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AAD ETAS > gen derm > Flashcards

gen derm Flashcards

1
Q

Sneddon wlkinson Rx

A

NBUVB

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2
Q

Sneddon wlkinson Association with

A

IgA monoclonal

gammopathy

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3
Q

Drug-induced DMS implicated drugs include

A

hydroxyurea, penicillamine, statins, quinidine, and phenylbutazone)

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4
Q

Foregut carcinoid tumor releases

A

serotonin

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5
Q

what tumor causes itense flushing peptic ulcer lacrimation

A

Foregut carcinoid tumor

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6
Q

ACD PPD X react with

A

sulfa drug

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7
Q

neutrophilic dermatoses e.g. PG association with

A

IgA gammopathy

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8
Q

chronic AD cytokine

A

IFNy,

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9
Q

anterior subcapsular cataracts keratoconus P alba

A

AD

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10
Q

K6/k16 expression upregulated in

A

psoriatic plaque,

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11
Q

low c2/4 occurs in

A

Sle, acquired c1 estrase deficient-

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12
Q

beefy red tongue folate deficiency associated with?

A

Celiac desease

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13
Q

lithium pred phenytoin isoniazid cause

A

acneiform-

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14
Q

primary cutaneous amyloidosis protein

A

keratin

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15
Q

earlier onset more severe psoriasis

A

HLA B17

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16
Q

anti centromere assoc w

A

Crest-

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17
Q

antifodrin 93% specific for

A

sjogren-

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18
Q

hemorrhagic onycholysis caused by which drug?

A

taxanes

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19
Q

Psoriatic arthritis HLA link

A

HLAB 27

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20
Q

Minocycline discoloration shows blue within what cells?

A

macrophages

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21
Q

sneddon wilkinson configuration

A

annular serpinginous

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22
Q

Partial lipodystrophy serum shows ?

A

decreased c3,

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23
Q

most definitive associated HLA type with psoriasis, relative risk 9-15 times normal

A

HLA cw6

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24
Q

pits-nail, location abn

A

matrix- ,

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25
Q

pseudoparalysis parrot observed in

A

congential syphilis

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26
Q

unilateral or ipsilateral pectoralis major aplasia, ipsilateral limb shortening, ipsilateral foot enlargement, spina bifida, scoliosis, pectus carinatum, localized lipoatrophy,congenital adrenal hyperplasia\ polythelia and accessory scrotum,

A

Becker nevus

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27
Q

Fibrodysplasia ossificans progressiva endochrondral,

A

Osteoma cutis

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28
Q

What condition avoid aspirin

A

CIU

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29
Q

dermatomyosisits location muscle biopsy,

A

triceps

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30
Q

behcets ASSOCIATED hla

A

hlab 51

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31
Q

GA subcutaneous commoner in which age group

A

children

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32
Q

krazy glue ACD

A

ethyl cyanoacrylate

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33
Q

tosylonamide formaldehyde causes

A

eyelid dermatitis

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34
Q

dermatomyosisits cytokine

A

TNFa,

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35
Q

anti Mi-2 significance

A

favorable prognosis

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36
Q

juvenile dermatomyosisits cytokine

A

↑ thrombospondin

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37
Q

Spindle cell lipoma location

A

posterior shoulder

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38
Q

A.A transport defect, AR, pellagra like, intermittent ataxia

A

hartnup disease

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39
Q

phyrnoderma

A

vitamin A deficiency~

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40
Q

diarrhea dementia photosensitive dermatitis

A

Pellagra-niacin def

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41
Q

INH, AZA, 5FU,

A

Pellagra-

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42
Q

• Malignant atrophic papulosis Degos disease

mortality

A

myocardial ischemia

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43
Q

large vessel –

A

takayasu arteritis,

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44
Q

Hydralazine HLA DR4, peicillamine cause

A

drug induced lupus-

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45
Q

14%, with slow acetylators (HLA-DR4)

more prone

A

Hydralazine induced lupus

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46
Q

What drug induces native SLE disease, with anti-dsDNA Ab’s

A

Penicillamine

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47
Q

Vitamin D deficiency- hair

A

alopecia,

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48
Q

Xanthoma disminatum to check gland?

