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LECOM S3 PBL > biochemistry 18-cancer > Flashcards

biochemistry 18-cancer Flashcards

1
Q

what is the activation mechanism, location, and disease associated with sis

A

over expression (mechanism), secreted (location), glioma and fibrosarcoma (disease)

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2
Q

what is the activation mechanism, location, and disease associated with into-2

A

amplification (mechanism), secreted (location), breast cancer, bladder cancer, melanoma

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3
Q

what is the activation mechanism, location, and disease associated with hst

A

over expression (mechanism), secreted (location), stomach cancer

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4
Q

what is the activation mechanism, location, and disease associated with erb-b1

A

over expression, cell membrane, squamous cell carcinoma of lung

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5
Q

what is the activation mechanism, location, and disease associated with erb-b2

A

application, cell membrane, and breast/ovarian/lung/stomach cancers

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6
Q

what is the activation mechanism, location, and disease associated with PDGFR

A

translocation, comm membrane, chronic myelomonoytic leukemia

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7
Q

what is the activation mechanism, location, and disease associated with SMO

A

point mutation, cell membrane, basal cell carcinoma

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8
Q

what is the activation mechanism, location, and disease associated with ras

A

point mutation, cytoplasm, multiple cancers (lung, colon, thyroid, pancreas)

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9
Q

what is the activation mechanism, location, and disease associated with akt2

A

amplification, cytoplasm, ovarian carcinoma

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10
Q

what is the activation mechanism, location, and disease associated with raf

A

over expression, cytoplasm, myeloid leukemia

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11
Q

what is the activation mechanism, location, and disease associated with abl

A

translocation, cytoplasm, chronic myeloid leukemia and acute lymphoblastic leukemia

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12
Q

what is the activation mechanism, location, and disease associated with src

A

over expression, cytoplasm, colon carcinoma

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13
Q

what is the activation mechanism, location, and disease associated with RAR-alpha

A

translocation, nucleus, acute promyelocytic leukemia

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14
Q

what is the activation mechanism, location, and disease associated with Hox11

A

translocation, nucleus, acute T-cell leukemia

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15
Q

what is the activation mechanism, location, and disease associated with myc

A

translocation (nucleus and burkitt lymphoma) and amplification (nucleus and neuroblastoma, small cell carcinoma of lung)

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16
Q

what is the activation mechanism, location, and disease associated with fos, jun

A

phosphorylation, nucleus, osteosarcoma, sarcoma

17
Q

what is the activation mechanism, location, and disease associated with Bcl-2

A

translocation, mitochondria, follicular B cell lymphoma

18
Q

what is the activation mechanism, location, and disease associated with cyclin D

A

translocation (nucleus and lymphoma) as well as amplification (breast, liver, esophageal cancers)

19
Q

what is the activation mechanism, location, and disease associated with CDK4

A

nucleus, amplification (glioblastoma and sarcoma) and point mutation (melanoma)

20
Q

what is the location and associated disease of E cadherin

A

cell membrane - stomach cancer

21
Q

what is the location and associated disease of patched

A

cell membrane - basal cell carcinoma

22
Q

what is the location and associated disease of TGF-beta receptor

A

cell membrane- colon cancer

23
Q

what is the location and associated disease of NF-1

A

under cell membrane - neurofibrosarcoma

24
Q

what is the location and associated disease of Smad4/DPC

A

cytoplasm/nucleus- pancreatic and colorectal cancers

25
Q

what is the location and associated disease of WT-1

A

nucleus- wilms tumor

26
Q

what is the location and associated disease of p16 (INK4)

A

nucleus- melanoma, lung, pancreatic cancers

27
Q

what is the location and associated disease of p53

A

nucleus, most cancers

LECOM S3 PBL (10 decks)

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