pharmacology Flashcards
1
Q
• Terbinafine/naftifine MOA
A
squalene epoxidase inhibition,
2
Q
(block lanosterolergosterol)
A
Ketoconazole
3
Q
(inhibit 14 a-demethylase) inhibit CYP3A4
A
itraconazole
4
Q
headache pruritus insomnia nausea
A
PUVA
5
Q
LP reaction stomatitis PR eruptions
A
gold
6
Q
acral sclerosis/Raynauds, flagellate hyperpgmentation
A
• bleomycin
7
Q
RXR receptor 3rd generation retinoid
A
bexarotene
8
Q
(inducer-COC),
A
Rifampin
9
Q
grapefruit
A
(CYP3A4 inhibitor)
10
Q
resorcinol industrial methylated spirit phenol boric acid acetone, magenta,
A
Castellani paint-
11
Q
↑ flg pdn ↑ keratohyaline granules odland lipid secretion kc ddx i
A
Retinoid-
12
Q
isotretinoin tetracyctcline hyperT-gemfibrozil,
A
pseudotumor cerebri
13
Q
chemoprevention,rDEB
A
isotretinoin
14
Q
isotretinoin T1/2,
A
20H
15
Q
cranial synostosis premature epiphyseal closure DISH,firbodysplasia ossificans progressiva s aureus
A
retinoid
16
Q
acute promyelocytic leukemia al trans retinoic acid
A
scrotal ulcers,
17
Q
hypothyroidism
A
bexarotene
18
Q
all retinoid h20 soluble except
A
etretinate
19
Q
all retinoids urine excrete except
A
baxarotene
20
Q
acitretin conception
A
3 y
21
Q
retinoid +doxorubicin(\ketoconazole+doxo)=
A
sticky skin
22
Q
axillae hyperpigmentation
A
• Thiothepa-CA breast
23
Q
–c55prenol pyrophosphatase inhibit bacterial cell wall synthesis
A
Bacitracin
24
Q
Renal failure safe antibiotic
A
doxycycline,
25
• activate calcineurin, ↑K , inhibit APC activation
Cya complex
26
↓fibroblast, ↑glu, ↓ AP1 transcription,intracellular receptor complex, increased neutrophils
GC-
27
MTX - bactrim/dapsone ,
hematologic toxicity
28
methemoglobinemia(rx methylene blue) suppress halide myeloperoxidase system
Dapsone-
29
antimyeloperoxidase ab raised Side effect of
Minocycline-
30
ENL rx
-thalidomide,
31
•peak vulnerable thalidomide,
d21-36
32
/sedation sensory neuropathy,
thalidomide,
33
salicylates tetracyclines phenothiazines NSAID
chloramphenicol, sulfonamides
displacement of plasma proteins
↑ MTX
34
MTX NSAID
pancytopenia,
35
red brown hyperpigmentation
Clofazamine r
36
Liq N2 mustard
•- ACD
37
•– h1+h2 block
Doxepin
38
-jaundice NO reitnopathy
Quinacrine
39
scotoma
•chlorquine ,
40
highest activity CS! –
betamethasone
41
lowest MC CS
Methylpred
42
EOD dose CS does reduce cataracts,
F. not
43
↓adrenal crisis,
EOD dose CS
44
• benzones dibenzoylmethane red veterinary petrolatum parsol, 1789
UVA blocker-
45
ethanol+ acitretin
etretinate
46
oxybenzone
UVB+ UVA2 –
47
hemorrhagic cystitis( mesna)
•CPA-
48
probenecid prolongs t1/2penicillin MOA
decr renal tubular secretion,
49
wegeners granulomatosis rx
•CPA-
50
CPA MOA
non cell cycle spec
51
MMF MOA
IMP dehydrogenase noncompetitive inhibit,
52
-potent mutagen , similar colchicine
• Podophyllin-kaempherol
53
PABA cinnamates salicylates, padimate A ,
UVB blocker
54
how do COC affect free testosterone levels by increase SHBG prodn
reduce
55
MMF bind Fe
inhibit absorption, deplete de novo guanosine nucleotide
56
finasteride MOA
type 2 5alpha reductase
57
trichomegaly diffuse oral hyperpigmented macules streaks in nails
zidovudine
58
cya nsaid
renal toxic
59
griseofulvin CI
Porphyria-
60
headache flushing hypotension anaphylaxis
IvIg-
61
all -the ‘vir ?phosphorylation by viral thymidine kinase except
CIDOFOVIR
62
flu like symptoms hypertrichiasis
• interferon alpha
63
-gray green mid portion permanent teeth
minocycline
64
weekly cd4 monitor,
im alefaept ,
65
interferon a- HCTZ-
lichenoid drug
66
AZA +allopurinol-
BM suppression
67
DNA polymerase,
acyclovir
68
inhibit RNA polymerase
rifampin-
69
cisapride erythromycin
fatal ventricular arrythmias
70
cytarabine
NEH
71
painful periungual pyogenic granulomas
indinavir
72
liposuction lidocaine
55mg/kg
73
laxative non pigmenting pseudoephedrine
FDE
74
terbinafine verapamil pravastatin
drug SCLE ,
75
minocycline hydralazine
drug induced LE-
76
acyclovir resistant option
forscanet
77
forscanet SE
penile erosions,
78
fomivirsen
CMV
79
•cetuximab, ACTH
Acneiform-
