Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

LECOM S3 PBL > pharmacology 37-antivirals > Flashcards

pharmacology 37-antivirals Flashcards

1
Q

what receptor does Maraviroc block

A

CCR5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

how does Enfuviritide block HIV attachment and entry

A

inhibiting gp41-mediated fusion of HIV envelope with the host plasma membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what are the major adverse effects of Maraviroc

A

hepatotoxicity, MI/ischemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what does Enfuviritide mimic

A

HR2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what are the major common adverse effects of Enfuviritide

A

gullain-barre syndrome, 6th nerve palsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

how must enfuviritide be administered

A

parenterally

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is the role of M2 with influenza infection

A

acidifies the interior of the virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what is amantadine used to treat

A

influenza A AND parkinsonism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what is rimantadine used for the treatment of

A

influenza A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what phosphorylates cidofovir

A

cellular enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what ads the first phosphate to acyclovir

A

viral thymidine kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what is the prodrug of acyclovir that has greater oral bioavailability

A

valacyclovir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

when can renal failure occur when using acyclovir or valacyclovir

A

when it is IV administration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is the major adverse effects associated with penciclovir and famciclovir

A

erythema multiform, GI disturbances, headache

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is the prodrug analogue of penciclovir

A

famciclovir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what is ganciclovir and valganciclovir used to treat

A

CMV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what are the major adverse effects of ganciclovir and valganciclovir

A

neutropenia, thrombocytopenia, anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what are the contraindications for ganciclovir and valganciclovir use

A

severe neutropenia and/or thrombocytopenia

19
Q

what is the structure of acyclovir

A

guanine based attached to a broken and incomplete sugar ring

20
Q

what does cidofovir mimic

A

deoxycytidine monophosphate

21
Q

what drug prevents maternal-fetal HIV transmission

A

AZT

22
Q

what is trifluridine used as

A

ophthalmic prepration

23
Q

what anti-HIV -HBV nucleoside and nucleotide analogues are thymidine analogs

A

zidovudine and stavudine

24
Q

what is the dose-limiting adverse effect of zidovudine (AZT)

A

hepatotoxicity

25
Q

what drug used for anti-HIV -HBV nucleoside and nucleotide analogues can cause fatal hypersensitivity

A

abacavir

26
Q

what is the toxicity of anti-HIV -HBV nucleoside and nucleotide analogues mostly due to

A

inhibition of mitochondrial DNA polymerase by drug triphosphate

27
Q

what is a major adverse effect of tenofovir

A

can cause falcon syndrome

28
Q

what is a major adverse effect of adefovir

A

renal toxicity

29
Q

what is the major dose-limiting toxicity of fascarnet

A

renal impairment

30
Q

what does resistance against raltegravir result from

A

point mutations

31
Q

what does raltegravir inhibit

A

inhibits integrase (involved in HIV)

32
Q

what inhibitor of viral integration can cause numbness around mouth and altered taste sensation

A

ritonavir

33
Q

what is the prodrug form of amprenavir that has greater oral bioavailability

A

fosamprenavir

34
Q

what is the action of influenza virus neuraminidase

A

cleaves silica acid from membrane glycoproteins

35
Q

what is zanamivir and oseltamivir used to treat

A

influenza A and B

36
Q

how is zanamivir administered

A

inhaler

37
Q

what does fomivirsen bind to

A

mRNA that encodes iE2 (regulatory protein of CMV)

38
Q

what is the clinical application of fomivirsen

A

CMV retinitis (second-line)

39
Q

what is the contraindication for fomivirsen use

A

IV or intravitreal cidofovir therapy within 2-4 weeks, due to risk for exaggerated ocular inflammation

40
Q

what is ribavirin used for the treatment of

A

respiratory syncytial virus (RSV), HCV (in combination with interferon-alpha)

41
Q

what does ribavirin inhibit

A

inosine monophosphate dehydrogenase, leading to lower cellular GTP levels

42
Q

how is ribavirin administered for treatment of RSV

A

aerosol form

43
Q

what is docosanol used for the treatment of

A

topical treatment for HSV

44
Q

what TLRs does imiquimod interfere with

A

TLR-7 and TLR-8 to boost innate immunity

LECOM S3 PBL (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions