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AAD ETAS > basic > Flashcards

basic Flashcards

1
Q

which keratin de novo in stratum basale

A

k5/14

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2
Q

Which keratins are on acidic chr 17?

A

K10-20, 9-28

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3
Q

Which layer of skin has desmosomal connections calcium dependent

A

stratum spinosum spines

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4
Q

Il23 is released from?

A

keratinocytes

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5
Q

IL1,6,8,TNF-a, is released from?

A

keratinocytes

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6
Q

Mucocutaneous receptors found on glans penis, clitoris, labia minora, peri-anal area, and vermillion border of the lips

A

krause

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7
Q

mononuclear phagocytic cells staining

A

CD6

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8
Q

% dry wt elastin

A

4 %

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9
Q

melanocyte:keratinocyte

A

1:36

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10
Q

keratinized epidermis

A

24 w

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11
Q

type 1 ? type 3 collagen

A

>

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12
Q

What fibres have less elastin and more fibrillin; run parallel in thin bands within the
reticular dermis

A

elaunin fibres

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13
Q

Elastic fibers: ?% elastin, wrapped by fibrillin microfibrils (mutated in Marfan’s)

A

90%elastin

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14
Q

typical amino acids found in elastic fibers, and crosslinkfibrillin requires lysyl oxidase (copper-dependent process)

A

desmosine isoesmosine

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15
Q

contain no elastin; run perpendicular from DEJ within superficial papillary dermis

A

Oxytalan fibers:

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16
Q

laminin 5 is found in which part of BMZ?

A

lamina densa,

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17
Q

amnion contains what type collagen ?

A

type 7 collagen ,

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18
Q

granulation tissue type collagen?

A

colagen 3,

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19
Q

proline hydroxyproline constituents of

A

collagen

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20
Q

function odland bodies ?

A

SC h20 loss barrier

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21
Q

basal–SC transition time

A

14d

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22
Q

decreased lamellar granules occurs in ?

A

flegels ,

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23
Q

absent lamellar granules

A

harlequin icthyosis

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24
Q

warts renal transplant

A

k13

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25
Q

abrupt cessation mitotic activity rapidly dividing hair matrix

A

anagen effluvium

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26
Q

EB +MA ,

A

Plectin,

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27
Q

JEB +PA

A

integrin,

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28
Q

Ocular CP-JEB PA

A

B4 of a6b4 integrin

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29
Q

EBS weber cockayne

A

k5

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30
Q

mucosal melanoma

A

KIT

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31
Q

In upper spinous layer and throughout the stratum granulosum

– 75% of CE’s mass (major protein component of CE)

A

loricrin

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32
Q

more dispersed melanosomes

A

darker skin

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33
Q

wound healing , granulation tissue

A

fibronectin

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34
Q

macrophage

A

wound healing,

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35
Q

BM collagen

A

collagen 4,

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36
Q

,melanosomes after

A

golgi apparatus

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37
Q

• nail keratin

A

k6b/17,

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38
Q

cutis laxa marfans anetoderma, pXE

A

elastic fibres fragmentation-

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39
Q

kf insert into

A

desmosomes,

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40
Q

larger singly dispersed melanosomesbut same melanocyte no,

A

dark skin

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41
Q

Tyrosine->DOPA

A

> DOPAquinone,

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42
Q

WB body is a

A

protein

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43
Q

BP 230-desmoplakin belongs to what family

A

plakin

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44
Q

melanocyte genesis occurs when

A

3rd month

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45
Q

k6-16 is upregulated in

A

psoriaiss

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46
Q

human sebum is differntiated from other lipid by

A

wax esters

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47
Q

mononuclear phagocytes express

A

CD11c, CD6; CR4

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48
Q

PPARI3 is expressed in

A

LPP

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49
Q

CD 34 + stainin

A

mast cell

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50
Q

integrins intermediate filaments insert into

A

+ECM

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51
Q

guinea pig esophagus,

A

folgo selvagem

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52
Q

black fly

A

folgo selvagem

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53
Q

no value in neonatal LE,

A

DIF

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54
Q

zeis

A

specialised sebaceous (eyelash

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55
Q

montgomery tubercle

A

areolar sebaceous)

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56
Q

meibomian

A

eyeld sebaceous

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57
Q

plakoglobin family

A

armadillo

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58
Q

postganglionic

A

acetylcholine

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59
Q

CPA cytarabine cipro cephalexin common point

A

eccrine []