80
• AML- cytarabine
red plaques face,
81
vascular leak syndrome
denileukin difitox –
82
flammable organophosphate cholinesterase imhibitor
Malathion
83
serum sickness reaction
Cefaclor
84
( pregnancy C)inhibit T cell trafficking into skin
Efalizumab
85
Dimenhydrinate, Cyproheptadine Azeleic acid, Permethrin, Cephalosporins, Lidocaine
• preg B
86
- Penicillin Erythromycin (not estolate- jaundice form due to hepatotoxicity in the mother)•
• preg B
87
• Etanercept, alefacept(1xw CD4 T cell) and IV infliximab
• preg B
88
50% LFT abnormalities
DHS
89
epoxide hydroxylase deficiency
DHS
90
onycholysis-
tetracyclines•`` -doxy tetra demeclocycline)
91
which tetracycline NOT phototoxic
```minocycline
92
tachyphylaxis
hydroquinone cream-
93
voriconazole side effect
• - altered vision
94
↑ CMZ
EMycin
95
• abacavir rechallenge
fatal
96
K iodide iodine
wolff chaikoff effect TFT
97
FDA NHL
rituximab
98
•chloramphenicol,
RMSF-
99
cetirizine a metabolite of
hydroxyzin--
100
AZA allopurinol panycytopenia why?
TPMT low
101
• acquired brachial dyschromatosis
| •
ACE inhibitors
102
dilantin hypersensitivity- alternative
valproic
103
inhibit fumarate reductase, ,
thiabendazole-
104
poikiloderma anemia acral erythema leg ulcers,
hydroxyurea
105
ampicillin azithro cefazolin mercury
agep-
106
EMPD treatment
imiquimod-
107
incr IL10, decr IL2 photosensitivity inhibit nfkb
calciprotriene-,
108
valacyclovir Aids transplant
TTP
109
suppressor t cell acitvity antiandrogen reduces methemoglobin,,
cimetidine-
110
painful symmetrical erythema paresthesia, ,
sorafenib
111
SPF
2mg /cm2,
112
If an adequate response has
not been achieved after? months of treatment at a dose
of 5 mg/kg/day, cyclosporine should be withdrawn
3
113
you want to start cyclosporine 5 mg/kg/day. mother wants the child to be started on a lower dose (2.5 mg/kg/day). She asks if this is a reasonable
treatment option.
Yes, although the higher dose will result in more
rapid improvement, current studies suggest that in
6 to 8 weeks, the decrease in severity will be equal
regardless of the initial dose
114
Which of the following lipid lowering agents may
| impair renal function during cyclosporine treatment
Fenofibrate
115
the most frequent class of antiretrovirals to cause morbilliform exanthems
Nonnucleoside reverse transcriptase inhibitors
116
Which of the following IRAEs associ-ated with ipilimumab is potentially irreversible?
pituitary dysfunction (hyophysitis)
adrenal
suppression.
117
Ipilumumab Which of the following has been shown to be associated with increased survival?
The development of stage 3 and 4 IRAEs
118
worrisome potential toxicity ofsodium thiosulfate?
An anion gap resulting in metabolic acidosisdue to the presence of thiosulfuric acid
119
Minocycline-induced hyperpigmentation blue-black discoloration in areas of inflammation or scarring type? result of?
type I , result of hemosiderin deposition stain for iron and not melanin.
120
Minocycline-induced hyperpigmentation on normal, unaffected skin as a blue-gray discoloration, typically shins and other extensor surfaces. result of?
type II, result of? both hemosiderin and melanin
121
Minocycline-induced hyperpigmentation diffuse muddy browncolor imparted to sun-exposed areas, which may correspond to a low-grade photosensitivity reaction. Result of?
type 3, Type III increased amounts of melanin only and are negative for iron.
122
Fe stain by
Perl
123
Melanin stain by
Fontana masson
124
? Chemo agent has been associated with photosensitivity, rash, erythema multiforme, and alopecia
Vinblastine
125
Panitumumab and other epidermal growth factor receptor (EGFR) inhibitors, such as cetuximab, gefitinib, and erlotinib—may cause
Trichomegaly growth cycle of the hair follicle, leading to abnormal hair growth.1
126
most frequently observed skin reactions to EGFR inhibitor
Acneiform rash—without the presence of comedones, are the most frequently observed skin reactions to EGFR inhibitors. It occurs approximately in 82% of cases.
