gen derm Flashcards
1
Q
Sneddon wlkinson Rx
A
NBUVB
2
Q
Sneddon wlkinson Association with
A
IgA monoclonal
gammopathy
3
Q
Drug-induced DMS implicated drugs include
A
hydroxyurea, penicillamine, statins, quinidine, and phenylbutazone)
4
Q
Foregut carcinoid tumor releases
A
serotonin
5
Q
what tumor causes itense flushing peptic ulcer lacrimation
A
Foregut carcinoid tumor
6
Q
ACD PPD X react with
A
sulfa drug
7
Q
neutrophilic dermatoses e.g. PG association with
A
IgA gammopathy
8
Q
chronic AD cytokine
A
IFNy,
9
Q
anterior subcapsular cataracts keratoconus P alba
A
AD
10
Q
K6/k16 expression upregulated in
A
psoriatic plaque,
11
Q
low c2/4 occurs in
A
Sle, acquired c1 estrase deficient-
12
Q
beefy red tongue folate deficiency associated with?
A
Celiac desease
13
Q
lithium pred phenytoin isoniazid cause
A
acneiform-
14
Q
primary cutaneous amyloidosis protein
A
keratin
15
Q
earlier onset more severe psoriasis
A
HLA B17
16
Q
anti centromere assoc w
A
Crest-
17
Q
antifodrin 93% specific for
A
sjogren-
18
Q
hemorrhagic onycholysis caused by which drug?
A
taxanes
19
Q
Psoriatic arthritis HLA link
A
HLAB 27
20
Q
Minocycline discoloration shows blue within what cells?
A
macrophages
21
Q
sneddon wilkinson configuration
A
annular serpinginous
22
Q
Partial lipodystrophy serum shows ?
A
decreased c3,
23
Q
most definitive associated HLA type with psoriasis, relative risk 9-15 times normal
A
HLA cw6
24
Q
pits-nail, location abn
A
matrix- ,
25
pseudoparalysis parrot observed in
congential syphilis
26
unilateral or ipsilateral pectoralis major aplasia, ipsilateral limb shortening, ipsilateral foot enlargement, spina bifida, scoliosis, pectus carinatum, localized lipoatrophy,congenital adrenal hyperplasia\ polythelia and accessory scrotum,
Becker nevus
27
Fibrodysplasia ossificans progressiva endochrondral,
Osteoma cutis
28
What condition avoid aspirin
CIU
29
dermatomyosisits location muscle biopsy,
triceps
30
behcets ASSOCIATED hla
hlab 51
31
GA subcutaneous commoner in which age group
children
32
krazy glue ACD
ethyl cyanoacrylate
33
tosylonamide formaldehyde causes
eyelid dermatitis
34
dermatomyosisits cytokine
TNFa,
35
anti Mi-2 significance
favorable prognosis
36
juvenile dermatomyosisits cytokine
↑ thrombospondin
37
Spindle cell lipoma location
posterior shoulder
38
A.A transport defect, AR, pellagra like, intermittent ataxia
hartnup disease
39
phyrnoderma
vitamin A deficiency~
40
diarrhea dementia photosensitive dermatitis
Pellagra-niacin def
41
INH, AZA, 5FU,
Pellagra-
42
• Malignant atrophic papulosis Degos disease
| mortality
myocardial ischemia
43
large vessel –
takayasu arteritis,
44
Hydralazine HLA DR4, peicillamine cause
drug induced lupus-
45
14%, with slow acetylators (HLA-DR4)
| more prone
Hydralazine induced lupus
46
What drug induces native SLE disease, with anti-dsDNA Ab’s
Penicillamine
47
Vitamin D deficiency- hair
alopecia,
48
Xanthoma disminatum to check gland?