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60
Q

apocrine not present in

A

palms

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61
Q

sebaceous ca stain

A

EMA

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62
Q

NOT under neural ctrl,

A

sebaceous

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63
Q

abn collagen xlink

A

homocystinuria

64
Q

hair follicle direction growth

A

cephalad to caudal

65
Q

urocanic acid

A

UVA filter

66
Q

cs receptor location

A

cytoplasm

67
Q

PNP /senear usher DIF

A

BMZ intercellular

68
Q

LP DIF

A

granular DEJ,

69
Q

NC16a BP180, ,

A

BP

70
Q

SCLE DIF

A

granular cytoplasm nucleus

71
Q

primodrial hair embrogeneisis

A

9 w,

72
Q

periderm

A

vernix caseosa

73
Q

•DHT MSH prolactin, ACTH, MMP zn,

A

hair follicle

74
Q

Inside to outside

A

Cuticle - IRS - Huxley-Henle - ORS - glassy/vitreous

75
Q

Three compartments, stains red because citrulline

A

Inner root sheath: Three compartments, stains red because citrulline

  1. ) Henle’s layer - keratinizes first
  2. ) Huxley’s layer
  3. ) Cuticle
76
Q

critical line auber-

A

widest diameter,

77
Q

first area where change from vellus to terminal hair occurs in puberty

A

pubic region. Axillary hair 2 years later

78
Q

change of content of Odland bodies

A

As they move up in granular cell layer content changes neutral sugars lipids, and/or proteins, hydrolytic enzymes, and free sterols phospholipids diminish, neutral lipids and sphingolipids increase.
Cholesterol sulfate increases spinous to the granular layer b decreases stratum corneum

79
Q

Osteoclastic

A

giant cells with eosinophilic cytoplasm

80
Q

___separates the trilaminar plasma membrane from the lamina densa

A

lamina lucida

81
Q

mice, production of EGF may be affected by

A

estrogen and testosterone

82
Q

Receptors for EGF may also occur in mitotically inactive cells such as

A

sweat ducts

83
Q

Receptors for EGF are mainly found in

A

basal cell layer

84
Q

Langerhans cell density decreases in

A

UV exposure, intrinsic aging, palms, soles, and anogenital region

85
Q

collagen lamina densa.

A

Type 4

86
Q

Langerhans cell density higher

A

face, neck, trunk and limbs 600 – 1000/sq mm

87
Q

Anchoring filaments, rich in

A

laminin 5

88
Q

lamina lucida thickness

A

is 30 to 60 nm

89
Q

western blot identifies

A

Protein

90
Q

northern blot identifies

A

RNA

91
Q

southern blot identifies

A

DNA.

92
Q

markers for hyperproliferative keratinocytes. They are found in skin disease such as psoriasis, warts, actinic keratoses, and SCC’s.

A

K16 and K6

93
Q

k2e/10

A

upper spinous and granular cell layers,

94
Q

k 1/9 in

A

palmoplantar suprabasalar keratinocytes,

95
Q

k4/13 expressed in

A

mucosal epithelium.

96
Q

K6a/16 is expressed in

A

outer root sheath and in hyperproliferative keratinocytes

97
Q

keratins expressed in the nail bed.

A

Keratins 6b & 17

98
Q

Plectin is a member of the

A

plakin family

99
Q

may be found in association with hair follicles or in some areas of modified skin such as the nipple/areola, labia minora, prepuce, vermilion border, and eyelids.

A

Sebaceous glands

100
Q

CD6 and CD11c are expressed on all

A

mononuclear phagocytic cells in the dermis.

101
Q

involucrin levels are increased in

A

In psoriasis,_

102
Q

In psoriasis,_filaggrin and loricrin levels are

A

diminished.

103
Q

Oxytalan fibers run____ from the DEJ within the superficial papillary dermis.

A

PERPENDICULAR

104
Q

Elaunin fibers run __ in thin bands within the reticular dermis.

A

parallell

105
Q

K16 and K6 are found in the

A

palms and soles.

106
Q

K5 and K14 are found in

A

the basal layer.

107
Q

K3 and K12 are found in the

A

suprabasilar cells of the cornea

108
Q

cystathione synthase mutation causes what?

A

Homocystinuria

109
Q

Lysyl hydroxylase is deficient in which type of EDS

A

Kyphoscoliosis type of EDS

110
Q

Tenascin X is involved in what type of EDS?

A

Classical type EDS

111
Q

dermatosparaxis type EDS has recessive mutations in the

A

type I collagen N-peptidase gene.

112
Q

When do LC merkel cells melanocytes appear in embrology?

