Pharmacology: Antibodies Flashcards
1
Q
Infliximab
A
Anti-TNF antibody
Tx: Crohn’s, RA, AS
Increased risk of infection (reactivation of TB), fever, hypotension
2
Q
Abiciximab
A
Antiplatelet
Monoclonal antibody against gp IIb/IIIa on activated platelets
3
Q
Trastuzumab
A
aka Herceptin
Monoclonal ab against HER-2 (erb-b2), a tyrosine kinase
- SE: cardiotoxic
4
Q
Imatinib
A
aka Gleevec
For CML, bcr-abl tyr kinase inhibitor
- SE: fluid retention
5
Q
Rituximab
A
Monoclonal ab against CD20 in B cells
- Used for nHL, RA
6
Q
Adalimumab
A
Anti-TNF antibody
Tx: Crohn’s, RA, AS, psoriasis
Increased risk of infection (reactivation of TB), fever, hypotension
7
Q
Ustekinumab
A
Inhibits differentiation and activation of CD4+ Th1 and Th17
Tx: Psoriasis
8
Q
Denosumab
A
Anti-RANKL antibody
- Prevents osteoclast activation by preventing RANKL interaction with RANK
- Similar action as OPG
- Decrease risk of bone loss and fracture in pts with bone mets
9
Q
Natalizumab
A
antibody against CAMs