pituitary gland, DI
49
Reiter- chronic deforming arthritis in %
20 %
50
schnitzlers syndrome aw
sensorimotor neuropathy
51
IgG lamda monoclonal gammotpathy dm strep infection
scleremyxedema-
52
Pulmonary Fibrosis raynauds ssystemic sclerosis - linear morphea,,- ,
bleomycin-
53
pitted keratolysis organism
Micrococcus sedentaris
54
Post transplant ctcl-renal stransplant
cyclosporine
55
ACE - sensitivity 60, specificity 80
Sarcoidosis
56
sneddon syndrome aw
venous thrombosis
57
debride cooling, effect dressing
Dhdrogel-
58
50s subunit
, emycin
59
inhibit RNA dependent protein synthesis bind 30s ribosomal
azithromycin
60
Long-term morbidity from kidney disease, which is predicted by the spread of purpura to
the upper trunk
HSP
61
DH and lymphoma risk
NHL
62
30% of patients with SLe
anti-U1RNP
63
Majority of patients with positive U1RNP have
SLE rather than MCTD
64
atypical beaded papule nasal rim
Lofgren syndrome
65
partial lipodystrophy mutation LMNA gene
dunnigan variant
66
shoulder blade rippled hyperpigmented
sipple syndrome
67
myotonic dystrophy aw
pilomatricomas
68
MAGIC syndrome
relapsing polychondritis
69
Erythema gyratum repens underlying
lung cancer
70
ANA-negative sle → determined often on animal substrates, yet later found to be positive
on human cells, or if patient only makes antibodies to ?
ssdna (not detected by most tests)
71
DMS hi-risk pulmonary dz,
anti Jo 1
72
nevus achromicus congenital melanopenic ?extracutaneous assoc
no extracutaneous assoc
73
safe anestehtic in mastocytosis
propofol
74
Useful in testing ANA negative patients with clinical manifestations of sle or scle
ro la
75
Neonatal lupus hematologic abn
thrombocytopenia,
76
Light based acne therapy targets
Coproporphyrin 111
77
Which Cytokine marker of psoriasis disease severity
IL22
78
What cytokine in psoriasis stimulates Th1 cells
IL12
79
What cytokine in psoriasis stimulates Th17 cells
IL23
80
Onycholysis splinter hemorrhage and oil spots affects which part of nail
Nail bed
81
Pitting leukonychia, onychodystrophy affects which part of nail
Nail matrix N.B onychodystrophy- bed and matrix
82
Calcipotriene inactivated by
Salicylic acid
83
effect of rifampin on OCP efficacy
reduces
84
azelaic acid MOA acne
ihibit tyrosinase, PIPA
85
psorriasis early onset HLA
B17
86
psorriasis arthritis HLA
HLA B27
87
PAPA syndrome mutations
AD, PSTPIP1, CD2BP1
88
defective protein in FMF
pyrin
89
which biologic CI in CHF, cause drug induced SLE
infliximab
90
biologics which cause drug induced SLE
infliximab, etanercept
91
cause of infantile acne
elevated LH levels
92
Saroidosis lab abormality
Hypercalcemia
93
Commonest systemic sclerosis systemi finding
Esophageal dysfunction
94
ACE ihibitors cause angioedea via stimulation of
Bradykinin
95
```
Drug reaction with eosinophilia and
systemic symptoms (DRESS) syndrome is
a potentially life-threatening adverse
drug-induced reaction, with an
estimated mortality of
```
10%.
96
most frequently reported causative agents of DRESS
| syndrome
carbamazepine
97
most frequently affected visceral organ of DRESS
| syndrome
liver
98
AGEP’s 5% mortality rate is most often
| related to
secondary infection
99
patch test-ing shouldbe performed when after DRESS
2 to 6 months after recoveryfrom the symptoms.
100
recommended to per-form LTT when after the onset of DRESSsyndrome
5 to 8 weeks after the onset of DRESSsyndrome
101
useful diagnostic imaging techniques
| for assessing Cardiac Sarcoidosis
Positron emission tomographic and gadolinium-enhanced cardiac magnetic resonance imaging scans
102
Eosinophils do reliably distinguish histologic findings of
| drug exanthem from acute graft-versus-host disease
not
103
In CGVHD, when is systemic therapy warranted?
Sclerotic skin involvement, particularly fascial disease, should prompt aggressive treatment before the development of
Skin contractures functional disability
104
Calcification can be observed in ?panniculitis
Calcification can be observed in pancreatic pannicultis and lupus panniculitis
105
Painful calcification on the finger has also been effectively treated
with
surgical debridement.
106
Iodine use and iodine-containing diets (such asshellfish) have been reported to induce flares of
DH
107
serologic tests that may confirm the diagnosis of dermatitis herpetiformis and be used to monitor disease activity
Tissue and epidermal transglutaminases
108
DH likelihood of a family member having a similar condition?