A

8-12 weeks

113
Q

When does nail plate completely cover nail bed in emryogenesis?

A

15-20 weeks , second trimester

114
Q

When does fetal basement membrane develop?

A

7 wk

115
Q

What happens at 12 weeks embrogenesis?

A
  1. DEJ form
  2. Nail bed keratinizes, proximal nail fold formation
  3. Collagen 3
116
Q

Additional layerin plamoplantar epidermis known as ?

A

Stratum lucidum

117
Q

When does mature epidermis become complete with interfollicular keratinization?

A

22-24 weeks

118
Q

Which keratin on basic chr 12?

A

Type 2 k1-8 k71-80

119
Q

Ornithine decarboxylase in expressed in which layer ?

A

Stratum basale

120
Q

What protein defect causes
Vohwinkel
PPK with deafness
KID syndrome

A

Connexin 26

121
Q

What protein defect causes

Erythrokeratoderma variabilis?

A

Connexin 30.3/31

122
Q

Connexin 30 ( gap junction protein) defect causes

A

Hidrotic ectodermal dysplasia

123
Q

What condition with increased lamellar granules but structurally abnormal?

A

CIE

124
Q

What conditions with decreased lamellar granules ?

A

Flegel, harlequin icthyosis

125
Q

When does mature epidermis complete with interfollicular keratinization

A

22-24 wk

126
Q

What causes naxos syndrome

A

Plakoglobin( desmosome)

127
Q

What is the only common protein between adherens juction and desmosome

A

Plakoglobin

128
Q

Defect in which protein causes carvajal syndrome

A

Dsmoplakin

129
Q

Plakophilin defect causes

A

Ectodermal dysplasia with skin fragility

130
Q

What structure makes up lamina lucida?

A

Anchoring filaments

131
Q

What structure makes up lamina densa?

A

Anxhoring plaque

132
Q

What structure makes up sublamina densa?

A

Anchoring fibril

133
Q

What structure is made up of type 4 collagen, laminins, heparan sulfate?

A

Anchoring plques(lamina densa)

134
Q

What structure is composed of type 7 collagen, fibrilin, type 1,3,4 collagen?

A

Anchoring fibril

135
Q

Which layer of BMZ Made up of hemidesmosome

A

Basal keratinocyte,plasma membrane( attachment to ECM)

136
Q

The hemidesmosomes are made up of ?

A

BPAG1, BPAG2, a6b4 integrin, plectin

137
Q

BPAG1 is a member of

A

Plakin

138
Q

BPAG2 is a member of

A

Collagen 17

139
Q

Domain targeted by BP, labd ?

A

NC16A extracelular domain

140
Q

Domain targeted by CP?

A

Carboxy terminal extracellular

141
Q

CP target Ag?

A

BPag2
laminin 5
a6b4 integrin

142
Q

Superantigens are ?Disease occurs when ?

A

Superantigens are polypeptides that activate large numbers of T cells
abnormally. Disease occurs when large amounts of proinflammatory cytokinesare produced.

143
Q

Specific superantigens activate T cells bearing

A

specific amino acid sequences on the VB region of the T-cell receptor.

144
Q

Toxic shock syndrome is a rapidly progressive, serious systemic illness
caused by superantigens produced by

A

superantigens produced by Saureus and group A Streptococcus.

145
Q

Streptococcal TSS is usually associated with

A

severe necrotizing soft tissue infection.

146
Q

Psoriasis presence of staphylococcal colonization and staphylococcal SAgs is associated

A

with more severe disease

147
Q

Clindamycin why should it be included in the antibiotic regimen for Necrotizing soft tissue infection

A

Clindamycin has been shown to inhibit toxin production by both S aureus and GAS

148
Q

Complement involved in both innate and adaptive

A

T

149
Q

Innate immunity can bind to self antigens. T?

A

F . Only to non self

150
Q

IL2, 4, 5, IFNy, TGFb part of cytokines for whichi immunity?

A

Adaptive

151
Q

Cytokines of innate immunity are.

A

Il 1,10, 12, IFN a/b

152
Q

What are cellular component of innate immunity

A

Macrophage NK cell mast cell eosinophil

153
Q

Which pathway results in NFKb activation

A

TLR pathway

154
Q

Which protein complex controls transcription of DNA

A

NFKB

155
Q

Th2 cell mileiu

A

IL4,5,6,10

156
Q

IL 2, 12, IFNy, TNF a belong to which T cell subtype ?

A

Th1

AAD ETAS (12 decks)

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