pharmacology Flashcards

1
Q

• Terbinafine/naftifine MOA

A

squalene epoxidase inhibition,

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2
Q

(block lanosterolergosterol)

A

Ketoconazole

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3
Q

(inhibit 14 a-demethylase) inhibit CYP3A4

A

itraconazole

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4
Q

headache pruritus insomnia nausea

A

PUVA

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5
Q

LP reaction stomatitis PR eruptions

A

gold

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6
Q

acral sclerosis/Raynauds, flagellate hyperpgmentation

A

• bleomycin

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7
Q

RXR receptor 3rd generation retinoid

A

bexarotene

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8
Q

(inducer-COC),

A

Rifampin

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9
Q

grapefruit

A

(CYP3A4 inhibitor)

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10
Q

resorcinol industrial methylated spirit phenol boric acid acetone, magenta,

A

Castellani paint-

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11
Q

↑ flg pdn ↑ keratohyaline granules odland lipid secretion kc ddx i

A

Retinoid-

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12
Q

isotretinoin tetracyctcline hyperT-gemfibrozil,

A

pseudotumor cerebri

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13
Q

chemoprevention,rDEB

A

isotretinoin

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14
Q

isotretinoin T1/2,

A

20H

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15
Q

cranial synostosis premature epiphyseal closure DISH,firbodysplasia ossificans progressiva s aureus

A

retinoid

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16
Q

acute promyelocytic leukemia al trans retinoic acid

A

scrotal ulcers,

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17
Q

hypothyroidism

A

bexarotene

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18
Q

all retinoid h20 soluble except

A

etretinate

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19
Q

all retinoids urine excrete except

A

baxarotene

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20
Q

acitretin conception

A

3 y

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21
Q

retinoid +doxorubicin(\ketoconazole+doxo)=

A

sticky skin

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22
Q

axillae hyperpigmentation

A

• Thiothepa-CA breast

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23
Q

–c55prenol pyrophosphatase inhibit bacterial cell wall synthesis

A

Bacitracin

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24
Q

Renal failure safe antibiotic

A

doxycycline,

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25
Q

• activate calcineurin, ↑K , inhibit APC activation

A

Cya complex

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26
Q

↓fibroblast, ↑glu, ↓ AP1 transcription,intracellular receptor complex, increased neutrophils

A

GC-

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27
Q

MTX - bactrim/dapsone ,

A

hematologic toxicity

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28
Q

methemoglobinemia(rx methylene blue) suppress halide myeloperoxidase system

A

Dapsone-

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29
Q

antimyeloperoxidase ab raised Side effect of

A

Minocycline-

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30
Q

ENL rx

A

-thalidomide,

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31
Q

•peak vulnerable thalidomide,

A

d21-36

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32
Q

/sedation sensory neuropathy,

A

thalidomide,

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33
Q

salicylates tetracyclines phenothiazines NSAID
chloramphenicol, sulfonamides
displacement of plasma proteins

A

↑ MTX

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34
Q

MTX NSAID

A

pancytopenia,

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35
Q

red brown hyperpigmentation

A

Clofazamine r

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36
Q

Liq N2 mustard

A

•- ACD

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37
Q

•– h1+h2 block

A

Doxepin

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38
Q

-jaundice NO reitnopathy

A

Quinacrine

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39
Q

scotoma

A

•chlorquine ,

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40
Q

highest activity CS! –

A

betamethasone

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41
Q

lowest MC CS

A

Methylpred

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42
Q

EOD dose CS does reduce cataracts,

A

F. not

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43
Q

↓adrenal crisis,

A

EOD dose CS

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44
Q

• benzones dibenzoylmethane red veterinary petrolatum parsol, 1789

A

UVA blocker-

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45
Q

ethanol+ acitretin

A

etretinate

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46
Q

oxybenzone

A

UVB+ UVA2 –

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47
Q

hemorrhagic cystitis( mesna)