18%
109
? Raynaud phenomenon does not have nail-fold capillary changes, usually has an onset during the teenage years, and does not cause necrosis or gangrene of the digits
Primary
110
Extracutaneous manifestations in morphea are ? rare
Not
111
Morphea
| The most common extracutanous manifestation is
arthralgia
112
Morphea Central nervous systemfibrosis is most common in those children with
head and neck involvenent
113
Children with head and neck morphea
| should have regular
ophthalmologic examination monitor
| for Asymptomaticinvolvement that may lead to irreversible damage
114
The outcome
| measure best suited for morphea is:
```
Localized Scleroderma Cutaneous
Assessment Tool is a promising recently
validated skin scoring tool that allows
differentiation between activity and
damage, is sensitive to change, and
requires no additional equipment.
```
115
two therapies for
morphea with the most
clinical data
Methotrexate in combination
with systemic steroids
and ultraviolet A1
light phototherapy
116
morphea treatment Narrowband ultraviolet B light phototherapy
is as effective as low dose ultraviolet
A1 phototherapy
T
117
Topical tacrolimus is an effective treatment
| for active plaque morphea
t
118
plaque morphea combination of calcipotriol in combination with betamethasone dipropionate is
supported by level
IIB evidence
119
type of arthritis Morning stiffness(min)>60, better with activity
PsA, RA
120
```
Reactive arthritis (ReA) is distinguished from
psoriatic arthritis (PsA) by its
```
- acute onset arthritis and enthesitis,
| - additive involvement of new joints over days
121
Which of the following imaging findings is unique to psoriatic arthritis
Osteopenia
122
Osteophyte formation, joint space narrowing,
| and the absence of erosions distinguish
OA from PsA on plain radiographic film
123
CCP Ab Present in ?
RA
124
Flame figures may be seen in which of thefollowing conditions?
a. Bullous pemphigoid
b. Eczema
c. Arthropod bites
d. Dermatophyte infections
All
125
average age of onset of drug-induced SCLE is ?than that of idiopathic SCLE.
older (59.5 years)
126
Associated disease with Pemphigoid gestationis
Graves disease is seen in about 10% of patients with PG
127
calciphylaxis calcium phosphate product level
elevated calcium phosphate product (Ca 3 P) of[70 mg2/dL2 is associated with calciphylaxis, most patients with calciphylaxis have anormal product.
128
Which nerve is responsible for sensory inner-vation of the most commonly affected site? In TTS?
b. Maxillary branch of the trigeminal nerve
129
treatment of choice for EED is
dapsone
130
Schnitzler syndrome best treatment
Anakinra, an IL-1 re-ceptor antagonist, appears to be a promising agent,
131
Schnitzler syndrome Cx
Waldenstro¨m macroglobulinemia
132
Vanco RMS cause
Degranulation of mast cells independently ofimmunoglobulin E or complemen
133
Type 6 PRP
HIV associated, follicular spines, Hidradenitis suppurativa, acne conglobata
134
PRP subtype familial cases associated with ichthyosiform scaling, sclerodermatous changes of the hands and feet.
Type V,atypical juvenile PRP,
135
most common juvenile variant, PRP.
Juvenile focal—or type IV—PRP representsthe most common juvenile variant, and the secondmost common variant overall, accounting for ap-proximately 25% of all cases.
136
mangos (Mangifera indica) belong to the ?-containing plant family Anacardiaceae, and sensitized patients can develop a contact dermatitis similar to that of ?.
Urushiol—Correct. Like poison ivy, mangos (Mangifera indica) belong to the urushiol-containing plant family Anacardiaceae, and sensitized patients can develop a contact dermatitis similar to that of poison ivy contact dermatitis.The resorcinol in mango cross-reacts in patch tests with the catechols of poison ivy.
137
Japanese lacquer tree, cashew nut tree, ginkgo fruit pulp, the marking nut tree of India, and the Brazilian pepper tree. Mango, poison ivy
sources of urushiol
138
valuable therapeutic option for the treatment of refractory cutaneous cGvHD;
ECP
139
Treatment for cutaneous sarcoidosis first-line therapy for localized scar sarcoidosis.
Topical or intralesional corticosteroid
140
production of colored sweat that contains water-soluble pigments. The consumption of drugs, such as quinine, has been reported to be causative.
