Muscle path Flashcards
Explain the structure of muscle
- Myofibres (muscle cells) - Long, multinucleate giant cells. Contractile proteins: Myofibrils made of actin and myosin
- Satellite cells (reserve cells or resting myoblasts)
- Endomysium: CT surrounding myofiber
- Perimysium: CT surrounding groups of myofibres
- Epimysium: CT surrounds whole muscle and is continue with fascia
- Huge blood supply
- Skeletal muscles insert via tendons (usually onto bones)
- Different types of myofibres: 1, 2a, 2b, Fast, slow, Rate of fatigue
- Skeletal muscle requires innervation
What are satellite cells?
reserve cells or resting myoblasts - when we see skeletal muscle degeneration its usually the resting myoblasts
What is the perimysium?
CT surrounding groups of myofibres
What is the endomysium?
CT surrounding myofibres
What is the epimysium
CT surrounds whole muscle and is continue with fascia
What aer the common causes of muscle atrophy?
Catabolism or disuse
Common cause of hypertropy
Increased use
What are the two adaptive changes to muscle cell injury?
Atrophy and hypertrophy
What do you expect to see in muscular necrosis?
- Segmental cell death
- Hyaline degeneration
- granular degeneration
What microscopic changes are considered to be reversible cell injury?
- Swelling
- vacuolation
- fatty change
If sarcolemma (cell membrane) is intact, what kind of regeneration would you expect to see?
o If sarcolemma (cell membrane) remains intact, regeneration of myofiber will occur through satellite cell proliferation
If sarcolemma (cell membrane) is NOT intact, what kind of regeneration would you expect to see?
o If not, fibrosis predominates: Cell injury → necrosis → mononuclear cell infiltrate → phagocytosis → repair (regeneration or fibrosis)
What musclar post mortem changes would you expect to see?
- Rigor mortis
- Colour changes - haemolysis, pallor (anaemia, exsanguination), dark colour (cachexia, congestion)
How do you detect muscle pathology?
- Physical examiation
- Serum biochem - (CK and AST)
- Biopsy (can be difficult)
- Functional studies
- Ultrastructural studies - not common
What is assoicatde with pallor?
Necrosis
Degeneration
Anaemia
Youth