pharmacology Flashcards
• Terbinafine/naftifine MOA
squalene epoxidase inhibition,
(block lanosterolergosterol)
Ketoconazole
(inhibit 14 a-demethylase) inhibit CYP3A4
itraconazole
headache pruritus insomnia nausea
PUVA
LP reaction stomatitis PR eruptions
gold
acral sclerosis/Raynauds, flagellate hyperpgmentation
• bleomycin
RXR receptor 3rd generation retinoid
bexarotene
(inducer-COC),
Rifampin
grapefruit
(CYP3A4 inhibitor)
resorcinol industrial methylated spirit phenol boric acid acetone, magenta,
Castellani paint-
↑ flg pdn ↑ keratohyaline granules odland lipid secretion kc ddx i
Retinoid-
isotretinoin tetracyctcline hyperT-gemfibrozil,
pseudotumor cerebri
chemoprevention,rDEB
isotretinoin
isotretinoin T1/2,
20H
cranial synostosis premature epiphyseal closure DISH,firbodysplasia ossificans progressiva s aureus
retinoid
acute promyelocytic leukemia al trans retinoic acid
scrotal ulcers,
hypothyroidism
bexarotene
all retinoid h20 soluble except
etretinate
all retinoids urine excrete except
baxarotene
acitretin conception
3 y
retinoid +doxorubicin(\ketoconazole+doxo)=
sticky skin
axillae hyperpigmentation
• Thiothepa-CA breast
–c55prenol pyrophosphatase inhibit bacterial cell wall synthesis
Bacitracin
Renal failure safe antibiotic
doxycycline,
• activate calcineurin, ↑K , inhibit APC activation
Cya complex
↓fibroblast, ↑glu, ↓ AP1 transcription,intracellular receptor complex, increased neutrophils
GC-
MTX - bactrim/dapsone ,
hematologic toxicity
methemoglobinemia(rx methylene blue) suppress halide myeloperoxidase system
Dapsone-
antimyeloperoxidase ab raised Side effect of
Minocycline-
ENL rx
-thalidomide,
•peak vulnerable thalidomide,
d21-36
/sedation sensory neuropathy,
thalidomide,
salicylates tetracyclines phenothiazines NSAID
chloramphenicol, sulfonamides
displacement of plasma proteins
↑ MTX
MTX NSAID
pancytopenia,
red brown hyperpigmentation
Clofazamine r
Liq N2 mustard
•- ACD
•– h1+h2 block
Doxepin
-jaundice NO reitnopathy
Quinacrine
scotoma
•chlorquine ,
highest activity CS! –
betamethasone
lowest MC CS
Methylpred
EOD dose CS does reduce cataracts,
F. not
↓adrenal crisis,
EOD dose CS
• benzones dibenzoylmethane red veterinary petrolatum parsol, 1789
UVA blocker-
ethanol+ acitretin
etretinate
oxybenzone
UVB+ UVA2 –
hemorrhagic cystitis( mesna)
•CPA-
probenecid prolongs t1/2penicillin MOA
decr renal tubular secretion,
wegeners granulomatosis rx
•CPA-
CPA MOA
non cell cycle spec