A

pituitary gland, DI

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49
Q

Reiter- chronic deforming arthritis in %

A

20 %

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50
Q

schnitzlers syndrome aw

A

sensorimotor neuropathy

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51
Q

IgG lamda monoclonal gammotpathy dm strep infection

A

scleremyxedema-

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52
Q

Pulmonary Fibrosis raynauds ssystemic sclerosis - linear morphea,,- ,

A

bleomycin-

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53
Q

pitted keratolysis organism

A

Micrococcus sedentaris

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54
Q

Post transplant ctcl-renal stransplant

A

cyclosporine

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55
Q

ACE - sensitivity 60, specificity 80

A

Sarcoidosis

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56
Q

sneddon syndrome aw

A

venous thrombosis

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57
Q

debride cooling, effect dressing

A

Dhdrogel-

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58
Q

50s subunit

A

, emycin

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59
Q

inhibit RNA dependent protein synthesis bind 30s ribosomal

A

azithromycin

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60
Q

Long-term morbidity from kidney disease, which is predicted by the spread of purpura to
the upper trunk

A

HSP

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61
Q

DH and lymphoma risk

A

NHL

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62
Q

30% of patients with SLe

A

anti-U1RNP

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63
Q

Majority of patients with positive U1RNP have

A

SLE rather than MCTD

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64
Q

atypical beaded papule nasal rim

A

Lofgren syndrome

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65
Q

partial lipodystrophy mutation LMNA gene

A

dunnigan variant

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66
Q

shoulder blade rippled hyperpigmented

A

sipple syndrome

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67
Q

myotonic dystrophy aw

A

pilomatricomas

68
Q

MAGIC syndrome

A

relapsing polychondritis

69
Q

Erythema gyratum repens underlying

A

lung cancer

70
Q

ANA-negative sle → determined often on animal substrates, yet later found to be positive
on human cells, or if patient only makes antibodies to ?

A

ssdna (not detected by most tests)

71
Q

DMS hi-risk pulmonary dz,

A

anti Jo 1

72
Q

nevus achromicus congenital melanopenic ?extracutaneous assoc

A

no extracutaneous assoc

73
Q

safe anestehtic in mastocytosis

A

propofol

74
Q

Useful in testing ANA negative patients with clinical manifestations of sle or scle

A

ro la

75
Q

Neonatal lupus hematologic abn

A

thrombocytopenia,

76
Q

Light based acne therapy targets

A

Coproporphyrin 111

77
Q

Which Cytokine marker of psoriasis disease severity

A

IL22

78
Q

What cytokine in psoriasis stimulates Th1 cells

A

IL12

79
Q

What cytokine in psoriasis stimulates Th17 cells

A

IL23

80
Q

Onycholysis splinter hemorrhage and oil spots affects which part of nail

A

Nail bed

81
Q

Pitting leukonychia, onychodystrophy affects which part of nail

A

Nail matrix N.B onychodystrophy- bed and matrix

82
Q

Calcipotriene inactivated by

A

Salicylic acid

83
Q

effect of rifampin on OCP efficacy

A

reduces

84
Q

azelaic acid MOA acne

A

ihibit tyrosinase, PIPA

85
Q

psorriasis early onset HLA

A

B17

86
Q

psorriasis arthritis HLA

A

HLA B27

87
Q

PAPA syndrome mutations

A

AD, PSTPIP1, CD2BP1

88
Q

defective protein in FMF

A

pyrin

89
Q

which biologic CI in CHF, cause drug induced SLE

A

infliximab

90
Q

biologics which cause drug induced SLE

A

infliximab, etanercept

91
Q

cause of infantile acne

A

elevated LH levels

92
Q

Saroidosis lab abormality

A

Hypercalcemia

93
Q

Commonest systemic sclerosis systemi finding

A

Esophageal dysfunction

94
Q

ACE ihibitors cause angioedea via stimulation of

A

Bradykinin

95
Q 
Drug reaction with eosinophilia and
systemic symptoms (DRESS) syndrome is
a potentially life-threatening adverse
drug-induced reaction, with an
estimated mortality of
A

10%.

96
Q

most frequently reported causative agents of DRESS

syndrome

A

carbamazepine

97
Q

most frequently affected visceral organ of DRESS

syndrome

A

liver

98
Q

AGEP’s 5% mortality rate is most often

related to

A

secondary infection

99
Q

patch test-ing shouldbe performed when after DRESS

A

2 to 6 months after recoveryfrom the symptoms.

100
Q

recommended to per-form LTT when after the onset of DRESSsyndrome

A

5 to 8 weeks after the onset of DRESSsyndrome

101
Q

useful diagnostic imaging techniques

for assessing Cardiac Sarcoidosis

A

Positron emission tomographic and gadolinium-enhanced cardiac magnetic resonance imaging scans

102
Q

Eosinophils do reliably distinguish histologic findings of

drug exanthem from acute graft-versus-host disease

A

not

103
Q

In CGVHD, when is systemic therapy warranted?

A

Sclerotic skin involvement, particularly fascial disease, should prompt aggressive treatment before the development of
Skin contractures functional disability

104
Q

Calcification can be observed in ?panniculitis

A

Calcification can be observed in pancreatic pannicultis and lupus panniculitis

105
Q

Painful calcification on the finger has also been effectively treated
with

A

surgical debridement.

