Pharmacology: Autonomic drugs Flashcards
Bethanechol
Direct cholinergic agonist
Carbachol
Direct cholinergic agonist
Pilocarpine
Direct cholinergic agonist
Methacholine
Direct cholinergic agonist
Neostigmine
Indirect cholinergic agonist (AChEI)
- No CNS penetration!
- For reversal of NMJ junction blockade (post-op)
Pyridostigmine
Indirect cholinergic agonist (AChEI)
- Myasthenia gravis
Edrophonium
Indirect cholinergic agonist (AChEI)
Physostigmine
Indirect cholinergic agonist (AChEI)
- Atropine OD
Echothiophate
Indirect cholinergic agonist (AChEI)
- Glaucoma (contricts pupil)
Donepezil
Indirect cholinergic agonist (AChEI)
- AD
Pralidoxime
Reactivates inhibited AchE
- Use with atropine for organophosphate poisoning
Atropine
Muscarinic antagonist - eye, airway, stomach, gut, bladder
Homatropine
Muscarinic antagonist - eye
Tropicamide
Muscarinic antagonist - eye
Benztropine
Muscarinic antagonist - CNS
- Dystonia
- Parkinson’s (2nd line, improves tremor, not rigidity and bradycardia)
Scopolamine
Muscarinic antagonist - CNS
Ipratropium
Muscarinic antagonist - lung
Oxybutynin
Muscarinic antagonist - GU
Glycopurrolate
Muscarinic antagonist - GU
- Reduce urgency in mild cystitis and reduce bladder spasms
Methscoplolamine
Muscarinic antagonist - GI
- PUD
Pirenzepine
Muscarinic antagonist - GI
- PUD
Propantheline
Muscarinic antagonist - GI
- PUD
Toxicity of anticholinergics
Hot, dry, red, blind, mad
- Hyperthemia
- Urinary retention
- Constipation
- Flushed skin (decr vasoconstriction)
- Cycloplegia
- Acute angle closer glaucoma
- Disorientation