Pharmacology for the eye Flashcards
What are the 7 things a vet should know about drugs for the eyes?
- How to control pain to examine cornea
- Routes for medications to infiltrate ocular
structures - Selection of topical ocular and systemic anti‐
infectives - Topical antivirals for active herpes
- Selection of topical anti‐inflammatories &
immunosuppressive drugs - Medication to change pupil diameter
- Medication to reduce pressure in anterior
chamber
What topical drug can be used to control pain to examine the cornea?
- Local anaesthetic drops = lignocaine opthalmic drops. Rapid onset and duration of around 30-120 mins.
- This may be insufficient due to the severity of pain. Sedation or general anaesthesia may be required
What barriers are there in the eye?
- Blood-ocular barriers -> the blood-aquesous barrier and the blood-retinal barrier
What is an amphipathic drug?
Able to cross lipid and water
What are the three routes of topical ocular and systemic administration?
- Across the cornea
- Absorption by conjuntival blood vessels that flow into the ciliary body
- Drug exit via nasolacrimal duct
What are the three routes of topical ocular and systemic administration?
- Across the cornea
- Absorption by conjuntival blood vessels that flow into the ciliary body
- Drug exit via nasolacrimal duct
For topical formulations, how much drug is required to be effective?
- Only 10 – 25 uL are retained in conjunctival fornix & tear film after immediate overflow
- Commercial droppers deliver 25 – 50 µL of drug formulation / drop -> thus 1 drop is sufficient
- Best to use less more frequently
- After 5 minutes only 20% of drug remains on the ocular surface (as some drug may go through cornea, absorbed by blood vessels or goes out nasolacrimal drainage into the mouth).
How would you treat a sterile corneal ulcer?
Using proteinase inhibitors such as tetracycline or acetylcysteine drops to inhibit corneal proteolytic activity
How would you treat a traumatic or infected corneal ulcer in a dog?
Use an ointment that covers gram positives and gram negatives (something like tricin).
- Gram positives = bacitracin
- Gram negatives = polymixin or aminoglycosides
How would you treat a traumatic or infected corneal ulcer in a dog?
Use an ointment that covers gram positives and gram negatives (something like tricin).
- Gram positives = bacitracin
- Gram negatives = polymixin or aminoglycosides
What is the issue with using topical tetracycline eye ointment?
- Topical tetracyclines can irritate the cornea
- Currently only available through compounding pharmacies
How would you treat ocular signs associated with mycoplasma felis?
- Tetracycline ointment OR systemic therapy such as orla doxy or fluoroquinolones
How would you treat ocular chlamydiosis?
- Treated as for Mycoplasma spp.
- Tetracycline ointment OR systemic therapy such as orla doxy or fluoroquinolones
- NOTE: Doxycycline can be administered to kittens and pups > 4 weeks old without enamel discolouration
What are the topical anti-viral eye formulations that are available?
- Trifluridine - irritates cornea
- idoxuridine - drops do not penetrate the conjunctiva and cornea well except where there is ulceration
- cidofovir - BID drops. Carcinogenic.
Can antivirals eradicate latent infections?
- They are virostatic ‐ this means they are only effective in treating actively replicating virus and cannot eradicate latent infections