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Pharmacology > Pharmacology: Drug Reactions > Flashcards

Pharmacology: Drug Reactions Flashcards

1
Q

Coronary vasospasm

A

Cocaine

Sumatriptan

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2
Q

Cutaneous flushing

A 
VANC
Vancomycin
Adenosine
Niacin
CCB
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3
Q

Dilated cardiomyopathy

A

Doxorubicin (Adriamycin): intercalates DNA

Daunorubicin

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4
Q

Torsades de pointes

A 
Class III (sotalol)
Class IA (quinidine)
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5
Q

Agranulocytosis

A 
Agranulocytosis Could Certainly Cause Pretty Major Damage
Clozapine
CBZ
Colchicine
PTU
Methimazole
Dapsone
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6
Q

Aplastic anemia (BM failure)

A 
Chloramphenicol
Benzene
NSAIDs
PTU
Methimazole
Microtubule inhibitors: Vinblastine, paclitaxol
Antimetabolites: 5-FU, 6-MP, MTX
Antitumor abx: Etoposide
Other chemo: hydroxyurea
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7
Q

Hemolysis in G6PD pts

A 
Hemolysis IS PAIN in g6pD or Hemolysis IS a PAIN in the Dierriere!
Isoniazid
Sulfonamides
Primaquine/Chloroquine
Aspirin
Ibuprofen
Nitrofurantoin
Dapsone
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8
Q

Direct Coombs positive hemolytic anemia

A

Methyldopa

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9
Q

Megaloblastic anemia

A

having a blast with PMS
Phenytoin
MTX
Sulfa drugs

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10
Q

Gray baby syndrome

A

Chloramphenicol

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11
Q

Thrombotic complications

A

OCPs

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12
Q

Cough

A

ACE inhibitors (NOT ARBs)

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13
Q

Pulmonary fibrosis

A

tough to BLAB when you have pulmonary fibrosis
BLeomycin
Amiodarone
Busulfan

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14
Q

Acute cholestatic hepatitis

A

Erythromycin

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15
Q

Focal to massive hepatic necrosis

A

liver HAVAc
Halothane (inhaled anesthetic, also risk for malignant hyperthermia)
Acetominophen
VPA
Amantia phallodies (death cap mushroom, inhibits RNA pol II)

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16
Q

Hepatitis

A

INH

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17
Q

Pseudomembranous colitis

A

Clindamycin

Ampicillin (AMPed up PCN, HELPSS kill Enterococci)

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18
Q

Adrenocortical insufficiency

A

Glucocorticoid withdrawal (HPA suppression)

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19
Q

Gynecomastia

A 
Some Drugs Create AwesomE Knockers
Spirnolactone
Digoxin
Cimetidine
Alcohol
Estrogen
Ketoconazole
20
Q

Hot flashes

A

Tamoxifen: anti-estrogen in breast, pro-estrogen in uterus (partial on endometrium) and bone
Clomiphene

21
Q

Hypothyroidism

A

Lithium
Amiodarone
Sulfonamides

22
Q

Hyperglycemia

A

Niacin
Tacrolimus (immunosuppressant, also causes PRES!)
Protease inhibitors

23
Q

Fat redistribution

A 
Glucocorticoids
Protease inhibitors (NAVIR tease a protease!)
24
Q

Gingival hyperplasia

A

Phenytoin

Verapamil

25
Q

Gout

A 
Furosemide
Thiazides
Niacin
Cyclosporine
Pyrazinamide (anti-TB, inhibits mycolic acid production by inhibiting fatty acid synthase I)
26
Q

Myopathies

A

Fish N CHIPS Give you myopathies
Fibrates
Niacin
Colchicine
Hydroxychloroquine (aka Plaquenil): for RA, lupus
Interferon-alpha: block viral replication, used for Hep B/C, and Kaposi’s
Penicillinamine: heavy metal chelator (Pb, As, Au, Cu – vs. Fe is deferoxamine)
Statins
Glucocorticoids

27
Q

Osteoporosis

A

Corticosteroids

Heparin

28
Q

Photosensitivity

A

SAT for a photo
Sulfonamides/sulfa drugs
Amiodarone
Tetracycline

29
Q

Rash (SJS)

A 
bad rash after a PEC SLAPP
Penicillin
Ethosuximide
CBZ
Sulfa drugs
Lamotrigine
Phenytoin
Phenobarbital
30
Q

SLE-like syndrome

A 
it's not HIPP to have lupus
Hydralazine
INH
Procainamide
Phenytoin
Also: quinidine, minocycline, dapsone
31
Q

Tendonitis, tendon rupture, and cartilage damage (kids)

A

Fluoroquinolones

32
Q

Diabetes insipidus

A

Lithium (nephrogenic)

Demeclocycline (a tetrocycline abx - used to treat SIADH!)

33
Q

Fanconi’s syndrome

A

Expired tetracycline

34
Q

Interstitial nephritis

A

Methicillin
NSAIDs
Furosemide
Rifampin

35
Q

Hemorrhagic cystitis

A

Cyclophosphamide
Ifofosamide
(Give mesna)

36
Q

SIADH

A

CBZ: increases and potentiates ADH
Cyclophosphamide: direct effect on renal tubules, incr H2O retention

37
Q

Cinconchism (flushed, sweaty skin, tinnitus, blurred vision, lichenoid photosensitivity)

A

(AKA quinism, a pathological condition in humans caused by an overdose of quinine or its natural source, cinchona bark)
Quinidine
Quinine

38
Q

Parkinson-like syndrome

A

Anti-psychotics (DA antag)
Reserpine (inhibits VMAT)
Metoclopramide (dopamine D2 R antagonist in in the chemoreceptor trigger zone [CTZ], prevents N/V)

39
Q

Seizures

A

Bupropion (in bulimic patients)
Imipenem/cilastin (CNS toxicity at high levels)
Isoniazid

40
Q

Tardive dyskinesia

A

Antipsychotics

41
Q

Antimuscarinic (Hot/Red/Dry/Mad)

A

Atropine
TCAs
H1 blockers
Neuroleptics

42
Q

Disulfiram-like reaction

A

Metronidazole
certain Cephalosporins
Procarbazine (when combined with EtOH)
1st generation Sulfonylureas (tolbutamide, chlorpropamide)

43
Q

Nephrotoxicity/ototoxcity

A

Aminoglycosides
Vancomycin
Loop diuretics
Cisplatin

44
Q

Cholinergic

A

Digoxin

Organophosphates

45
Q

Lactic acidosis

46
Q

Check LFTs

A

Statins

TZDs (Pioglitazone, rosiglitazone)

46
Q

Sulfa drugs

A 
Popular FACTSSS
Probenecid (incr uric acid excretion)
Furosemide
Acetazolamide
Celecoxib
Thiazides
Sulfonamide antibiotics
Sulfasalazine
Sulfonylureas

Pharmacology (15 decks)

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