Eccrine chromhidrosis—
141
What steroid-sparing agent is often used with oral corticosteroids to treat pemphigus vegetans?
Acitretin—Correct. The use of acitretin and steroids has been reported to be effective in the treatment of large verrucous lesions of PV.
142
treatments is most appropriate for this persistent, pruritic rash?grovers
Pramoxine lotion twice daily and as needed for pruritus
143
Id reaction cytokine
interleukin-1
144
is a sudden,generalized eczematous eruption which occurs dis-tant fromthe primary condition. It is commonly seenin stasis dermatitis, contact dermatitis, and infectionsfrom bacteria and dermatophytes, pediculosis, molluscum contagiosum, my-cobacterium infection, and radiation therapy.
Id reaction, or autoeczematization,
145
Renbok phenomenon, or inverse Koebner phenomenon,
was first described in 1991 by Happle in an individual afflicted with two skin diseases (alopecia areata and psoriasis). It refers to normal hair growth in psoriatic plaques surrounded by hair loss caused by alopecia areata.
146
exhibit apple jelly color on diascopy,
Lupus vulgaris, sarcoidosis
147
?xanthomas seen in familial hypercholesterolemia.
familial hypercholesterolemia.
148
? xanthomas can occur with hypertriglyceridemia.
hypertriglyceridemia.
| TC, ET,
149
? xanthomas can be seen with dysbetalipoproteinemia.
Palmar xanthomas can be seen with dysbetalipoproteinemia.
| Terms &Conditions, Extra Terrestrial, Play Bad
150
?xanthomas, which are protuberant nodules over the knees and elbows, also occur in familial hypercholesterolemia
Tuberous xanthomas, which are protuberant nodules over the knees and elbows, also occur in familial hypercholesterolemia but were not present in this patient.
Mnemonic
145 Extra- Terrestials ( eruptive, hypertriglyceridemia)
Play Bad ( palmar, dysBetalipoproteimemia) so u better agree to
Terms & Conditions i.e. Bad ( tuberous,tendinous hypercholesterolemia, also dysBetaliproteinemia ),
151
following has (have) been associated withsyringomas
a. Marfan syndrome
b. Down’s syndrome
c. atrophoderma vermiculata
d. EhlerseDanlos syndrome
152
Secondary cold urticaria has in some patients been associated with
hepatitis B or C infection, lymphoproliferativedisease, or infectious mononucleosis.
153
PLEVA, vs PLC histo
PLEVA, apoptotic and necrotic keratinocytes, neutrophils, and erythrocytes epidermotropic infiltrate of CD8+ T lymphocytes. Parakeratosis vs PLC CD4+
154
Antibodies associated with MCTD
U1RNP, hnRNP2
155
digital skin color changes with Raynaud’sphenomenon naturally progress in which of thefollowing orders?
d. white then blue then red
156
Raynauds ismost often seen in association with
systemic sclero-sis.
157
Pellagra caused by
niacin , comes fromsynthesis fromtheamino acid tryptophan. This process requires vita-mins B2 and B6 (riboflavin and pyridoxine
158
a. malabsorptive disorders
b. chronic alcoholism
d. Hartnup’s disease
e. carcinoid syndrome
Pellagrous
159
trigeminal trophic syndrome best treatment
The best treatment is use of an occlu-sive dressing or prosthesis, which prevents furthermanipulation.
160
Axillary parakeratosis defect
in processing of profilaggrin to filaggrin
161
Sarcoidosis is associated
| with
CD4+ Th1 T-helper cells
162
Sarcoidosis has been associated with the fol-lowing
lymphoproliferative
disorders
chronic myelogenous leukemia
b. hairy cell leukemia
d. Hodgkin’s lymphoma
e. non-Hodgkin’s lymphoma
163
Sarcoidosis has been associated with the fol-lowing solid tumors
a. testicular cancer
c. melanoma
d. lung cancer
e. carcinoid tumors
164
Sarcoidosis is associated with HLA-
Sarcoidosis is associated with
a. HLA-1
b. HLA-B8
c. HLA-DR3
165
Sarcoidosis has been associated the followingautoimmune disorders
a. vitiligo
c. autoimmune thyroiditis
d. Sjogren’s syndrome
e. systemic lupus erythematosus
166
Id reaction cytokines
interleukins 1 and 6 and tumor necrosis factor a
