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Pharmacology > Pharmacology: GI agents > Flashcards

Pharmacology: GI agents Flashcards

1
Q

Cimetidine

A

H2 blocker, reversible
Decreases H+ secretion
Inhibits P450! Anti-androgen effects (gynecomastia)! Decr renal excr of Cr (along with ranitidine)

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2
Q

Ranitidine

A

H2 blocker, reversible
Decreases H+ secretion
Decr renal excr of Cr (along with cimetidine)

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3
Q

Famotidine

A

H2 blocker, reversible

Decreases H+ secretion

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4
Q

Nizatidine

A

H2 blocker, reversible

Decreases H+ secretion

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5
Q

Omeprazole

A

PPI

Irreversibly inhibits H+/K+ ATPase

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6
Q

Lansoprazole

A

PPI

Irreversibly inhibits H+/K+ ATPase

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7
Q

Bismuth

A

Binds to acid base, provides physical protection, allowing HCO3- secretion to reestablish pH gradient in mucosal layer

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8
Q

Sucralfate

A

Binds to acid base, provides physical protection, allowing HCO3- secretion to reestablish pH gradient

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9
Q

Misoprostol

A

PGE1 analog
Increases production and secretion of gastric mucosal barrier, decreases acid production
- Prevent NSAID ulcers, maintain PDA OPEN, induces labor

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10
Q

Octreotide

A

Long-acting SST analog

Tx: Acute variceal bleeds, acromegaly, VIPoma, carcinoid tumors

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11
Q

Atropine

A

Anti-muscarinic

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12
Q

Bethanechol

A

Cholinomimetic muscarinic agonist
Increases gastric acid secretion
Tx: ileus, urinary retention

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13
Q

Aluminum hydroxide

A

Antacid

SE: hypoK, constipation, hypophosphatemia, proximal muscle weakness, osteodystrophy, seizures

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14
Q

Magnesium hyroxide

A

Antacid, osmotic laxative
Provides osmotic load to draw water out
SEs: hypoK, diarrhea, hyporeflexia, hypotension, cardiac arrest

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15
Q

Calcium carbonate

A

Antacid

SE: hypoK, hyperCa

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16
Q

Magnesium citrate

A

Osmotic laxative

Provides osmotic load to draw water out

17
Q

Polyethylene glycol

A

Osmotic laxative

Provides osmotic load to draw water out

18
Q

Lactulose

A

Osmotic laxative
Provides osmotic load to draw water out
Also treats hepatic encephalopathy (gut flora degrades lactulose into lactic acid and acetic acid, provides acid to trap nitrogen as NH4+ and excrete)

19
Q

Infliximab

A

Anti-TNF
Tx: Crohn’s, RA
Increased risk of infection (reactivation of TB), fever, hypotension

20
Q

Sulfasalazine

A

Sulfapyridine (antibiotic) + 5-ASA
Activated by colonic bacteria
For Crohn’s

21
Q

Odansetrone

A

5-HT3 antagonist, central acting

For post-op vomiting and pts getting chemo

22
Q

Metoclopramide

A

D2 receptor antagonist, central and GI enteric acting

- Antiemetic and gastroprokinetic

Pharmacology (15 decks)

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