Cellular Components of Blood Flashcards
What two things is blood plasma comprised of?
Serum and Clotting Factors
What is serum?
Blood plasma with the clotting factors removed
State the six innate immune cells found within blood
Neutrophils Monocytes Natural Killer cells Mast cells Eosinophils Basophils
State the two adaptive immune cells found within blood
T Lymphocytes
B Lymphocytes
State 6 methods of analysing blood
Spectrometry Impedance Cytochemistry Flow cytometry Microscopy Immunoassays
In the developing embryo, early definitive haematopoiesis occurs where?
In the yolk sac
Describe what happens in Early Definitive Haematopoiesis
Haemangioblasts from the undifferentiated mesoderm give rise to vascular endothelial cells and HSCs. Haemangioblasts form haemangioblastic aggregates and “blood islands”, leading to capillary formation
Which growth factor regulates platelet production
Thrombopoietin
From birth, which region in the body stops haematopoiesis?
Liver
From biggest to least, which regions of the body undergoes haematopoiesis postnatally?
Vertebra / Pelvis Sternum Rib Femur Tibia
The oxygen-haemoglobin dissociation curve is a plot of what versus what?
Saturated Haemogobin vs. Oxygen Tension
What structure does Foetal haemoglobin have?
2y + 2a
What is the life span of an erythrocyte?
100 - 200 days
What is the role of Spectrin?
Forms the scaffold maintaining the integrity and shape of RBC membrane
What is the role of Ankyrin?
Achoring of anion channels to Spectrin skeleton of RBC