A

•CPA-

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48
Q

probenecid prolongs t1/2penicillin MOA

A

decr renal tubular secretion,

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49
Q

wegeners granulomatosis rx

A

•CPA-

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50
Q

CPA MOA

A

non cell cycle spec

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51
Q

MMF MOA

A

IMP dehydrogenase noncompetitive inhibit,

52
Q

-potent mutagen , similar colchicine

A

• Podophyllin-kaempherol

53
Q

PABA cinnamates salicylates, padimate A ,

A

UVB blocker

54
Q

how do COC affect free testosterone levels by increase SHBG prodn

A

reduce

55
Q

MMF bind Fe

A

inhibit absorption, deplete de novo guanosine nucleotide

56
Q

finasteride MOA

A

type 2 5alpha reductase

57
Q

trichomegaly diffuse oral hyperpigmented macules streaks in nails

A

zidovudine

58
Q

cya nsaid

A

renal toxic

59
Q

griseofulvin CI

A

Porphyria-

60
Q

headache flushing hypotension anaphylaxis

A

IvIg-

61
Q

all -the ‘vir ?phosphorylation by viral thymidine kinase except

A

CIDOFOVIR

62
Q

flu like symptoms hypertrichiasis

A

• interferon alpha

63
Q

-gray green mid portion permanent teeth

A

minocycline

64
Q

weekly cd4 monitor,

A

im alefaept ,

65
Q

interferon a- HCTZ-

A

lichenoid drug

66
Q

AZA +allopurinol-

A

BM suppression

67
Q

DNA polymerase,

A

acyclovir

68
Q

inhibit RNA polymerase

A

rifampin-

69
Q

cisapride erythromycin

A

fatal ventricular arrythmias

70
Q

cytarabine

A

NEH

71
Q

painful periungual pyogenic granulomas

A

indinavir

72
Q

liposuction lidocaine

A

55mg/kg

73
Q

laxative non pigmenting pseudoephedrine

A

FDE

74
Q

terbinafine verapamil pravastatin

A

drug SCLE ,

75
Q

minocycline hydralazine

A

drug induced LE-

76
Q

acyclovir resistant option

A

forscanet

77
Q

forscanet SE

A

penile erosions,

78
Q

fomivirsen

A

CMV

79
Q

•cetuximab, ACTH

A

Acneiform-

80
Q

• AML- cytarabine

A

red plaques face,

81
Q

vascular leak syndrome

A

denileukin difitox –

82
Q

flammable organophosphate cholinesterase imhibitor

A

Malathion

83
Q

serum sickness reaction

A

Cefaclor

84
Q

( pregnancy C)inhibit T cell trafficking into skin

A

Efalizumab

85
Q

Dimenhydrinate, Cyproheptadine Azeleic acid, Permethrin, Cephalosporins, Lidocaine

A

• preg B

86
Q
  • Penicillin Erythromycin (not estolate- jaundice form due to hepatotoxicity in the mother)•
A

• preg B

87
Q

• Etanercept, alefacept(1xw CD4 T cell) and IV infliximab

A

• preg B

88
Q

50% LFT abnormalities

A

DHS

89
Q

epoxide hydroxylase deficiency

A

DHS

90
Q

onycholysis-

A

tetracyclines•`` -doxy tetra demeclocycline)

91
Q

which tetracycline NOT phototoxic

A

```minocycline

92
Q

tachyphylaxis

A

hydroquinone cream-

93
Q

voriconazole side effect

A

• - altered vision

94
Q

↑ CMZ

A

EMycin

95
Q

• abacavir rechallenge

A

fatal

96
Q

K iodide iodine

A

wolff chaikoff effect TFT

97
Q

FDA NHL

A

rituximab

98
Q

•chloramphenicol,

A

RMSF-

99
Q

cetirizine a metabolite of

A

hydroxyzin–

100
Q

AZA allopurinol panycytopenia why?

A

TPMT low

101
Q

• acquired brachial dyschromatosis

A

ACE inhibitors

102
Q

dilantin hypersensitivity- alternative

A

valproic

103
Q

inhibit fumarate reductase, ,

A

thiabendazole-

104
Q

poikiloderma anemia acral erythema leg ulcers,

A

hydroxyurea

105
Q

ampicillin azithro cefazolin mercury

A

agep-

106
Q

EMPD treatment

A

imiquimod-

107
Q

incr IL10, decr IL2 photosensitivity inhibit nfkb

A

calciprotriene-,

108
Q

valacyclovir Aids transplant

A

TTP

109
Q

suppressor t cell acitvity antiandrogen reduces methemoglobin,,

A

cimetidine-

110
Q

painful symmetrical erythema paresthesia, ,

A

sorafenib

111
Q

SPF

A

2mg /cm2,

112
Q

If an adequate response has
not been achieved after? months of treatment at a dose
of 5 mg/kg/day, cyclosporine should be withdrawn

A

3

113
Q

you want to start cyclosporine 5 mg/kg/day. mother wants the child to be started on a lower dose (2.5 mg/kg/day). She asks if this is a reasonable
treatment option.

A

Yes, although the higher dose will result in more
rapid improvement, current studies suggest that in
6 to 8 weeks, the decrease in severity will be equal
regardless of the initial dose

114
Q

Which of the following lipid lowering agents may

impair renal function during cyclosporine treatment

A

Fenofibrate

115
Q

the most frequent class of antiretrovirals to cause morbilliform exanthems

A

Nonnucleoside reverse transcriptase inhibitors

116
Q

Which of the following IRAEs associ-ated with ipilimumab is potentially irreversible?

A

pituitary dysfunction (hyophysitis)
adrenal
suppression.

117
Q

Ipilumumab Which of the following has been shown to be associated with increased survival?

A

The development of stage 3 and 4 IRAEs

118
Q

worrisome potential toxicity ofsodium thiosulfate?

A

An anion gap resulting in metabolic acidosisdue to the presence of thiosulfuric acid

119
Q

Minocycline-induced hyperpigmentation blue-black discoloration in areas of inflammation or scarring type? result of?

A

type I , result of hemosiderin deposition stain for iron and not melanin.

120
Q

Minocycline-induced hyperpigmentation on normal, unaffected skin as a blue-gray discoloration, typically shins and other extensor surfaces. result of?

A

type II, result of? both hemosiderin and melanin

121
Q

Minocycline-induced hyperpigmentation diffuse muddy browncolor imparted to sun-exposed areas, which may correspond to a low-grade photosensitivity reaction. Result of?

A

type 3, Type III increased amounts of melanin only and are negative for iron.

122
Q

Fe stain by

A

Perl

123
Q

Melanin stain by

A

Fontana masson

124
Q

? Chemo agent has been associated with photosensitivity, rash, erythema multiforme, and alopecia

A

Vinblastine

125
Q

Panitumumab and other epidermal growth factor receptor (EGFR) inhibitors, such as cetuximab, gefitinib, and erlotinib—may cause

A

Trichomegaly growth cycle of the hair follicle, leading to abnormal hair growth.1

126
Q

most frequently observed skin reactions to EGFR inhibitor

A

Acneiform rash—without the presence of comedones, are the most frequently observed skin reactions to EGFR inhibitors. It occurs approximately in 82% of cases.