PHARMACOLOGY - DRUG ASSOC

Question 1

serum sickness

drug causes
infection cause

Answer 1

drugs (haptens): penicillin, monoclonal AB
Infection: Hep B

Question 2

Partial agonists (4)

Answer 2

Buprenorphine
Clomiphene
Acbutolol / Pindolol
Varenicline

Question 3

Narrow Window drugs (5)

Answer 3

Warfrin
Theophylline
Digoxin
Antiepileptics
Lithium

Question 4

Zero order kinetics

Answer 4

Phenytoin
Ethanol
Aspirin

rate of reaction is constant & independent of substrate concentration

Question 5

Freely excreted (kidney)

drugs

Answer 5

Metformin
Aminoglycosides
Lithium
Vancomycin
β-lactam antibiotics
Digoxin (partially)

Question 6

Slow acetylators

Answer 6

Isoniazid
Procainamide
Hydralazine
Sulfonamides
Dapsone

Question 7

Drug induced Lupus
(& anti-histone AB)

caused by

Answer 7

Hydralazine
Procainamide
Isoniazid
Quinidine

Loopy Professors have High IQ

Question 8

Methaemoglobinuria

drugs causing this

Answer 8

Sulfonamides (Dapsone)
Local anaesthetics
Nitrates

Question 9

Drugs increasing Lithium toxicity

Answer 9

NSAIDs
Thiazides
ACEi (Enalapril)

you’re NAT LITHening

Question 9

SIADH

Answer 9

SSRIs
Carbamazepine
Cyclophosfamide

Question 10

Drug with MAOi activity
(& interaction with serotinin inducing drugs causes seretonin syndrome)

Answer 10

Linezolid

(when combined with: SSRI, SNRI, opioid - tramadol, triptans)

50S (inhibits protein synthesis) - Tx gram(+) MRSA

Question 11

G6PD deficiency - haemolysis inducing drugs

Answer 11

Primaquine, Chloroquine
Sulfatides
Nitrofurantoin, Ciprofloxacin
Ibuprofen, Aspirin

Question 12

drugs affecting microtubules

Answer 12

Mebendazole
Griseofulvin
Colchicine
Vina Alkaloids
Taxanes

Question 13

What drug inhibits secretion of penicillin

Answer 13

Probenecid

Question 14

Can cause idiopathic intracranial hypertension

Answer 14

Tetracyclines
Vitamin A
Danazol

Question 15

Treat SAH vasospasm

Answer 15

Nimodipine

Question 16

QT prolongation

4 drug classes - ‘4A’s’

Answer 16

Antiarrhythmics:
Class IA (quinidine, procainamide), Class III (amiodarone, sotalol)
Antibiotics:
Macrolides (azithromycin), fluoroquinolones (ciprofloxacin)
Antipsychotics:
Haloperidol, ziprasidone
Antidepressants:
TCAs (amitriptyline), SSRIs (citalopram)
Others:
Methadone, ondansetron

Question 17

Bradycardia & AV block

function of what drugs

Answer 17

Beta-blockers (metoprolol)
Calcium channel blockers (verapamil, diltiazem)
Digoxin

Question 18

Theophylline

AE

Answer 18

tachyarrythmia

Adenosine receptor antagonist → increases heart rate (blocks adenosine’s bradycardia effects)

Phosphodiesterase inhibitor → ↑ cAMP → ↑ catecholamine effects

These actions lead to increased cardiac excitability

Question 19

Nitrates are contraindicated with

Answer 19

hypertrophic cardiomyopathy
(nitriates reduce preload -> increase LVOT obstruction)

**PDE-5 inhibitors **
(both vasodilators -> increase hypotensive effects)

Question 19

drugs that displace Digoxin

Answer 19

Verapamil
Amiodarone
Quinidine

Cimetidine (H2 receptor antagonist)

Spironolactone

complete for binding protein
increase digoxin toxicity

(antiarrythmics)

Question 20

procainamide
hydralazine
quinidine
isoniazid

cause what AE

Answer 20

drug induced lupus

Question 21

Cinchonism, Tinnitis

Answer 21

Quinidine

Question 22

sotalol AE

Answer 22

torsades de pointes

Question 23

amiodarone | AE

Answer 23

pulmonary fibrosis hepatotoxicity hypo/hyperthyroidism | *(lipophilic - has I, II, III, IV effects)*

Question 24

hypertrophic pyloric stenosis | drug cause

Answer 24

macrolides | **erythromycin**, clarithromycin, azithromycin ## Footnote **hypokalaemic, hypochloremic metabolic acidosis** 2' to vomiting gastric acid + volume contraction

Question 25

Mycophenolate mofetil 'bug' association

Answer 25

can cause CMV infection

Question 26

Glucocorticoids stopped abruptly

Answer 26

adrenal insufficiency

Question 27

Natalizumab 'virus' association

Answer 27

PML in JC virus patients

Question 28

Sulfa drugs

Answer 28

Sulfonamides Sulfasalazine Probenicid Furosemide Acetazolamide Celecoxib Thiazides Sulfonylureas | 'Scary Sulfa Pharm FACTS'

Question 29

calcium carbonate can chelate with

Answer 29

tetracycline | reduce effectiveness of other drugs

Question 30

serotonin syndrome can occur when sumatriptan is combined with _\_\_

Answer 30

**5-HT agonists** i.e. SSRI, SNRI, MAOi, TCA, busiprone, odansetron, tramadol, linezolid, amphetamines, MDMA

Question 31

drugs relaxing uterus

Answer 31

nifedipine terbutline indomethacin

Question 32

3 assoc with serum sickness

Answer 32

penicillins monoclonal AB hepatitis B

Question 33

(AERD) aspirin-exaccerbated respiratory disease resembles a _\_\_\_ hypersensitivity, but is caused instead by _\_\_\_

Answer 33

T1HS COX inhibition *"pseudoallergic reaction"* | increased conversion to leukotrienes (flushing, bronchial inflammation) ## Footnote T1HS is IgE mediated