106
Q

Iodine use and iodine-containing diets (such asshellfish) have been reported to induce flares of

A

DH

107
Q

serologic tests that may confirm the diagnosis of dermatitis herpetiformis and be used to monitor disease activity

A

Tissue and epidermal transglutaminases

108
Q

DH likelihood of a family member having a similar condition?

A

18%

109
Q

? Raynaud phenomenon does not have nail-fold capillary changes, usually has an onset during the teenage years, and does not cause necrosis or gangrene of the digits

A

Primary

110
Q

Extracutaneous manifestations in morphea are ? rare

A

Not

111
Q

Morphea

The most common extracutanous manifestation is

A

arthralgia

112
Q

Morphea Central nervous systemfibrosis is most common in those children with

A

head and neck involvenent

113
Q

Children with head and neck morphea

should have regular

A

ophthalmologic examination monitor

for Asymptomaticinvolvement that may lead to irreversible damage

114
Q

The outcome

measure best suited for morphea is:

A 
Localized Scleroderma Cutaneous
Assessment Tool is a promising recently
validated skin scoring tool that allows
differentiation between activity and
damage, is sensitive to change, and
requires no additional equipment.
115
Q

two therapies for
morphea with the most
clinical data

A

Methotrexate in combination
with systemic steroids
and ultraviolet A1
light phototherapy

116
Q

morphea treatment Narrowband ultraviolet B light phototherapy
is as effective as low dose ultraviolet
A1 phototherapy

A

T

117
Q

Topical tacrolimus is an effective treatment

for active plaque morphea

A

t

118
Q

plaque morphea combination of calcipotriol in combination with betamethasone dipropionate is
supported by level

A

IIB evidence

119
Q

type of arthritis Morning stiffness(min)>60, better with activity

A

PsA, RA

120
Q 
Reactive arthritis (ReA) is distinguished from
psoriatic arthritis (PsA) by its
A
  • acute onset arthritis and enthesitis,

- additive involvement of new joints over days

121
Q

Which of the following imaging findings is unique to psoriatic arthritis

A

Osteopenia

122
Q

Osteophyte formation, joint space narrowing,

and the absence of erosions distinguish

A

OA from PsA on plain radiographic film

123
Q

CCP Ab Present in ?

A

RA

124
Q

Flame figures may be seen in which of thefollowing conditions?

a. Bullous pemphigoid
b. Eczema
c. Arthropod bites
d. Dermatophyte infections

A

All

125
Q

average age of onset of drug-induced SCLE is ?than that of idiopathic SCLE.

A

older (59.5 years)

126
Q

Associated disease with Pemphigoid gestationis

A

Graves disease is seen in about 10% of patients with PG

127
Q

calciphylaxis calcium phosphate product level

A

elevated calcium phosphate product (Ca 3 P) of[70 mg2/dL2 is associated with calciphylaxis, most patients with calciphylaxis have anormal product.

128
Q

Which nerve is responsible for sensory inner-vation of the most commonly affected site? In TTS?

A

b. Maxillary branch of the trigeminal nerve

129
Q

treatment of choice for EED is

A

dapsone

130
Q

Schnitzler syndrome best treatment

A

Anakinra, an IL-1 re-ceptor antagonist, appears to be a promising agent,

131
Q

Schnitzler syndrome Cx

A

Waldenstro¨m macroglobulinemia

132
Q

Vanco RMS cause

A

Degranulation of mast cells independently ofimmunoglobulin E or complemen

133
Q

Type 6 PRP

A

HIV associated, follicular spines, Hidradenitis suppurativa, acne conglobata

134
Q

PRP subtype familial cases associated with ichthyosiform scaling, sclerodermatous changes of the hands and feet.

A

Type V,atypical juvenile PRP,

135
Q

most common juvenile variant, PRP.

A

Juvenile focal—or type IV—PRP representsthe most common juvenile variant, and the secondmost common variant overall, accounting for ap-proximately 25% of all cases.

136
Q

mangos (Mangifera indica) belong to the ?-containing plant family Anacardiaceae, and sensitized patients can develop a contact dermatitis similar to that of ?.

A

Urushiol—Correct. Like poison ivy, mangos (Mangifera indica) belong to the urushiol-containing plant family Anacardiaceae, and sensitized patients can develop a contact dermatitis similar to that of poison ivy contact dermatitis.The resorcinol in mango cross-reacts in patch tests with the catechols of poison ivy.

137
Q

Japanese lacquer tree, cashew nut tree, ginkgo fruit pulp, the marking nut tree of India, and the Brazilian pepper tree. Mango, poison ivy

A

sources of urushiol

138
Q

valuable therapeutic option for the treatment of refractory cutaneous cGvHD;

A

ECP

139
Q

Treatment for cutaneous sarcoidosis first-line therapy for localized scar sarcoidosis.

