Pharmacology Flashcards
NSAIDs with the highest risk for causing PUD (2)
Ketorolac
Piroxicam
100mg of Hydrocortisone is how many mg of Prednisone?
25mg
Dose-limiting toxicity of acyclovir
Nephrotoxicity
Antiviral drug that gets deposited in bones
Foscarnet
Antifungal that inhibits squalene epoxide
Terbinafine
Antifungals that require low gastric pH for absorption (2)
Ketoconazole
Itraconazole
Only clinical indication of griseofulvin
Systemic treatment of dermatophytosis
MOA of griseofulvin
binds to microtubules (like VINca alkaloids)
DOC for neurocysticercosis
Albendazole
DOC for Schistosomiasis
Praziquantel
Steroid preparation of choice for pulse therapy of autoimmune conditions
Methylprednisolone
Antifungal causing gynecomastia, decreased sperm count and libido
Ketoconazole
The CNS toxicity of amantadine and rimantadine is due to alteration of which neurotransmitters?
Dopamine neurotransmitters
Anti-influenza agent administered using an inhaler device
Zanamivir
Antiviral that prevents vertical transmission of HBV when given in the last 4 weeks of gestation
Lamivudine
Antiviral used for topical treatment of condylomata acuminata and actinic keratosis
Imiquimod
Lactic acidosis with hepatic steatosis and fat atrophy with NRTI use
HIV lipodystrophy syndrome
NRTI active against HIV-1 that can cause fatal hypersensitivity syndrome
Abacavir
only HIV protease inhibitor with sulfonamide moiety
Amprenavir / Fos amprenavir
untoward side effect peculiar to Atazanavir
Prolonged PR interval
Increased QT interval
Major adverse effect of bisphosphonates if not ingested properly
Esophageal ulceration
DPP-4 inhibitor with no renal adjustments since it is excreted in the bile
Linagliptin
OHA that decreases postprandial glucose and fasting glucose by inhibition of glucagon release
DPP-4 inhibitors
Antidote for silver poisoning
NSS
Antidote for copper poisoning
Milk
Osteoporotic drug with both antiresorptive and boneforming action
Strontium ranelate
Catalyzes the conversion of plasminogen to plasmin
Streptokinase
Antiarryhthmic with the slowest binding kinetics?
Class IC (flecainide)
Diuretic indicated for acute mountain sickness
Acetazolamide
Digoxin can be used in which type of arrhythmias?
Atrial flutter & fibrillation for rate control
contraindicated in AF in WFW -> may go to VFib
Drugs causing SLE-like adverse effect
Hydralazine
Isoniazid
Procainamide
Methyldopa
Only ACEi with a sulfa group
Captopril
ACEi used to prevent recurrence of stroke
Perindopril
Immunosuppressant that inhibits calcineurin
Ciclosporine
Immunosuppresant that is cleaved to its active metabolite 6-mercaptopurine in vivo
Azathioprine
1st biological drug (monoclonal antibody) approved for the tx of asthma
Omalizumab
Ondansetron is an antagonist of which serotonin receptor?
5-HT3
for n/v prophylaxis
M3 receptor antagonist used in motion sickness
Scopolamine
Antihistamine with anti-EPS effect
Diphenhydramine (ethanolamines)
Give the receptor involved and indication of Buspirone
5-HT1 partial agonist
For anxiety
Give the receptor involved and indication of Sumatriptan
5HT1b/1d partial agonist
for acute migraine
Serotonin receptor antagonist used for pheochromocytoma
Phenoxybenzamine (5HT2)
5HT4 agonist indicated for GERD
Cisapride
Gove the prostanoid of choice to maintain patency of ductus arteriosus
Alprostadil (PGE1)
Give the prostanoid of choice for pulmonary hypertension
Epoprostenol (PGI2)
Antiarryhthmic most notorious for reentry
Class IC
Flecainide
Antiarryhthmic most notorious for causing torsades de pointes
Class III
Sotalol
Ibutilide
Coverage of colistin
Gram negative increased resistant strains
NO gram + and anaerobic coverage
Carbapenem with greatest potential for seizure
Imipenem
Bactericidal protein synthesis inhibitors
Aminoglycosides
Streptogramins (Quinupristin - Dalfopristin)
Bactericidal antibiotic that can’t be used for pneumonia because of inactivation by surfactants
Daptomycin
FQ with anaerobic coverage
Moxifloxacin
Most common adverse effect from prolonged use of linezolid
Reversible thrombocytopenia
Anticonvulsant that is an inhibitor of CYP450
Valproic acid
Anticonvulsants that are inducers of CYP450
Phenobarbital
Phenytoin
Carbamazepine
Lamotrigine
Anticonvulsants that are either CYP450 inducer or inhibitor
Oxcarbazepine
Topiramate
Only serotonin receptor that is ligand-gated
5HT3
Drugs used for alzheimer’s disease
Donepezil
Galantamine
Rivastigmine
Neurotransmitters involved in Parkinson’s disease
Low dopamine
High acetylcholine
Tremors as predominant manifestation of Parkinson’s disease will most likely benefit from this drug
Biperiden (antimuscarinic)
Majority of antiseizure drugs are cleared by hepatic mechanisms, except:
Levetiracetam
Gabapentin
Topiramate