology of Anti-Inflammatories

Question 1

What are the five cardinal signs of inflammation?

Answer 1

Redness
Swelling
Heat
Pain
Loss of function

Question 2

What are the two types of inflammation?

Answer 2

Acute Inflammation

Chronic Inflammation

Question 3

Give 3 examples of preformed mediators of acute inflammation found within a cell

Answer 3

Histamine
Serotonin
Lysosomal enzymes

Question 4

Give 5 examples of newly synthesised mediators of acute inflammation found within a cell

Answer 4

Prostaglandins
Leukotrienes
NO
Cytokines
Platelet activating factors

Question 5

Describe the pharmacology of Aspirin

Answer 5

Non-selective irreversible COX-1 and COX-2 inhibitor

Question 6

Which COX enzyme targeted by Aspirin is particularly important for inflammation?

Answer 6

COX-2

Question 7

State 4 NSAID drugs

Answer 7

Aspirin
Ibuprofen
Paracetamol
Diclofenac

Question 8

Give examples of 3 Corticosteroid drugs

Answer 8

Hydrocoristone
Prednisolone
Dexamethadone

Question 9

SAID drugs are based on what endogenous compound?

Answer 9

Adrenal steroids, synthesised from Cholesterol

Question 10

How do steroid drugs work?

Answer 10

Drug binds to the steroid receptor complex, and crosses the nuclear membrane. Once it binds to specific genes, it controls the expression

Question 11

Give 3 examples immuno-supressive drugs

Answer 11

Cyclosporine A
Tacrolimus
Rapamycin