A

Topical or intralesional corticosteroid

140
Q

production of colored sweat that contains water-soluble pigments. The consumption of drugs, such as quinine, has been reported to be causative.

A

Eccrine chromhidrosis—

141
Q

What steroid-sparing agent is often used with oral corticosteroids to treat pemphigus vegetans?

A

Acitretin—Correct. The use of acitretin and steroids has been reported to be effective in the treatment of large verrucous lesions of PV.

142
Q

treatments is most appropriate for this persistent, pruritic rash?grovers

A

Pramoxine lotion twice daily and as needed for pruritus

143
Q

Id reaction cytokine

A

interleukin-1

144
Q

is a sudden,generalized eczematous eruption which occurs dis-tant fromthe primary condition. It is commonly seenin stasis dermatitis, contact dermatitis, and infectionsfrom bacteria and dermatophytes, pediculosis, molluscum contagiosum, my-cobacterium infection, and radiation therapy.

A

Id reaction, or autoeczematization,

145
Q

Renbok phenomenon, or inverse Koebner phenomenon,

A

was first described in 1991 by Happle in an individual afflicted with two skin diseases (alopecia areata and psoriasis). It refers to normal hair growth in psoriatic plaques surrounded by hair loss caused by alopecia areata.

146
Q

exhibit apple jelly color on diascopy,

A

Lupus vulgaris, sarcoidosis

147
Q

?xanthomas seen in familial hypercholesterolemia.

A

familial hypercholesterolemia.

148
Q

? xanthomas can occur with hypertriglyceridemia.

A

hypertriglyceridemia.

TC, ET,

149
Q

? xanthomas can be seen with dysbetalipoproteinemia.

A

Palmar xanthomas can be seen with dysbetalipoproteinemia.

Terms &Conditions, Extra Terrestrial, Play Bad

150
Q

?xanthomas, which are protuberant nodules over the knees and elbows, also occur in familial hypercholesterolemia

A

Tuberous xanthomas, which are protuberant nodules over the knees and elbows, also occur in familial hypercholesterolemia but were not present in this patient.
Mnemonic
145 Extra- Terrestials ( eruptive, hypertriglyceridemia)
Play Bad ( palmar, dysBetalipoproteimemia) so u better agree to
Terms & Conditions i.e. Bad ( tuberous,tendinous hypercholesterolemia, also dysBetaliproteinemia ),

151
Q

following has (have) been associated withsyringomas

A

a. Marfan syndrome
b. Down’s syndrome
c. atrophoderma vermiculata
d. EhlerseDanlos syndrome

152
Q

Secondary cold urticaria has in some patients been associated with

A

hepatitis B or C infection, lymphoproliferativedisease, or infectious mononucleosis.

153
Q

PLEVA, vs PLC histo

A

PLEVA, apoptotic and necrotic keratinocytes, neutrophils, and erythrocytes epidermotropic infiltrate of CD8+ T lymphocytes. Parakeratosis vs PLC CD4+

154
Q

Antibodies associated with MCTD

A

U1RNP, hnRNP2

155
Q

digital skin color changes with Raynaud’sphenomenon naturally progress in which of thefollowing orders?

A

d. white then blue then red

156
Q

Raynauds ismost often seen in association with

A

systemic sclero-sis.

157
Q

Pellagra caused by

A

niacin , comes fromsynthesis fromtheamino acid tryptophan. This process requires vita-mins B2 and B6 (riboflavin and pyridoxine

158
Q

a. malabsorptive disorders
b. chronic alcoholism
d. Hartnup’s disease
e. carcinoid syndrome

A

Pellagrous

159
Q

trigeminal trophic syndrome best treatment

A

The best treatment is use of an occlu-sive dressing or prosthesis, which prevents furthermanipulation.

160
Q

Axillary parakeratosis defect

A

in processing of profilaggrin to filaggrin

161
Q

Sarcoidosis is associated

with

A

CD4+ Th1 T-helper cells

162
Q

Sarcoidosis has been associated with the fol-lowing
lymphoproliferative
disorders

A

chronic myelogenous leukemia

b. hairy cell leukemia
d. Hodgkin’s lymphoma
e. non-Hodgkin’s lymphoma

163
Q

Sarcoidosis has been associated with the fol-lowing solid tumors

A

a. testicular cancer
c. melanoma
d. lung cancer
e. carcinoid tumors

164
Q

Sarcoidosis is associated with HLA-

A

Sarcoidosis is associated with

a. HLA-1
b. HLA-B8
c. HLA-DR3

165
Q

Sarcoidosis has been associated the followingautoimmune disorders

A

a. vitiligo
c. autoimmune thyroiditis
d. Sjogren’s syndrome
e. systemic lupus erythematosus

166
Q

Id reaction cytokines

A

interleukins 1 and 6 and tumor necrosis factor a

AAD ETAS (12 decks)

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