Bone path 2 Flashcards

1
Q

What is an osteodystrophy? Give examples.

A

Any condition in which there is weakening of bone, often associated with abnormal Ca2+ metabolism which results in increased risk of pathological fractures.

Examples:
Classical osteodystrophies
- Rickets and osteomalacia
- Fibrous osteodystrophy
- Osteopaenua/osteoporosis

Toxic osteodystrophies
- Fluorine toxicity - fluorosis
- lead toxicity

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1
Q

What is an osteodystrophy? Give examples.

A

Any condition in which there is weakening of bone, often associated with abnormal Ca2+ metabolism which results in increased risk of pathological fractures.

Examples:
Classical osteodystrophies
- Rickets and osteomalacia
- Fibrous osteodystrophy
- Osteopaenua/osteoporosis

Toxic osteodystrophies
- Fluorine toxicity - fluorosis
- lead toxicity

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2
Q

Can fully grown animals develop rickets?

A

No, only growing animals can develop rickets.

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3
Q

What are the nutritional causes of osteopaenia/osteoporosis?

A
  • Starvation – most common in grazing animals
  • Calcium deficiency – seldom occurs naturally. Inadequate Ca2+ supplementation of lactating gilts
  • Phosphorus deficiency–more likely to cause rickets/osteomalacia Osteoporosis secondary to anorexia in P-deficient animals
  • Copper deficiency - Cu is component of lysyl oxidase -required for cross linkage of collagen. Impaired cross linkage → increased fragility of bone (+/-cartilage). Also interferes with osteoblastic activity –lesion resembles scurvy histologically. Focal thickening of physes –resembles rickets. Predisposes to osteochondrosis in deer
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4
Q

What is osteopetrosis?

A
  • Inherited defect in osteoclastic bone resorption -> solid bone with no marrow cavity
  • autosomal recessive inheritance
  • Reported in angus and simmental breeds of cattle, polypay lambs
  • Bones are more dense than normal but have reduce breaking strength
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5
Q

What would you expect to see in osteogenesis imperfecta?

A
  • Excessive bone fragility
  • important disease of humans and rare in animals
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